A5030153308- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Inflammatory Myopathies and Dermatomyositis
- Neonatal Respiratory Health Research
- Eosinophilic Disorders and Syndromes
- Systemic Sclerosis and Related Diseases
- Congenital Diaphragmatic Hernia Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pneumonia and Respiratory Infections
- Sarcoidosis and Beryllium Toxicity Research
- Fungal Infections and Studies
- Pleural and Pulmonary Diseases
- Autoimmune and Inflammatory Disorders Research
- Lung Cancer Treatments and Mutations
- Inflammatory Biomarkers in Disease Prognosis
- Cancer therapeutics and mechanisms
- Respiratory and Cough-Related Research
- Atomic and Subatomic Physics Research
- Pulmonary Hypertension Research and Treatments
- Adolescent and Pediatric Healthcare
- IL-33, ST2, and ILC Pathways
- Antifungal resistance and susceptibility
- Immune Cell Function and Interaction
- Asthma and respiratory diseases
- Colorectal Cancer Treatments and Studies
Nanjing Drum Tower Hospital
2018-2025
Nanjing Medical University
2018-2025
Nanjing University
2022
Abstract Objectives In the present study, we aimed to assess prevalence and clinical significance of anti-Ro52 antibodies in a cohort patients with idiopathic inflammatory myopathy-associated interstitial lung disease (IIM-ILD) different myositis-specific autoantibodies (MSAs). Methods A 267 IIM-ILD patients, including 62 PM, 126 DM 79 clinically amyopathic (CADM) were retrospectively analysed this study. Clinical laboratory findings, pulmonary function tests (PFTs), HRCT patterns treatment...
Transbronchial lung cryobiopsy (TBLC) has been identified to be a new technique diagnosis interstitial disease (ILD). The study was conducted investigate the safety and diagnostic accuracy of TBLC contrast with transbronchial biosy (TBLB) in patients ILD. In cross-sectional comparative study, suspected ILD who underwent or TBLB were evaluated from June 2018 September 2022 Nanjing drum tower hospital. procedure details clinical multidisciplinary discussion (MDD) based on clinical,...
Abstract Objectives In the present study, we aimed to assess clinical significance of cytokeratin 19 fragment (CYFRA21-1) in patients with anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive DM-interstitial lung disease (MDA5-DM-ILD). Methods A total 73 MDA5-DM-ILD were retrospectively analysed this work. Their characteristics, including manifestations, laboratory findings, peripheral blood lymphocyte subsets and function, compared between acute/subacute interstitial...
Background. Pulmonary alveolar proteinosis (PAP) is a rare disorder which characterized by the accumulation of excessive surfactant lipids and proteins in macrophages alveoli. Oral statin therapy has been reported to be novel for PAP with hypercholesterolemia. We aimed evaluate safety efficacy oral without Methods. In prospective real-world observational study, 47 patients hypercholesterolemia were screened. was initiated as these 12 months follow-up. Results. Forty completed study. 26 (65%)...
Abstract Objective Interstitial lung disease (ILD) is a severe complication of connective tissue (CTD) that can significantly impact patients' prognosis and quality life. However, the current diagnostic arena lacks reliable biomarkers for detecting monitoring progression exacerbation CTD-ILD. This study aimed to investigate clinical value 12 serum cytokines in diagnosis CTD-ILD prediction risk acute (AE) this disease. Methods was cross-sectional investigation. Ninety-one hospitalized CTD...
Background Anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis with interstitial lung disease (anti-MDA5 DM-ILD) is a high mortality. We sought to develop an effective and convenient prediction tool estimate mortality risk in patients anti-MDA5 DM-ILD inform clinical decision-making early. Methods This prognostic study included Asian hospitalized at the Nanjing Drum Hospital from December 2016 2020. Candidate laboratory indicators were retrospectively collected....
Several serum markers were reported to reflect the severity of pulmonary alveolar proteinosis (PAP). The aim this study is investigate a reliable and facile marker access monitor clinical course PAP in large cohort.PAP patients from January 2010 June 2018 enrolled. Hospital records used as data sources. levels various indicators detected. We evaluated correlation between function test results variables.Diffusion capacity for carbon monoxide (DLCO) level was positively correlated with...
Objective. The aim of this study was to evaluate the diagnostic and prognostic value red blood cell distribution width (RDW) in patients with connective tissue disease-associated interstitial lung disease (CTD-ILD). Methods. We retrospectively reviewed 213 CTD-ILD 97 CTD without ILD from February 2017 2020. Hospital office records were used as data sources. followed up. Results. Patients had significantly higher RDW than those ( <math xmlns="http://www.w3.org/1998/Math/MathML" id="M1">...
The high-resolution computed tomography (HRCT) score is an important component of the severity and prognosis pulmonary alveolar proteinosis (SPSP). However, HRCT in SPSP only considers extent opacity, which insufficient.We retrospectively evaluated scores for 231 patients with autoimmune (APAP) from three centers China Alliance Rare Diseases. SPSPII was created based on overall density extent, incorporating SPSP. APAP assessed using disease (DSS), SPSP, to determine strengths weaknesses...
Pulmonary alveolar proteinosis (PAP) is a rare disorder characterized by the accumulation of excessive surfactant lipids and proteins in macrophages alveoli. Oral statin therapy novel treatment for PAP with hypercholesterolemia. However, this has never been described patient without Here, we present case successful atorvastatin possibly unclassified hypercholesterolemia who responded poorly to whole lung lavage inhaled granulocyte-macrophage colony-stimulating factor. After 18 months...
High-resolution computed tomography (HRCT) plays an important role in accessing the severity of pulmonary alveolar proteinosis (PAP). Visual evaluation changes between two HRCT scans is subjective. This study was conducted to quantitatively evaluate lung burden patients with PAP using HRCT-based automated deep-learning method following 12 months statin therapy.In this prospective real-world observational study, who underwent chest were evaluated from November 28, 2018, April 12, 2021. Oral...
