A5077731612- Genetic Associations and Epidemiology
- Protein Degradation and Inhibitors
- Genomics and Chromatin Dynamics
- Insect Resistance and Genetics
- Bioinformatics and Genomic Networks
- Alzheimer's disease research and treatments
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Genetic Mapping and Diversity in Plants and Animals
- Receptor Mechanisms and Signaling
- Genomic variations and chromosomal abnormalities
- Genomics and Rare Diseases
- Liver Disease Diagnosis and Treatment
- Gene expression and cancer classification
- Memory and Neural Mechanisms
- Nutrition, Genetics, and Disease
- Protein Structure and Dynamics
- Vestibular and auditory disorders
- Nuclear Receptors and Signaling
- Genetics and Neurodevelopmental Disorders
- Tryptophan and brain disorders
- Ion channel regulation and function
- RNA and protein synthesis mechanisms
- Neural dynamics and brain function
- Parkinson's Disease Mechanisms and Treatments
University of Oslo
2015-2025
Oslo University Hospital
2015-2019
Rogers (United States)
2016
Molecular Oncology (United States)
2016
European Bioinformatics Institute
2016
Wellcome Trust
2016
Institute of Cancer Research
2016
University of California, San Diego
2015
Kavli Institute for Systems Neuroscience
2013
Background Identifying individuals at risk for developing Alzheimer disease (AD) is of utmost importance. Although genetic studies have identified AD-associated SNPs in APOE and other genes, information has not been integrated into an epidemiological framework prediction. Methods findings Using genotype data from 17,008 AD cases 37,154 controls the International Genomics Alzheimer's Project (IGAP Stage 1), we (at p < 10−5). We then these a Cox proportional hazard model using subset 6,409...
Recent genome-wide association studies (GWAS) and pathway analyses supported long-standing observations of an between immune-mediated diseases Parkinson disease (PD). The post-GWAS era provides opportunity for cross-phenotype different complex phenotypes.To test the hypothesis that there are common genetic risk variants conveying both PD autoimmune (ie, pleiotropy) to identify new shared their pathways by applying a novel statistical framework in approach.Using conjunction false discovery...
Late-onset Alzheimer disease (AD), the most common form of dementia, places a large burden on families and society. Although epidemiological clinical evidence suggests relationship between inflammation AD, their is not well understood could have implications for treatment prevention strategies.To determine whether subset genes involved with increased risk are also associated AD.In genetic epidemiology study conducted in July 2015, we systematically investigated overlap AD (International...
Schizophrenia is associated with widespread cognitive impairments. Although deficits are one of the factors most strongly functional outcome in schizophrenia, current treatment strategies largely fail to ameliorate these To develop more efficient patients a better understanding pathogenesis needed. Accumulating evidence indicates that genetic risk schizophrenia may contribute dysfunction.To identify genomic regions jointly influencing and domains reaction time verbal-numerical reasoning, as...
Schizophrenia (SCZ) is associated with differences in subcortical brain volumes and intracranial volume (ICV). However, little known about the underlying etiology of these alterations. Here, we explored whether structure SCZ share genetic risk factors. Using conditional false discovery rate (FDR) analysis, integrated genome-wide association study (GWAS) data on (n = 82315) GWAS 7 ICV 11840). By conditioning FDR overlapping associations, this statistical approach increases power to discover...
Schizophrenia is associated with differences in personality traits, and recent studies suggest that traits schizophrenia share a genetic basis. Here we aimed to identify specific loci shared between the Big Five using Bayesian statistical framework. Using summary statistics from genome-wide association (GWAS) on 23andMe cohort (n = 59,225) Psychiatric Genomics Consortium 82,315), evaluated overlap common variants. The neuroticism, extraversion, openness, agreeableness conscientiousness were...
