A5090468701- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Congenital Diaphragmatic Hernia Studies
- Cerebral Palsy and Movement Disorders
- Neuroscience of respiration and sleep
- Family and Disability Support Research
- Infant Development and Preterm Care
- Infective Endocarditis Diagnosis and Management
- Child Nutrition and Feeding Issues
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Obstructive Sleep Apnea Research
- Genetics and Neurodevelopmental Disorders
- Respiratory viral infections research
- Respiratory and Cough-Related Research
- Cystic Fibrosis Research Advances
- Cardiac Valve Diseases and Treatments
- Pneumonia and Respiratory Infections
- Neurogenetic and Muscular Disorders Research
- Acute Myocardial Infarction Research
- Infectious Aortic and Vascular Conditions
- Tracheal and airway disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Genetic Syndromes and Imprinting
- Epigenetics and DNA Methylation
- Sleep and related disorders
The Kids Research Institute Australia
2016-2025
Princess Margaret Hospital for Children
2016-2025
Perth Children's Hospital
2018-2025
The University of Western Australia
2016-2025
Curtin University
2015-2024
SleepMed
2024
University of Bristol
1988-2022
St Vincent's Hospital
2011-2021
The University of Melbourne
1972-2021
West Australian Sleep Disorders Research Institute
2021
Improved survival following extreme preterm birth complicated by bronchopulmonary dysplasia (BPD) is resulting in an increasing number of affected infants surviving to adulthood. The aim the present pilot study was describe functional and structural pulmonary sequelae moderate severe BPD a population adult survivors. All babies were cared for at one institution (King Edward Memorial Hospital, Subiaco, Australia). Subjects born between 1980 1987 with birthweight <1,500 g requiring...
<h3>Rationale</h3> Survivors of preterm birth are at risk chronic and lifelong pulmonary disease. Follow-up data describing lung structure function scarce in children born during the surfactant era. <h3>Objectives</h3> To obtain comprehensive on mid-childhood from survivors birth. We aimed to explore relationships between structure, respiratory morbidity as well early life contributors poorer childhood outcomes. <h3>Methods</h3> Lung was tested 9–11 years term (controls) ≤32 weeks gestation....
Respiratory illness is the leading cause of mortality in children with cerebral palsy (CP). Although risk factors for developing chronic respiratory have been identified, comprehensive clinical care recommendations prevention and management do not currently exist. We invited over 200 clinicians researchers from multiple disciplines expertise CP to develop using a modified Delphi method on basis RAND Corporation–University California Los Angeles Appropriateness Method. These are intended use...
Abstract Background Neuroendocrine cell hyperplasia of infancy (NEHI) is a recently described children's interstitial lung disease (chILD) disorder unknown etiology. It manifests clinically with tachypnea, retractions, hypoxemia, and crackles. The characteristic radiographic appearance consists pulmonary hyperexpansion ground‐glass densities on high‐resolution computed tomography (HRCT). Lung histology shows bombesin‐immunopositive neuroendocrine cells within distal bronchioles alveolar...
Objective To determine the early predictors of respiratory hospital admissions in young people with cerebral palsy (CP). Design A 3-year prospective cohort study using linked data. Patients Children and CP, aged 1 to 26 years. Main outcome measures Self-reported carer-reported symptoms were (as defined by International Statistical Classification Diseases Related Health Problems 10th Revision codes) during following 3 Results 482 participants (including 289 males) recruited. They years (mean...
To determine the relationships between respiratory symptoms, lung function, and neonatal events in young preterm children.Preterm children (<32 w gestation), classified as bronchopulmonary dysplasia (BPD) or non-BPD, healthy term controls were studied. Lung function was measured by forced oscillation technique (respiratory resistance [Rrs] reactance [Xrs]) spirometry. Respiratory symptom questionnaires administered.One hundred fifty (74 BPD, 44 32 controls) 4-8 years (median Z-score [10,90th...
To identify whether abnormal electroencephalography (EEG) connectivity is present before the onset of epileptic spasms (ES) in infants with tuberous sclerosis complex (TSC).
Torpor is a naturally occurring, hypometabolic, hypothermic state engaged by wide range of animals in response to imbalance between the supply and demand for nutrients. Recent work has identified some key neuronal populations involved daily torpor induction mice, particular, projections from preoptic area hypothalamus dorsomedial (DMH). The DMH plays role thermoregulation, control energy expenditure, circadian rhythms, making it well positioned contribute expression torpor. We used...
The potential death toll of worst-case extreme heat events is crucial for climate risk analysis and adaptation planning. We estimate this quantity Europe using machine learning to calculate the intensity historical waves if they occur at present or future global temperatures, combined with empirical exposure-response functions quantify resulting mortality. Each event projected generate tens thousands excess deaths. For example, July 1994 August 2003 meteorological conditions recur current...
Understanding the mortality effects of most extreme heat events is central to climate change risk analysis and adaptation decision-making. Accurate representation these impacts requires accounting for prolonged sequences hot days on mortality, in that due anthropogenic forcing, potential compensating heat. Here, we revisit August 2003 wave France, a canonical event region with rich data, understand influences. We find standard exposure-response functions underpredict excess deaths by 60%,...
Chronic neonatal lung disease (CNLD) is defined as a supplemental oxygen requirement beyond 36 weeks' postmenstrual age, with more severely affected infants requiring full-term-equivalent age. Low-flow facilitates discharge from hospital of CNLD who develop hypoxia in air. There lack data on the most appropriate minimum mean target saturation (Spo2) level. Reflecting variety clinical practices and infant comorbidities (frequency desaturation, presence pulmonary hypertension, retinopathy...
Sleep disturbances are debilitating for individuals with Rett syndrome (RTT) and their families yet the evidence base management is poor. We investigated strategies relationships sleep problems. Data were provided by 364/461 (79%) a child RTT registered International Phenotype Database. Logistic regression models used to investigate between impacts of problems on family age group, mutation type, medication hygiene score. Linear estimate association disorders initiating maintaining (DIMS)...
The respiratory outcomes for adult survivors of preterm birth in the postsurfactant era are wide-ranging with prognostic factors, especially those encountered after neonatal period, poorly understood.
A retrospective review was carried out of 11 consecutive patients with the Pierre Robin sequence referred to a tertiary paediatric referral centre over five year period from 1993 1998. Ten were diagnosed significant upper airway obstruction; seven these presented late at between 24 and 51 days age. Failure thrive occured in six infants time presentation, strong indicator severity obstruction. Growth normalised on treatment obstruction nasopharyngeal tube placement. All children had been...
<h3>Introduction</h3> The tissue changes associated with spectrum of rotator cuff tendinopathy are poorly understood. aim this study was to describe the characteristics onset and progression by using a novel, ultrasound-guided biopsy technique obtain samples from supraspinatus tendon in several accurately phenotyped groups representing normal, healthy through patients full thickness tear tendon. <h3>Methods</h3> Participants were grouped ultrasound or arthroscopic diagnosis integrity...