A5101815934- Plant-Derived Bioactive Compounds
- Biological Stains and Phytochemicals
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cancer Research and Treatments
- Prostate Cancer Diagnosis and Treatment
- Thyroid Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Genital Health and Disease
- Medical and Biological Sciences
- Phytochemistry and biological activity of medicinal plants
- Hernia repair and management
- Saffron Plant Research Studies
- Calcium signaling and nucleotide metabolism
- Flavonoids in Medical Research
- Nerve injury and regeneration
- Neurofibromatosis and Schwannoma Cases
- Martial Arts: Techniques, Psychology, and Education
- Spaceflight effects on biology
- Advanced Glycation End Products research
- Food Supply Chain Traceability
- Blood groups and transfusion
- Advanced Computational Techniques and Applications
- Syphilis Diagnosis and Treatment
Shanxi Medical University
2009-2025
Shenyang Institute of Automation
2024
Chinese Academy of Sciences
2024
State Key Laboratory of Robotics
2024
Shaoyang University
2024
Shanxi Provincial Cancer Hospital
2009-2023
Cancer Hospital of Chinese Academy of Medical Sciences
2023
Kobe University
2021-2022
Hangzhou First People's Hospital
2022
Huashan Hospital
2012
The identification of the complex spatial architecture immune cell infiltration and its interaction mechanisms within tumor ecosystems provides crucial insights into therapeutic responses to neoadjuvant therapy in muscle-invasive bladder cancer (MIBC). This study aims characterize features distinct cell-type niches microenvironment (TME) patients with varying therapy. We performed transcriptomic profiling on six MIBC specimens obtained from a registered clinical trial (ChiCTR2000032359),...
Background The intricate relationship between human health and gut microecology has emerged as a central theme in contemporary medical research. Postmenopausal osteoporosis, primarily driven by estrogen deficiency, remains major concern. Traditional Chinese herbal medicines have attracted significant interest for their promising role osteoporosis treatment. Methods effects of Isaria felina , derived from Cordyceps sinensis on postmenopausal rats are the focus this study. Adult female...
Lysosomal viscosity is an essential microenvironment parameter in lysosomes, which closely associated to the occurrence and development of various diseases, including cancer. Thus, accurately quantifying lysosomal changes highly desirable for a better understanding dynamics biological functions lysosomes. In this study, lysosome self-targetable orange-red emissive carbon dots (OR-CDs) were rationally designed developed monitoring fluctuations. The enhanced fluorescence OR-CDs could be...
Abstract Background Fractures heal through a process that involves angiogenesis and osteogenesis but may also lead to non-union or delayed healing. Bone marrow mesenchymal stem cells (BMSCs) have been reported play pivotal role in bone formation vascular regeneration the p75 neurotrophin receptor (p75NTR) as being an important regulator of osteogenesis. Herein, we aim determine potential mediation BMSCs by p75NTR Methods Rat were identified flow cytometry (FCM) detect cell cycle surface...
Copy number variation (CNV) is common in genomic regions encoding immune-related genes and can impact polygenic autoimmunity. FCGR3B CNV associated with susceptibility to systemic autoimmunity Caucasian populations. In this study, we examined patients the autoimmune disease lupus nephritis (LN) a Chinese population. The study includes 202 histologically verified LN 146 geographically matched healthy controls. To identify at FCGRB locus, quantitative polymerase chain reaction (PCR) was done...
This study aimed to determine the effect of brazilin on invasion and metastasis breast cancer. The cancer MDA-MB-231 4T1 cells were treated with investigate proliferation using cell assay, wound healing transwell assay. BALB/C mice randomized into normal, model, positive control, Sappan L. extract groups (n = 6/group). injected via caudal veins establish a lung model subcutaneous injection xenograft model. Metastatic nodules surface, survival rates visceral indices evaluated. Subcutaneous...
To assess the efficacy and safety of ultrasound (US)-guided high-intensity focused (HIFU) ablation for treatment unresectable recurrent intra-abdominal desmoid tumors. From June 2014 to March 2020, 15 patients with consecutive diseases that pathologically proven be tumors had undergone US-guided HIFU ablation. All underwent contrast-enhanced magnetic resonance imaging before after treatment. Nonperfused volume ratio was used evaluate effect therapy. Intraprocedural postprocedural adverse...
This study aimed to investigate the therapeutic effect of Cordyceps sinensis-derived fungus Isaria felina on experimental autoimmune thyroiditis (EAT). A NaI-induced EAT mouse model was established. The mice received oral administration vehicle, low-dose (300 mg/kg), or high-dose (600 mg/kg) once a day for four weeks before euthanasia. Enzyme-linked immunosorbent assays (ELISA) performed measure serum thyroid-stimulating hormone (TSH) levels, thyroid antibodies, and cytokines. Hematoxylin...