Abstract The study aimed to evaluate the clinical and imaging features of critically ill patients with interstitial lung disease (ILD) treated in respiratory intensive care unit (RICU) assess prognostic effects these factors. A total 160 severe ILD admitted RICU were finally enrolled this study. clinical, follow-up data them studied retrospectively. in-hospital mortality 43.1% 63.8% respectively. By multivariate cox regression analysis, shock (OR = 2.39, P 0.004), pulmonary fibrosis on CT...
Bilirubin exerts antioxidant activity that has been associated with respiratory diseases. However, the relationship between serum bilirubin levels and idiopathic pulmonary fibrosis (IPF) is not clear. Therefore, in this study, we evaluated severity as well prognosis of IPF. One hundred forty-six patients IPF 69 healthy individuals control group were enrolled a derivation cohort. Routine blood examination function tests performed measured. To validate value to predict survival IPF, 40...
Abstract Fibrosing interstitial lung disease (ILD) can cause high mortality and sensitive evaluation of fibrosing ILD could be critical. The aim this study is to develop a scoring system predict prognosis ILD. 339 patients with were enrolled as derivation cohort. Cox multiple regression analysis indicated that smoking history (HR = 3.826, p 0.001), age(HR 1.043, 0.015), CEA(HR 1.059, 0.049),CYFRA21-1(HR 1.177, 0.004) DLCO% predicted 0.979, 0.032) independent prognostic factors for clinical...
Abstract Background: Soluble mannose receptor, sCD206, is a marker of alternatively activated macrophages. Activated macrophages play important roles in connective tissue disease (CTD) and lung fibrosis. Interstitial (ILD) common complication CTD, which leads to poor prognosis, especially pattern with usual interstitial pneumonia (UIP). Similarly, idiopathic pulmonary fibrosis (IPF) also characterized by UIP. Compared IPF, the prognosis CTD-associated UIP tightly correlated early treatment....
Nonspecific interstitial pneumonia (NSIP) is a common histopathologic pattern of idiopathic (IIP). A standard protocol for the treatment NSIP has not been issued because lacking randomized controlled studies.Although it widely acknowledged that glucocorticoid and immunosuppressive agents are rational therapies NSIP, most choice prescription solely glucocorticoid.We reviewed related literature describes therapy nonspecific to investigate possible consensus mechanisms therapy.In addition,...
Background: Overexpression of human epididymis protein 4 (HE4) was previously described in idiopathic pulmonary fibrosis (IPF) and cystic (CF), but whether serum HE4 concentrations can be considered a potential biomarker connective tissue diseases (CTDs) with the usual interstitial pneumonia phenotype (UIP-CTDs) is still unknown.Method: A total 55 CTD patients UIP 52 healthy controls were enrolled this study. The levels Krebs von den Lungen-6 (KL-6) evaluated both cohorts. In addition,...
Abstract Fibrosing interstitial lung disease (ILD) can cause high mortality and sensitive evaluation of fibrosing ILD could be critical. The aim this study is to develop a scoring system predict prognosis ILD. We retrospectively reviewed 339 patients admitted Nanjing Drum Tower Hospital from February 2017 2020. All were followed up until September Cox multiple regression analysis indicated that smoking history (HR=3.826,...
Abstract Lung cancer is a malignant tumor with high incidence and mortality in China. Furthermore, non-small cell lung cancer(NSCLC) accounts for more than 85%. About 30-40% of Asian populations carry epidermal growth factor receptor (EGFR) gene mutations. EGFR mutations mainly occur exon 18-21, the common are 19 deletions (19del), L858R, which all sensitive to tyrosine kinase inhibitors(EGFR-TKIs). Nevertheless, efficiency EGFR-TKIs on L861R remains unknown. In this article, we report...
Objectives: The prognosis of anti-melanoma differentiation-associated gene (MDA5) antibody-positive dermatomyositis (DM)-interstitial lung disease (ILD) (anti-MDA5-positive DM-ILD) is often poor, especially in rapidly progressive interstitial (RPILD). So far there has been no established therapy. This study evaluated the efficacy and safety pharmacological treatments for anti-MDA5-positive DM-ILD.Methods: retrospective comprised 87 DM-ILD patients. We reviewed clinical characteristics,...
Background: Anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis with interstitial lung disease (anti-MDA5 DM-ILD) is a rare, rapidly progressive associated an abysmal prognosis. Because few prognostic prediction models for this are available, we undertook study to develop tool estimate mortality risk in patients anti-MDA5 DM-ILD and inform clinical decision making.Methods: We identified who underwent treatment between December 2016 June 2021 the Nanjing Drum...
Abstract Familial hemophagocytic lymphohistiocytosis (FHL) is a genetically heterogeneous disorder which less typical in adults than pediatric patients. In this study, we reported rare case of adult-onset FHL3 with progressive lymphocytosis and lymphocytic interstitial pneumonia (LIP). A 20-year old female was admitted to our institution for persistent cough fever. chest high-resolution computed tomography (HRCT) scan showed diffuse bilateral ground glass opacities (GGO). lung biopsy...
Abstract Objectives: The prognosis of anti-melanoma differentiation-associated gene (MDA5) antibody-positive dermatomyositis (DM)-interstitial lung disease (ILD) (anti-MDA5 -positive DM-ILD) is often poor, especially in rapidly progressive interstitial (RPILD). So far there no established therapy. This study evaluated the efficacy and safety pharmacological treatments for anti-MDA5-positive DM-ILD. Methods: retrospective comprised 87 DM-ILD patients. We reviewed clinical characteristics,...