Sabrina Kuttruff-Coqui

ORCID: 0009-0009-2998-1598
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About
Contact & Profiles
Research Areas
  • CAR-T cell therapy research
  • Cancer Research and Treatments
  • Biomedical Ethics and Regulation
  • Immunotherapy and Immune Responses
  • Virus-based gene therapy research
  • Nanoplatforms for cancer theranostics
  • Monoclonal and Polyclonal Antibodies Research
  • Cancer Immunotherapy and Biomarkers

Immatics Biotechnologies (Germany)
2016-2023

Abstract IMA101 is an actively personalized, multi-targeted adoptive cell therapy (ACT), whereby autologous T cells are directed against multiple novel defined peptide-HLA (pHLA) cancer targets. HLA-A*02:01-positive patients with relapsed/refractory solid tumors expressing ≥1 of 8 predefined targets underwent leukapheresis. Endogenous specific for up to 4 were primed and expanded in vitro. Patients received lymphodepletion (fludarabine, cyclophosphamide), followed by T-cell infusion low-dose...

10.1158/2326-6066.cir-22-0444 article EN Cancer Immunology Research 2023-05-12
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