A5101826866- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Peptidase Inhibition and Analysis
- Cancer Cells and Metastasis
- Muscle Physiology and Disorders
- Lung Cancer Research Studies
- Wound Healing and Treatments
- Endometrial and Cervical Cancer Treatments
- Eosinophilic Disorders and Syndromes
- Diabetic Foot Ulcer Assessment and Management
- Cervical Cancer and HPV Research
- Systemic Lupus Erythematosus Research
- Exercise and Physiological Responses
- Pleural and Pulmonary Diseases
- Occupational and environmental lung diseases
- Pressure Ulcer Prevention and Management
- Neonatal Respiratory Health Research
- Advanced Glycation End Products research
- Epigenetics and DNA Methylation
- Cancer Mechanisms and Therapy
- Cancer-related gene regulation
- Respiratory Support and Mechanisms
- NF-κB Signaling Pathways
- Medical Imaging and Pathology Studies
- Pneumonia and Respiratory Infections
Shenzhen Second People's Hospital
2025
Shenzhen University Health Science Center
2025
Yixing People's Hospital
2013-2024
Jiangsu University
2014-2024
Lanzhou University Second Hospital
2022-2024
Lanzhou University
2022-2024
Hainan Medical University
2024
Wenzhou Medical University
2020-2024
Dongyang People's Hospital
2020-2024
Guizhou Provincial People's Hospital
2024
Abstract Cachexia, characterized by muscle wasting, is a major contributor to cancer-related mortality. However, the key cachexins that mediate cancer-induced wasting remain elusive. Here, we show tumor-released extracellular Hsp70 and Hsp90 are responsible for tumor’s capacity induce wasting. We detected high-level constitutive release of associated with vesicles (EVs) from diverse cachexia-inducing tumor cells, resulting in elevated serum levels mice. Neutralizing Hsp70/90 or silencing...
Nasopharyngeal carcinoma (NPC), a malignancy highly prevalent in East and Southeast Asia, is primarily treated with radiotherapy (RT). However, hypoxia-induced radioresistance presents significant challenge. Nanozymes, nanomaterials catalase-like activity, have emerged as promising strategy for radiosensitization by converting elevated hydrogen peroxide the tumor microenvironment into oxygen. Despite their potential, effectively targeting hypoxic lesions has been difficult. Here, we identify...
Abstract Objectives In the present study, we aimed to assess prevalence and clinical significance of anti-Ro52 antibodies in a cohort patients with idiopathic inflammatory myopathy-associated interstitial lung disease (IIM-ILD) different myositis-specific autoantibodies (MSAs). Methods A 267 IIM-ILD patients, including 62 PM, 126 DM 79 clinically amyopathic (CADM) were retrospectively analysed this study. Clinical laboratory findings, pulmonary function tests (PFTs), HRCT patterns treatment...
Cancer-induced cachexia, characterized by muscle wasting, is a lethal metabolic syndrome with undefined etiology. Current consensus that multiple factors contribute to cancer-induced and therefore therapy requires combinational strategies. Here, we show Toll-like receptor 4 (TLR4) mediates wasting directly activating catabolism as well stimulating an innate immune response in mice bearing Lewis lung carcinoma (LLC), targeting TLR4 alone effectively abrogate wasting. Utilizing specific siRNAs...
Abstract Background Activation of type IIB activin receptor (ActRIIB) in skeletal muscle leads to atrophy because increased protein degradation. However, the intracellular signalling mechanism that mediates ActRIIB‐activated catabolism is poorly defined. Methods We investigated role p38β mitogen‐activated kinases (MAPK) mediating ActRIIB ligand A‐activated catabolic pathways C2C12 myotubes and mice with perturbation this kinase pharmacologically genetically. Results Treatment A or myostatin...
Idiopathic pulmonary fibrosis (IPF) is a progressive, eventually fatal disease. IPF characterized by excessive accumulation of the extracellular matrix (ECM) in alveolar parenchyma and progressive lung scarring. The pathogenesis whether ECM involved process remain unknown.To identify potential treatment target associated proteins that may be development IPF, we employed isobaric tag for relative absolute quantitation (iTRAQ) combined liquid chromatography-tandem mass spectrometry (LC-MS/MS)...
Abstract Background Although the morbidity and mortality rates associated with idiopathic pulmonary fibrosis (IPF) are high, there is still lack of powerful precise therapeutic options for IPF. Object Through in vitro model, this study sought to determine whether binding acetylated CCAAT/enhancer protein β (C/EBPβ) alpha-smooth muscle actin (α-SMA) promoter could affect activity latter as well assess if it essential epithelial-to-mesenchymal transition (EMT) extracellular matrix deposition...
