A5082363817- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inflammatory Myopathies and Dermatomyositis
- Medical Imaging and Pathology Studies
- Eosinophilic Disorders and Syndromes
- Occupational and environmental lung diseases
- Pulmonary Hypertension Research and Treatments
- Sarcoidosis and Beryllium Toxicity Research
- Pneumonia and Respiratory Infections
- Systemic Sclerosis and Related Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Occupational exposure and asthma
- Neonatal Respiratory Health Research
- Histiocytic Disorders and Treatments
- Cancer-related molecular mechanisms research
- Pleural and Pulmonary Diseases
- Ion channel regulation and function
- Tracheal and airway disorders
- Macrophage Migration Inhibitory Factor
- IL-33, ST2, and ILC Pathways
- Glycogen Storage Diseases and Myoclonus
- Peptidase Inhibition and Analysis
- Antifungal resistance and susceptibility
- Extracellular vesicles in disease
- Lysosomal Storage Disorders Research
- Skin Diseases and Diabetes
Nanjing Drum Tower Hospital
2015-2024
Nanjing University
2010-2024
Nanjing Medical University
2020-2024
Wuxi People's Hospital
2024
Tianjin Medical University General Hospital
2024
Nanjing University of Chinese Medicine
2023
Hefei First People's Hospital
2023
Creative Commons
2021
Fundación Juan March
2021
Respiratory Clinical Trials
2018
Polystyrene microplastics (PS-MPs) are emerging pollutants that absorbed by organisms. Due to their small volume and strong biological permeability, they affect the functions of cells. In recent years, several studies have detected PS-MPs in air samples, which may damage human respiratory system following inhalation. The Masson trichrome staining, immunofluorescence, western blotting assays were conducted analyze effects on pulmonary fibrosis. Alveolar epithelial injuries assessed through...
Abstract Idiopathic pulmonary fibrosis (IPF) is an aging‐associated disease with poor prognosis. Currently, there are no effective drugs for preventing the process. The mechanisms underlying role of alveolar epithelial cell (AEC) senescence in pathogenesis IPF remain poorly understood. We aimed to explore whether PTEN/NF‐κB activated AEC thus resulting lung fibrosis. First, we investigated association between activation and cellular tissues from patients. As a result, decreased PTEN, NF‐κB...
Abstract Objectives In the present study, we aimed to assess prevalence and clinical significance of anti-Ro52 antibodies in a cohort patients with idiopathic inflammatory myopathy-associated interstitial lung disease (IIM-ILD) different myositis-specific autoantibodies (MSAs). Methods A 267 IIM-ILD patients, including 62 PM, 126 DM 79 clinically amyopathic (CADM) were retrospectively analysed this study. Clinical laboratory findings, pulmonary function tests (PFTs), HRCT patterns treatment...
Abstract Background and objective Short telomere is a crucial risk factor for idiopathic pulmonary fibrosis ( IPF ). However, little known about the association between baseline length survival in . We aimed to determine whether associated with of Methods Leukocyte lengths were measured by quantitative polymerase chain reaction patients at time initial enrolment assessment N anjing D rum T ower H ospital A ffiliated M edical S chool U niversity. The primary endpoint was since their...
The efficacy of tofacitinib (TOF) in the early diagnosis melanoma differentiation-associated gene 5 (MDA5)-related interstitial lung disease (ILD) has been described. However, whether TOF exposure is associated with a reduced 1-year mortality rate remains undetermined.Patients diagnosed MDA5-ILD receiving or tacrolimus (TAC) treatment were included. A Cox proportional hazards model, which was adjusted for age, sex, smoking history, anti-MDA5 antibody titers, and concurrent use other...
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease tightly correlated with aging.The pathological features of IPF include epithelial cell senescence abundant foci highly activated fibroblasts.However, the underlying mechanism between fibroblast activation remain to be elucidated.In our study, we demonstrated that Nanog, as pluripotency gene, played an essential role in fibroblasts.In progression IPF, senescent cells could contribute fibroblasts via increasing...
Idiopathic pulmonary fibrosis (IPF) is an aging-associated disease with poor prognosis. The mechanisms underlying the role of alveolar epithelial cell (AEC) senescence in IPF remain poorly understood. We aimed to investigate if PTEN/Akt activates AEC induce fibrosis. investigated association between and cellular lung tissues from patients. As a result, decreased PTEN activated Akt pathway were found AECs fibrotic detected by immunohistochemistry (IHC) immunofluorescence (IF). Increased...
Background and Purpose Development of pulmonary fibrosis is associated with altered DNA methylation modifications fibrogenic gene expression. However, their causal relationships the underlying mechanisms remain unclear. This study investigates critical role aberration‐associated suppression peroxisome proliferator‐activated receptor‐γ (PPARγ) in fibrosis. Experimental Approach Expression PPARγ bioactive methyltransferases (DNMTs) promoter status were examined fibrotic lungs idiopathic (IPF)...
