A5024296406- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Renal cell carcinoma treatment
- Prostate Cancer Diagnosis and Treatment
- Ureteral procedures and complications
- Urinary Bladder and Prostate Research
- Epigenetics and DNA Methylation
- Pelvic floor disorders treatments
- Prostate Cancer Treatment and Research
- Frailty in Older Adults
- Kidney Stones and Urolithiasis Treatments
- Esophageal Cancer Research and Treatment
- Sexual function and dysfunction studies
- Nutrition and Health in Aging
- Ferroptosis and cancer prognosis
- Pediatric Urology and Nephrology Studies
- Cancer Genomics and Diagnostics
- Surgical Simulation and Training
- Genital Health and Disease
- Multiple and Secondary Primary Cancers
- Urinary Tract Infections Management
- Health Systems, Economic Evaluations, Quality of Life
- Urologic and reproductive health conditions
- Renal and related cancers
Essen University Hospital
2025
BG Klinikum Duisburg
2024
Helios Klinikum Krefeld
2021-2023
University of Duisburg-Essen
2021-2023
Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde
2023
Jena University Hospital
2013-2021
St. Josef Krankenhaus
2021
Malteser-Krankenhaus
2015-2020
University of Tübingen
2003-2019
Benha University
2019
Abstract The molecular landscape in non-muscle-invasive bladder cancer (NMIBC) is characterized by large biological heterogeneity with variable clinical outcomes. Here, we perform an integrative multi-omics analysis of patients diagnosed NMIBC ( n = 834). Transcriptomic identifies four classes (1, 2a, 2b and 3) reflecting tumor biology disease aggressiveness. Both transcriptome-based subtyping the level chromosomal instability provide independent prognostic value beyond established...
Purpose: The European Association of Urology (EAU) guidelines for non-muscle-invasive bladder cancer (NMIBC) recommend risk stratification based on clinicopathologic parameters. Our aim was to investigate the added value biomarkers improve NMIBC.Experimental Design: We prospectively included 1,239 patients in follow-up NMIBC six countries. Fresh-frozen tumor samples were analyzed GATA2, TBX2, TBX3, and ZIC4 methylation FGFR3, TERT, PIK3CA, RAS mutation status. Cox regression analyses...
Abstract Introduction and Objectives The dosage of the antimuscarinic drugs: Tolterodine ER or Trospium was increased to a higher‐than‐recommended in patients where manufacturer's recommended had failed. All were suffering from neurogenic detrusor overactivity incontinence. Tolerability success evaluated present study. Materials Methods Twenty‐one with evaluated: 17 spinal cord injury, 3 multiple sclerosis, 1 meningomyelocele. catheterized themselves catheterized. If continued medication...
To prospectively compare the AirSeal® System valve-less Trocar with a standard Versaport™ Plus V2 as assistant insufflating port in transperitoneal and extraperitoneal robotic-assisted radical prostatectomy (t-RARP/e-RARP).Two consecutive cohorts of patients undergoing RARP using either 12 mm AirSeal (n=19 [14 t-RARP/5 e-RARP]) or Versaport (n=17 [11 t-RARP/6 were evaluated. Age, body mass index, tumor characteristics, surgical approach similar both cohorts. Besides relevant clinical data,...
Background and Purpose: In recent years, mini-percutaneous nephrolitholapaxy (mini-PCNL) has gained popularity because of its reduced invasiveness. To improve clinical outcomes further, research is ongoing in selected centers. Important areas interest include extravasation into the retroperitoneal space, acute absorption syndrome, septicemia. The aim this experimental study was to test a new 18F nephroscope sheath specially designed decrease intrapelvic pressure during mini-PCNL whatever...
Objective. The aim of the study was to investigate whether combinations urine-based tumour markers including urinary cytology (Cytology or Cyt) increase sensitivity in detection bladder cancer recurrence. Material and methods. Urinary cytology, NMP22, UroVysion (FISH) ImmunoCyt™ (uCyt+) were determined 221 patients during follow-up non-muscle-invasive transitional cell carcinoma (NMI TCC) before cystoscopy (n = 49) with suspicion TCC recurrence transurethral resection 173). For all alone as...
The technique for radical cystectomy in women is described, with special consideration given to the pelvic anatomy, and urethra- nerve-sparing approach female patients. Advances understanding following detailed animal, cadaveric clinical studies, merged give a better intraoperative identification of sphincteric apparatus neurovascular structures. Respecting oncological premises, patients can be done technique. In rare cases entire inner genitalia, including anterior vaginal wall, preserved,...
The aim of this article is to analyse the long-term results different surgical techniques for correction penile deviations in Peyronie's disease. Patients who underwent surgery a deviation disease between 1997 and 2007 were included into study. Cases retrospectively analysed by chart review. current situation was evaluated 16-item standardized questionnaire addressing straightness, sensation, length, sexual function satisfaction. Ninety patients contacted with return rate 75 (83%) evaluable...
The Geriatric 8 (G8) score, a widely used screening tool to assess frailty in older adults with cancer,1van Walree IC Scheepers E van Huis-Tanja L et al.A systematic review on the association of G8 geriatric assessment, prognosis and course treatment patients cancer.J Geriatr Oncol. 2019; 10: 847-858Summary Full Text PDF PubMed Google Scholar is recommended by several guidelines.2Droz JP Albrand G Gillessen S al.Management prostate cancer elderly patients: recommendations task force...
Robotic-assisted radical prostatectomy (RARP) is feasible using either an extraperitoneal (EP) or a transperitoneal (TP) approach. This study reports on the experience of single hospital both techniques.From July 2009 to March 2011, 170 patients underwent RARP. EP was chosen in 103 and TP 67. preferred cases previous mesh hernia repair if extended lymph-node dissection (LND) considered necessary. Otherwise, performed; it obesity (body mass index (BMI) > 30 kg/m(2)) intra-abdominal...