Idiopathic pulmonary fibrosis (IPF) is an aging-associated disease with poor prognosis. The mechanisms underlying the role of alveolar epithelial cell (AEC) senescence in IPF remain poorly understood. We aimed to investigate if PTEN/Akt activates AEC induce fibrosis. investigated association between and cellular lung tissues from patients. As a result, decreased PTEN activated Akt pathway were found AECs fibrotic detected by immunohistochemistry (IHC) immunofluorescence (IF). Increased...
Exosomes are vesicles secreted by cells that contain a wide variety of biomolecules, including proteins or nucleic acids. MicroRNAs (miRNAs), which commonly found in exosomes, known to play important roles the pathophysiology endometriosis.This study investigated miRNA expression profile serum exosomes from women with endometriosis comparison normal controls as well possible role identified miRNAs pathogenesis endometriosis. diameter between 60 and 100 nm were their exosomal marker CD9...
Our studies were conducted to investigate the clinical and functional significance of tumor‐associated macrophages (TAMs) in cervical tumor lymphatic metastasis. We found that increase stroma is significantly associated with metastasis (p = 0.017), through performing immunohistochemical staining 111 samples (55 invasive squamous carcinomas uterine cervix, 27 intraepithelial neoplasms III, 29 normal cervix). The human endothelial cells (HLEC), which cultured conditioned medium cancer...
Sleep deprivation is a prevalent issue that impacts cognitive function. Although numerous neuroimaging studies have explored the neural correlates of sleep loss, inconsistencies persist in reported results, necessitating an investigation into consistent brain functional changes resulting from loss.
Muscle wasting is the key manifestation of cancer-associated cachexia, a lethal metabolic disorder seen in over 50% cancer patients. Autophagy activated cachectic muscle hosts along with ubiquitin-proteasome pathway (UPP), contributing to accelerated protein degradation and wasting. However, established signaling mechanism that activates autophagy response fasting or denervation does not seem mediate cancer-provoked skeletal myocytes. Here, we show p38β MAPK mediates activation tumor-bearing...
Existing biomarkers such as AST, ALT and hematocrit have been associated with severe dengue but evidence are mixed. Recently, interests in creatine kinase a biomarker risen. These represent several underlying pathophysiological processes dengue. Hence, we aimed to assess ALT, CK identification of the correlational relationship amongst common dengue.This was retrospective cohort study confirmed patients who were warded Kuala Lumpur Hospital between December 2014 January 2015. CK, hematocrit,...
Abstract Purpose To investigate how sleeve gastrectomy (SG), a typical operation of bariatric surgery, attenuated symptom, and progression diabetic kidney disease (DKD). Methods DKD model was induced by high-fat diet (HFD) combined with streptozocin in Wistar rats. SG performed, the group subjected to sham surgery served as control. The animals were euthanized 12 weeks after followed sample collection for subsequent experiment. HK-2, renal proximal tubular epithelial cell line derived from...
To replicate previously confirmed telomere-length loci in a Chinese Han population with coronary heart disease (CHD), and investigate these the possibility of age at onset CHD.1514 CHD patients 2470 normal controls were recruited. Medical data including age, sex, body mass index, lipid profiles, history hypertension, type 2 diabetes mellitus, dyslipidemia collected from all participants. Seven identified single-nucleotide polymorphisms (SNPs) related to leucocyte telomere length genotyped,...
Recently, mesenchymal stem cells (MSCs) are increasingly used as a panacea for multiple types of disease short effective treatment. Dozens clinical trials published demonstrated strikingly positive therapeutic effects MSCs. However, specific agent, little research has focused on the dynamic distribution MSCs after in vivo administration. In this study, we track systemically transplanted allogeneic bone marrow (BMSCs) normal rats through bioluminescence imaging (BLI) real time. Ex organ...
Abstract Background DAXX is a transcription repressor that has been implicated in several types of cancers, but its role the development gastric cancer remains unknown. Methods We analysed expression 83 pairs samples, including neoplastic and adjacent tissues, correlated levels with clinical stages. also investigated molecular mechanisms by which downregulation promotes growth using both vitro vivo models. Results was downregulated advanced samples. The inversely correlates stem cell markers...
Diffuse panbronchiolitis (DPB), a chronic inflammatory disease of the airway, is treated with macrolide antibiotics. The ability azithromycin to improve DPB prognosis, as detected by high-resolution computed tomography (HRCT) scans and lung function tests, has not been studied in large retrospective patients. Our study aims investigate effects on patients using tests radiologic images.Twenty-nine were studied; their medical records collected analyzed retrospectively. Patients hospitalized...