The purpose of this study was to determine the diagnostic and prognostic values serum KL-6 levels in Chinese patients with interstitial lung disease (ILDs).A total 1084 subjects including 373 cases ILDs, 584 non-ILD pulmonary diseases, 127 healthy individuals were recruited from three clinical centers China between January 2011 December 2013. A 106 undergoing treatments for ILDs Shanghai Pulmonary Hospital 2013 enrolled. Baseline posttreatment determined.Serum significantly higher than those...
Abstract Idiopathic pulmonary fibrosis (IPF) was considered as a telomere-mediated disease. TERT and TERC correlated with telomere length. Although telomerase gene mutations were associated IPF, majority patients did not carry mutations. The mechanism by which expression regulated in IPF are still unclear. In this study, we aimed to delineate the mechanisms that how protein alveolar epithelial cells (AECs) fibrosis. Here, found P16, P21 markers (αSMA Collagen-I) prominently increased lung...
Abstract Background and objective Idiopathic pulmonary fibrosis ( IPF ) is an age‐related disease the most common manifestation of telomere‐mediated disorders. Methods We collected detailed medical histories DNA samples from 100 patients seen at N anjing D rum T ower H ospital A ffiliated to M edical S chool U niversity. All had sporadic , with no family history reported. screened all for telomerase reverse transcriptase TERT RNA component TERC variants, measured their telomere lengths in...
Cryptogenic organizing pneumonia (COP) is characterized by good response to corticosteroids, but frequent relapses after reduction or cessation of treatment are noted. The incidence, risk factors relapse, and long-term outcomes patients with COP remain undetermined. Patients from September 2010 December 2017 were enrolled. Hospital office records used as data sources. Clinical information, lab examinations, chest radiographs, courses, follow-up collected. Relapse group was defined worsening...
Background Numerous studies showed that insulin resistance (IR) was associated with cancer risk. However, few investigated the relationship between IR and non-small cell lung (NSCLC). The aim of this study is to explore association triglyceride glucose (TyG) index, a simple surrogate marker IR, NSCLC Methods 791 histologically confirmed cases 787 controls were enrolled in present study. Fasting blood measured. TyG index calculated as ln [fasting triglycerides (mg/dl) ×fasting (mg/dl)/2]....
Millions of patients suffer from silicosis, but it remains an uncurable disease due to its unclear pathogenic mechanisms. Though the Nlrp3 inflammasome is involved in silicosis pathogenesis, inhibition classic downstream factors, Caspase-1 and Gsdmd, fails block pyroptosis cytokine release. To clarify molecular mechanism pathogenesis for new therapy, we examined samples genetic mouse models. We discovered alternative pyroptotic pathway which requires cleavage Gsdme by Caspases-3/8 addition...
Abstract Objectives In the present study, we aimed to assess clinical significance of cytokeratin 19 fragment (CYFRA21-1) in patients with anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive DM-interstitial lung disease (MDA5-DM-ILD). Methods A total 73 MDA5-DM-ILD were retrospectively analysed this work. Their characteristics, including manifestations, laboratory findings, peripheral blood lymphocyte subsets and function, compared between acute/subacute interstitial...
Abstract Genetic factors were identified to be associated with the development of idiopathic pulmonary fibrosis (IPF). We aimed investigate associations between mucin 5B ( MUC5B) and telomerase reverse transcriptase TERT ) polymorphisms telomere length (TL) honeycombing extent survival in a Chinese IPF cohort. Seventy-nine patients diagnosed enrolled. The extents high resolution CT scan (HRCT) quantitatively scored defined as mild (<10%), moderate (10–50%), severe (>50%) upon involving...
Objective: Vitamin D deficiency was associated with CTD-ILD and reduced lung function.We sought to confirm that lower level would be related shorter survival times.Results: The patients had (P<0.05).Among who have improved function after treatment, elevation of positively ΔFVC (%), ΔFEV1(%) ΔDLCO-SB (%).The median time high serum 25(OH)D significantly longer than the low group (16.5 months vs14.0 months, P=0.007).The identified as an independent prognostic factor a hazard ratio 0.869 (95% CI...
Acute fibrinous and organizing pneumonia (AFOP) is a unique pathological entity with intra-alveolar fibrin in the form of "fibrin balls" pneumonia. It was divided into rare idiopathic interstitial according to classification notified by American Thoracic Society/European Respiratory Society 2013. As entity, it still not well known recognized clinicians. We reviewed clinical features 20 patients AFOP diagnosed teaching hospital.The medical records biopsy-proven diagnosis were retrospectively...