Manuel Ruh
A5067315228- CAR-T cell therapy research
- Cancer Research and Treatments
- Biomedical Ethics and Regulation
- Virus-based gene therapy research
- Immunotherapy and Immune Responses
- Mesenchymal stem cell research
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Neonatal Respiratory Health Research
- MicroRNA in disease regulation
- Nutrition, Genetics, and Disease
- Tissue Engineering and Regenerative Medicine
- Peptidase Inhibition and Analysis
- Histone Deacetylase Inhibitors Research
- Metabolomics and Mass Spectrometry Studies
- Bioinformatics and Genomic Networks
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
Immatics Biotechnologies (Germany)
2023
Friedrich-Alexander-Universität Erlangen-Nürnberg
2015-2021
University Children's Hospital Tübingen
2015
University of Tübingen
2010-2015
Research Article14 April 2015Open Access Source Data ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat Simone Meidhof Department of General and Visceral Surgery, University Freiburg Medical Center, Freiburg, Germany Spemann Graduate School Biology Medicine (SGBM), Albert Ludwigs Faculty Biology, Search for more papers this author Brabletz Experimental I, Nikolaus-Fiebiger-Center Molecular Medicine, FAU Erlangen-Nürnberg, Erlangen, Waltraut...
Mesenchymal stromal cells (MSC) can be isolated from different tissues. They are capable of differentiating in vitro, for example, to osteoblasts, chondrocytes, or adipocytes. In contrast CD34 hematopoietic stem cells, a distinct MSC-defining antibody is not available. Further, lineage-defining antigens such as CD3 CD20 known. contrast, MSC-derived lineage-associated cell surface markers far being established. We therefore investigated expression on human term placenta-derived MSC (pMSC)...
Mesenchymal stromal cells (MSCs) are multipotent that can be differentiated in vitro into a variety of cell types, including adipocytes or osteoblasts. Our recent studies indicated high expression CD146 on MSCs from bone marrow correlates with their robust osteogenic differentiation potential. We therefore investigated if the placenta similar The were isolated specifically endometrial and fetal parts human term expanded separate cultures compared as controls. surface antigens was by flow...
Osteosarcoma is an often-fatal mesenchyme-derived malignancy in children and young adults. Overexpression of EMT-transcription factors (EMT-TFs) has been associated with poor clinical outcome. Here, we demonstrated that the EMT-TF ZEB1 able to block osteoblastic differentiation normal bone development as well osteosarcoma cells. Consequently, overexpression characterizes poorly differentiated, highly metastatic subgroups its depletion induces frequently silencing imprinted DLK-DIO3 locus,...
Abstract Mesenchymal stromal cells (MSCs) do not express a unique definite epitope or marker gene. As such, minimal criteria were recently established for defining multipotent MSC. These include expression of CD73, CD90, CD105, and lack hematopoietic expression. However, we detected binding CD14 antibody on bone marrow‐ placenta‐derived MSC investigated the staining antibodies these in more detail. The isolated from human marrow placenta tissue, expanded, characterized by quantitative...
Abstract IMA101 is an actively personalized, multi-targeted adoptive cell therapy (ACT), whereby autologous T cells are directed against multiple novel defined peptide-HLA (pHLA) cancer targets. HLA-A*02:01-positive patients with relapsed/refractory solid tumors expressing ≥1 of 8 predefined targets underwent leukapheresis. Endogenous specific for up to 4 were primed and expanded in vitro. Patients received lymphodepletion (fludarabine, cyclophosphamide), followed by T-cell infusion low-dose...
Background Platforms like tranSMART assist researchers in analyzing clinical and corresponding omics data. Usability is an important, yet often overlooked, factor affecting the adoption meaningful use. Analyses on specific needs of translational considerations about application such platforms for education are rare. Objectives The aim this study was to test whether can be used how well medical students professional handle it; identify which kind researchers—in terms skills, experienced...
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