A5089343645- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Acute Myeloid Leukemia Research
- Inflammatory Myopathies and Dermatomyositis
- Multiple Myeloma Research and Treatments
- Ion channel regulation and function
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Sarcoidosis and Beryllium Toxicity Research
- Eosinophilic Disorders and Syndromes
- Peptidase Inhibition and Analysis
- Kruppel-like factors research
- Histiocytic Disorders and Treatments
- Neonatal Respiratory Health Research
- Cancer-related gene regulation
- Antifungal resistance and susceptibility
- Occupational and environmental lung diseases
Nanjing Drum Tower Hospital
2022-2025
Sichuan University
2025
West China Second University Hospital of Sichuan University
2025
Pingdingshan University
2024
Idiopathic pulmonary fibrosis (IPF) is a fibrotic disease driven by both environmental and genetic factors. Epigenetics refers to changes in gene expression or cellular phenotype that do not involve alterations DNA sequence. KMT2A member of the SET family which catalyses H3K4 methylation. Through microarray single-cell sequencing data, we discovered KMT2A-positive fibroblasts were increased IPF lung tissues. level was bleomycin-induced mice tissues collected our centre. Mice with...
The efficacy of tofacitinib (TOF) in the early diagnosis melanoma differentiation-associated gene 5 (MDA5)-related interstitial lung disease (ILD) has been described. However, whether TOF exposure is associated with a reduced 1-year mortality rate remains undetermined.Patients diagnosed MDA5-ILD receiving or tacrolimus (TAC) treatment were included. A Cox proportional hazards model, which was adjusted for age, sex, smoking history, anti-MDA5 antibody titers, and concurrent use other...
Abstract Idiopathic pulmonary fibrosis (IPF) was considered as a telomere-mediated disease. TERT and TERC correlated with telomere length. Although telomerase gene mutations were associated IPF, majority patients did not carry mutations. The mechanism by which expression regulated in IPF are still unclear. In this study, we aimed to delineate the mechanisms that how protein alveolar epithelial cells (AECs) fibrosis. Here, found P16, P21 markers (αSMA Collagen-I) prominently increased lung...
Background Acute myeloid leukemia (AML) with hyperleukocytosis (HL) is a severe medical emergency associated high mortality rates and poor prognosis. Prompt urgent treatment crucial to address this emergency. This study aims elucidate appropriate diagnostic thresholds for HL investigate underlying mechanisms potential targeted therapies. Methods X-tile software was employed analyze white blood cell (WBC) count in AML patients using data from TCGA TARGET databases. METASCAPE Gene Set...
Abstract Background Diabetes mellitus (DM) has been found to be related lung fibrosis. However, the relationship between DM and idiopathic pulmonary fibrosis (IPF) remains uncertain. In this study, we aimed determine prevalence of in IPF whether is associated with survival IPF. Methods 415 patients were classified as two groups based on they combined or without DM. The medical records reviewed baseline characteristics times compared. adjusted Cox proportional hazards model was used...