There is evidence for genetic overlap between cognitive abilities and schizophrenia (SCZ), genome-wide association studies (GWAS) demonstrate that both SCZ general have a strong polygenic component with many single-nucleotide polymorphisms (SNPs) each small effect. Here we investigated the shared architecture educational attainment, which regarded as "proxy phenotype" abilities, but may also reflect other traits. We applied conditional false discovery rate (condFDR) method to GWAS of (n = 82...
Coronary artery disease (CAD) is a critical determinant of morbidity and mortality. Previous studies have identified several cardiovascular risk factors, which may partly arise from shared genetic basis with CAD, thus be useful for discovery CAD genes.We aimed to improve genes inform the pathogenic relationship between factors using polygenic signal-informed statistical framework.Using genome-wide association summary statistics pleiotropy-informed conditional conjunctional false rate...
Abstract Dementia with Lewy Bodies (DLB) is a common neurodegenerative disorder poor prognosis and mainly unknown pathophysiology. Heritability estimates exceed 30% but few genetic risk variants have been identified. Here we investigated associated DLB in large European multisite sample. We performed genome wide association study Norwegian cohorts of 720 cases 6490 controls included 19 top-associated single-nucleotide polymorphisms an additional cohort 108 75545 from Iceland. Overall the 828...
Migraine is a recurrent pain condition traditionally viewed as neurovascular disorder, but little known of its vascular basis. In epidemiological studies migraine associated with an increased risk cardiovascular disease, including coronary artery disease (CAD), suggesting shared pathogenic mechanisms. This study aimed to determine the genetic overlap between and CAD, identify loci, utilizing conditional false discovery rate approach data from two large-scale genome-wide association (GWAS)...
Background: Alzheimer's disease (AD) and bipolar disorder (BIP) are complex traits influenced by numerous common genetic variants, most of which remain to be detected. Clinical epidemiological evidence suggest that AD BIP related. However, it is not established if this relation origin. Here, we applied statistical methods based on the conditional false discovery rate (FDR) framework detect overlap between utilized increase power identify variants associated with either or both traits....
Genome-wide Association Studies (GWAS) result in millions of summary statistics ("z-scores") for single nucleotide polymorphism (SNP) associations with phenotypes. These rich datasets afford deep insights into the nature and extent genetic contributions to complex phenotypes such as psychiatric disorders, which are understood have substantial components that arise from very large numbers SNPs. The complexity datasets, however, poses a significant challenge maximizing their utility. This is...
Abstract Late onset Alzheimer’s disease (AD) is the most common form of dementia with more than 35 million people affected worldwide, and no curative treatment available. AD highly heritable recent genome-wide meta-analyses have identified over 20 genomic loci associated AD, yet only explaining a small proportion genetic variance indicating that undiscovered exist. Here, we performed largest association study clinically diagnosed AD-by-proxy (71,880 cases, 383,378 controls). status based on...
Neurons that signal the angular velocity of head movements (AHV cells) are important for processing visual and spatial information. However, it has been challenging to isolate sensory modality drives them map their cortical distribution. To address this, we develop a method enables rotating awake, head-fixed mice under two-photon microscope in environment. Starting layer 2/3 retrosplenial cortex, key area vision navigation, find 10% neurons report (AHV). Their tuning properties depend on...
Highlights•Time cells are found in the retrosplenial cortex (RSC), a region linked to episodic memory•RSC time encode elapsed and odor identity conjunctively•The fraction of RSC is similar that hippocampus•Time-encoding far less common neocortical regions adjacent RSCSummaryEpisodic memory requires remembering temporal sequence events, process attributed hippocampal "time cells." However, distributed nature brain areas supporting suggests representations may extend beyond hippocampus. To...
Most of the genetic architecture schizophrenia (SCZ) has not yet been identified. Here, we apply a novel statistical algorithm called Covariate-Modulated Mixture Modeling (CM3), which incorporates auxiliary information (heterozygosity, total linkage disequilibrium, genomic annotations, pleiotropy) for each single nucleotide polymorphism (SNP) to enable more accurate estimation replication probabilities, conditional on observed test statistic ("z-score") SNP. We use multiple logistic...