A5102751112- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Nuts composition and effects
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Lung Cancer Treatments and Mutations
- Renal cell carcinoma treatment
- Pharmacogenetics and Drug Metabolism
- Mycobacterium research and diagnosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immunotherapy and Immune Responses
- Aquatic Ecosystems and Phytoplankton Dynamics
- Nanoparticles: synthesis and applications
- Telomeres, Telomerase, and Senescence
- Cancer Immunotherapy and Biomarkers
- Skin Protection and Aging
- Peanut Plant Research Studies
- Effects and risks of endocrine disrupting chemicals
- Psoriasis: Treatment and Pathogenesis
- Drug Transport and Resistance Mechanisms
- Vitamin D Research Studies
- Acne and Rosacea Treatments and Effects
- Reproductive Biology and Fertility
Southeast University
2014-2024
Jiangsu Cancer Hospital
2021
Nanjing Medical University
2021
Southeast University
2014
Brigham and Women's Hospital
2011
Beth Israel Deaconess Medical Center
2011
Harvard University
2011
Accumulating evidence has highlighted the important roles of long non-coding RNAs (lncRNAs) acting as competing endogenous (ceRNAs) in tumor biology. However, cancer specific lncRNAs lncRNA-related ceRNA network lung adenocarcinoma (LUAD) are still unclear. In present study, 465 RNA sequencing profiles LUAD patients were obtained from genome atlas (TCGA) database, which provides large sample data free charge, and 41 lncRNAs, 25 miRNAs 1053 mRNAs (fold change >2, p<0.05) identified. Then,...
Abnormal expression of long non-coding RNAs (lncRNAs) have been shown to play an important role in tumor biology. The Cancer Genome Atlas (TCGA) platform is a large sample sequencing database lncRNAs, and further analysis the associations between these data patients' clinical related information can provide new approaches find functions lncRNA. In present study, 361 RNA profiles gastric cancer (GC) patients were selected from TCGA. Then, we constructed lncRNA-miRNA-mRNA competitive...
The risk of lung cancer among night-shift workers is unknown. Over 20 years follow-up (1988–2008), we documented 1,455 incident cancers 78,612 women in the Nurses' Health Study. To examine relationship between rotating work and risk, used multivariate Cox proportional hazard models adjusted for detailed smoking characteristics other factors. We observed a 28% increased with 15 or more spent working night shifts (multivariate relative (RR) = 1.28, 95% confidence interval (CI): 1.07, 1.53;...
Increasing evidence indicates that exposure to microcystin-LR (MC-LR) can cause kidney damage. However, the association between MC-LR and chronic disease (CKD) risk in humans has not been studied. Therefore, we conducted a population-based case–control study involving 135 CKD cases matched controls central China analyzed effects of alone as well combined with known factor cadmium (Cd). Compared lowest quartile exposure, highest had 6.56-fold (95% confidence interval [CI]: 2.46, 17.51)...
Small-sized titanium dioxide (TiO2) nanoparticles (< 10 nm) are widely used in both industry and daily life due to their enhanced thermomagnetic photocatalytic properties surface activity. However, increasing use increases the health risk of people exposed these particles, either occupationally or environmentally. This study was performed evaluate effect small-sized TiO2 on immune function rat pulmonary alveolar macrophages vivo. Forty-two rats were intra-tracheally instilled with 0.5, 5 50...
// Chengyun Li 1 , Geyu Liang Sheng Yang Jing Sui Wenzhuo Yao Xian Shen Yanqiu Zhang Hui Peng Weiwei Hong Siyi Xu Wenjuan Wu Yancheng Ye 2 Zhiyi Wenhua Lihong Yin and Yuepu Pu Key Laboratory of Environmental Medicine Engineering, Ministry Education, School Public Health, Southeast University, Nanjing, Jiangsu 210009, P.R. China Gansu Wuwei Tumor Hospital, Wuwei, 733000, Correspondence to: Liang, email: lianggeyu@163.com Keywords: gastric cancer, lncRNA, UCA1, progression, molecular mechanism...
Recent reports have shown that vitamin D status was inversely associated with the risk of various cancers. However, few studies examined association between levels and skin cancer.We prospectively evaluated baseline plasma 25(OH)D incident squamous cell carcinoma (SCC) basal (BCC) among 4,641 women from Nurses' Health Study (NHS) NHS II 510 BCC cases 75 SCC cases. We used multivariate logistic regression models to calculate odds ratios (ORs) 95% confidence intervals (CIs).Plasma were...
Emerging evidence indicates that long non-coding RNAs (lncRNAs) play a crucial role in predicting survival for gastric cancer (GC) patients. This study aims to identify lncRNA-related signature evaluating the overall of 379 GC patients from The Cancer Genome Atlas (TCGA) database. associations between outcome and expression lncRNAs were evaluated by univariate multivariate Cox proportional hazards regression analyses. Four (LINC01018, LOC553137, MIR4435-2HG, TTTY14) identified as...
