A5100602391- Nanoplatforms for cancer theranostics
- Molecular Sensors and Ion Detection
- Carbon and Quantum Dots Applications
- Sulfur Compounds in Biology
- Fire dynamics and safety research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Advanced biosensing and bioanalysis techniques
- Medical Imaging and Pathology Studies
- Cancer-related gene regulation
- Impact of Light on Environment and Health
- Benford’s Law and Fraud Detection
- Computability, Logic, AI Algorithms
- Nanocluster Synthesis and Applications
- Supramolecular Chemistry and Complexes
- Polydiacetylene-based materials and applications
- Graphene and Nanomaterials Applications
- Inorganic Fluorides and Related Compounds
- Calcium signaling and nucleotide metabolism
- Organic Electronics and Photovoltaics
- Photoacoustic and Ultrasonic Imaging
- Amino Acid Enzymes and Metabolism
- Luminescence and Fluorescent Materials
- Evacuation and Crowd Dynamics
- Photodynamic Therapy Research Studies
- Liver physiology and pathology
Second People’s Hospital of Yibin
2025
Qiqihar Medical University
2024
China Academy of Safety Sciences and Technology
2024
Shanxi University
2009-2024
Air Force Medical University
2017-2024
Taiyuan University of Technology
2022
Xijing Hospital
2020
Shanghai First People's Hospital
2017
Shanghai Jiao Tong University
2017
Academy of Military Medical Sciences
2015
Nanozyme technology as an emerging field has been successfully applied to chemical sensing, biomedicine, and environmental monitoring. It is very significant for the advance of this construct nanozymes with high catalytic activity by a simple method develop their multifunctional applications. Here, new type cobalt-doped carbon dots (Co-CDs) was designed using vitamin B12 citric acid precursors. The homogeneous cobalt doping at nuclear led Co-CDs show peroxidase-like resembling natural...
Intracellular peroxynitrite anions (ONOO-) and microenvironments (such as viscosity polarity) play an important role in maintaining redox homeostasis, regulating diffusion, transportation, signal transduction living cells. The abnormality of these factors is often closely related to various physiological/pathological processes. However, owing the lack suitable probes, simultaneous visualization ONOO-, viscosity, polarity ferroptosis cancer models has not been achieved. To meet urgent needs,...
Idiopathic pulmonary fibrosis (IPF) is a fibrotic disease driven by both environmental and genetic factors. Epigenetics refers to changes in gene expression or cellular phenotype that do not involve alterations DNA sequence. KMT2A member of the SET family which catalyses H3K4 methylation. Through microarray single-cell sequencing data, we discovered KMT2A-positive fibroblasts were increased IPF lung tissues. level was bleomycin-induced mice tissues collected our centre. Mice with...
Hydrogen peroxide (H2O2) overexpressed in mitochondria has been regarded as a key biomarker the pathological processes of various diseases. However, there is currently lack suitable mitochondria-targetable near-infrared (NIR) probes for visualization H2O2 multiple diseases, such PM2.5 exposure-induced lung injury, hepatic ischemia-reperfusion injury (HIRI), nonalcoholic fatty liver (NAFL), fibrosis (HF), and malignant tumor tissues containing clinical cancer patient samples. Herein, we...
Lysosomal viscosity is an essential microenvironment parameter in lysosomes, which closely associated to the occurrence and development of various diseases, including cancer. Thus, accurately quantifying lysosomal changes highly desirable for a better understanding dynamics biological functions lysosomes. In this study, lysosome self-targetable orange-red emissive carbon dots (OR-CDs) were rationally designed developed monitoring fluctuations. The enhanced fluorescence OR-CDs could be...
A fixture is a device that secures and holds workpiece to maintain its orientation position during manufacturing process, so the desired quality can be achieved. Although many researchers have worked on locating accuracy analysis tolerance towards automated generation of schemes for fixtures, most them focused part localization, while feature errors due geometrical inaccuracies dimensional deviations mass production are usually neglected. In current paper, study layout carried out with...
Neurotransmitter imbalance is an important pathological basis for epilepsy seizures. Acetylcholinesterase (AChE) as a key hydrolase in the cholinergic system directly affects metabolism of neurotransmitter. Unfortunately, owing to lack reliable situ imaging tools brain, association between AChE and has not been fully elucidated yet. Here, we rationally designed near-infrared (NIR) fluorescent probe (QXMC) by employing N,N-dimethyl carbamyl sensing group quinolinium-xanthene NIR skeleton....
Complex experimental design is a common problem in the preparation of theranostic nanoparticles, resulting poor reaction control, expensive production cost, and low experiment success rate. The present study aims to develop PEGylated bismuth (PEG-Bi) nanoparticles with precisely controlled one-pot approach, which contains only methoxy[(poly(ethylene glycol)]trimethoxy-silane (PEG-silane) oxide (Bi2O3). A targeted pyrolysis PEG-silane was achieved realize its roles as both reduction...
Abstract The current situation of self-built houses by villagers is prevalent in rural areas, where many construct their own residential dwellings based on personal needs and economic circumstances. These are typically constructed using basic materials traditional building techniques, often without adherence to strict regulations standards. As a result the lack professional knowledge technical guidance, structural integrity safety these compromised. In addition, firefighting facilities fire...
In recent years, a large number of incidents external fire spread up high rise buildings happened in the world. One main reasons is that combustible organic materials, EPS, Polyurethane, etc, are used thermal insulation system (ETIS) for energy conservation purpose. some incidents, materials couple with from window to make it impossible fighters prevent vertical and caused severe damage structures loss life property. this paper, typical wall hazards China described briefly, then relative...
Abstract To eliminate the influence of electrolytic capacitors on driving life high-power LED, a three-port LED without capacitor power supply based energy distribution is proposed. The difference between input terminal and output balanced by auxiliary DC-DC circuit to reduce ripple current. working principle topology switching mode analyzed in detail. According proposed topology, mechanism current low-frequency analyzed, control strategy suitable for specific implementation scheme key...