Background: Ultrasound (US) is mostly used for diagnostic purpose but could be cancer treatments with a US intensity or frequency fitted to such purpose. Prostate (PC) has the highest prevalence in urological field, indications immune checkpoint inhibitors (ICIs) PC are limited very few cases. In this study, we compared antitumor effect of irradiation alone combined use and ICIs vitro vivo. Methods: cell line TRAMP-C2 cells were our experiments. irradiated pulse repeated frequencies (PRF) 1,...
Patient-derived xenograft (PDX) model becomes a more and important tool for tumor research. This study aimed to establish colorectal cancer PDX verify its applicability.Fresh human tissue was surgically removed subcutaneously inoculated into immunodeficient mice the model. Hematoxylin eosin (HE) staining immunohistochemical were used evaluate The successful selected efficacy of capecitabine in treating cancer.HE showed that could preserve histological characteristics primary tumor....
The purpose of the current study was to explore carboplatin‑induced sequential changes in gene expression and screen out key genes, which were associated with effects carboplatin on epithelial ovarian cancer (EOC). microarray dataset GSE13525 downloaded from Gene Expression Omnibus database, including 6 EOC cell samples separately treated at 24, 30 36 h (case group), phosphate‑buffered saline same time points (control group). A total 3 sets differentially expressed genes (DEGs) respectively...
Background: The polysaccharide extract of C. sinensis, Isaria felina (IF), has antitumor effects. Selenium (Se) can improve disease prevention and reduce the toxicity toxic elements, but effect Se-enriched IF on hepatoma remains unknown. Objective: To determine organic transformation Se compare effects between (IF-Se) xenograft H22 hepatoma-bearing mice. Methods: was added to solid-state culture medium, content detected by HPLC-ICP-MS. Forty-two Kunming mice were randomly divided into seven...
To evaluate the efficacy of an ultrasound-based quantitative method to diagnose liver fibrosis using a rat model. Ultrasonography was performed on livers 90 Sprague-Dawley rats with or without thioacetamide-induced fibrosis. The capsule thickness and 13 texture parameters gray level co-occurrence matrix were extracted from standard sonograms. After sacrifice, severity (S0-S4 classification) diagnosed by histopathology. Analysis variance correlation statistical tests used analyze differences...
Objective To compare the inhibitory effects to mice ascitic hepatoma (HepA) among hematoxylin,mitomycin,cisplatin,hydroxycamptothecine and other medicine in celiac chemotherapeutic route,probing into credibility of hematoxylin chemotherapy.Methods Mice HepA model was set up by inoculation strains.24 h after inoculation,intraperitoneal administration done,then raising as routine.Their body weights were measured regularly,living quality observed,mean survival times compared these groups.Having...
Background: Urinary bladder carcinoma is characterized by high post-operative recurrence rates. Sufu'ning lotion, prepared with Lignum Sappan, can reduce the of urinary carcinoma. Objectives: The present study describes a methodology for extracting and obtaining purity brazilin from sappan evaluates its effects on carcinoma, in vitro vivo . Materials Methods: was extracted sappan, purified identified. assessed tumor cell viability growth using human (T24) mouse (BTT) cancer lines. role...
In the field of sexually transmitted diseases, resistance and diversification causative organisms are becoming a problem. We report case in which course disease was complicated by doctor shopping.A man his 40s visited local for painful urination cloudy urine. Due to lack improvement symptoms after antibiotic treatment, he self-selected visit six hospitals just five months. He our clinic only few times then stopped coming.Doctor shopping, as well self-diagnosis self-treatment, will continue...
Journal Article Three Methyl-Histidine Excretion Following Severe Burn Injury in Children Get access R. L. Sheridan, MD, MD 1Massachusetts General Hospital and Shriners Burns Hospital, Boston, MA Search for other works by this author on: Oxford Academic Google Scholar K. Prelack, RD, MS, MS Y. Yong-Ming, PhD, PhD Xiao-Ming, D. Beffa, BS, BS E. Carter, Petras, RN, RN M. Lydon, G. Tompkins, ScD The of Care & Rehabilitation, Volume 23, Issue suppl_2, March-April 2002, Page S128,...
Abstract Brazilin possesses anticancer effects, but the mechanisms are poorly understood. This study investigated of brazilin‐induced cell death in T24 human bladder cancer line. Low serum culture and lactate dehydrogenase assay were used to confirm antitumor effect brazilin. Annexin V propidium iodide double staining, transmission electron microscopy, fluo‐3‐AM for Ca 2+ mobilization caspase activity performed identify type after brazilin treatment. Mitochondria membrane potentials measured...
Objective To observe the immunological effect of tumor cell vaccines to mouse hepatoma A(HepA) treated by Haematoxylin. Methods HepA was 0.1% Haematoxylin and made into three vaccines: vaccine with complete Freund' s adjuvant, incomplete adjuvant; without any adjuvants. Five times immunization were given grouped mice above vaccines, then active cells (1×105 for each mouse) inoculated intraperitoneal injection attack them; reckoning mean survival time (MST) mice, comparing immunoprotective...