Abstract Background Lung adenocarcinoma (LUAD), mainly originated in lung glandular cells, is the most frequent pathological type of cancer and 5‐year survival rate LUAD patients still very low. Therefore, we aim to identify a long noncoding RNA (lncRNA)–related signature as sensitive novel prognostic biomarkers. Methods The associations between outcome intersection lncRNAs were obtained from Cancer Genome Atlas (TCGA) database. By univariate multivariate Cox analyses, key identified...
This study aims to analyze the scientific output of long noncoding RNA (lncRNA) research and construct a model evaluate publications from past decade qualitatively quantitatively.Publications 2007 2016 were retrieved Web Science Core Collection database. Microsoft Excel CiteSpace IV software used publication outputs, journals, countries, institutions, authors, citation counts, ESI top papers, H-index, frontiers.A total 3,008 papers on lncRNA identified published by June 17, 2017. The...
Abstract Accumulating evidence implies that long noncoding RNA s (lnc s) play a crucial role in predicting survival for Hepatocellular carcinoma ( HCC ) patients. This study aims to capture the current research hotspots of , based on analysis publications related from 2013 2017, and identify novel lnc signature prognosis through data mining The Cancer Genome Atlas TCGA ). “Prognosis” “biomarker” were located core hotspot. Moreover, was top one frontier research. associations between outcome...
Abstract Long noncoding RNA (lncRNA) has played the important function in regulation of various biological processes and diagnostic value been widely appreciated. In present study, we have found that LOC101928316 was significantly downregulated gastric cancer (GC) tissues specimen, GC cell lines, associated with patients tumor, node, metastasis (TNM) stage degree differentiation ( P ＜ 0.05). overexpression can inhibit SGC‐7901 migration, invasion, proliferation ＜0.05). molecular mechanism...
Cervical cancer (CC) is a common gynecological malignancy in women worldwide. Using an RNA sequencing profile from The Cancer Genome Atlas (TCGA) and the CC patient information, aim of present study was to identify potential long non‑coding (lncRNA) biomarkers using bioinformatics analysis building competing endogenous (ceRNA) co‑expression network. Results indicated several CC‑specific lncRNAs, which were associated with clinical information selected some them for validation evaluated their...
Esophageal squamous cell carcinoma (ESCC) represents one of the most common malignancies and is fifth leading cause cancer-related deaths. Long intergenic non-coding RNAs (lincRNAs) have been suggested to be dysregulated in various types cancers, a growing number lincRNAs implicated functional ESCC progression. In this study, we examined role linc00941 progression explored underlying molecular mechanisms. The bioinformatics analysis identified up-regulation tissues. Further
As a representative item of chemical carcinogen, MNNG is closely associated with the onset gastric cancer (GC), where N6-methyladonosine (m6A) RNA methylation recognized as critical epigenetic event. In our previous study, we found that m6A modification by methyltransferase METTL3 was up-regulated in MNNG-exposed malignant GES-1 cells (MC cells) compared to control vitro, and long non-coding SNHG7 downstream target METTL3. However, functional role mediating axis MNNG-induced GC remains...
Abstract Cutaneous melanoma ( CM ) is the most malignant tumor of skin cancers because its rapid development and high mortality rate. Long noncoding RNA s (lnc s), which play essential roles in tumorigenesis metastasis interplay with micro (mi s) mRNA s, are hopefully considered to be efficient biomarkers detect deterioration during progression improve prognosis. Bioinformatics analysis was fully applied predict vital lnc associated mi eventually constructed competing endogenous (ce network...
Abstract Lung squamous cell carcinoma (LUSC) is one of the main histological types lung cancer with high mortality. The role microRNA‐486‐5p in LUSC remains unclear. In current study, aim was to explore miR‐486‐5p expression and its LUSC. significantly low‐expressed patients from Cancer Genome Atlas database, which further confirmed Gene Expression Omnibus patients’ tissues, different lines by quantitative real‐time polymerase chain reaction, high‐throughput gene sequencing data tissues mice...
Papillary thyroid carcinoma (PTC), the most frequent type of malignant tumor, lacks novel and reliable biomarkers patients' prognosis. In current study, we mined The Cancer Genome Atlas (TCGA) to develop lncRNA signature PTC.The intersection PTC lncRNAs was obtained from TCGA database using integrative computational method. By univariate multivariate Cox analysis, key were identified construct prognostic model. Then, all patients divided into high-risk group low-risk perform Kaplan-Meier...
Abstract Genetic factors were identified to be associated with the development of idiopathic pulmonary fibrosis (IPF). We aimed investigate associations between mucin 5B ( MUC5B) and telomerase reverse transcriptase TERT ) polymorphisms telomere length (TL) honeycombing extent survival in a Chinese IPF cohort. Seventy-nine patients diagnosed enrolled. The extents high resolution CT scan (HRCT) quantitatively scored defined as mild (<10%), moderate (10–50%), severe (>50%) upon involving...