A5053108521- Neuroscience of respiration and sleep
- Circadian rhythm and melatonin
- Sepsis Diagnosis and Treatment
- Spaceflight effects on biology
- Clinical Nutrition and Gastroenterology
- Hearing, Cochlea, Tinnitus, Genetics
- Mitochondrial Function and Pathology
- Nutrition and Health in Aging
- Intensive Care Unit Cognitive Disorders
- Diet and metabolism studies
- Child and Adolescent Psychosocial and Emotional Development
- Ultrasound in Clinical Applications
- Respiratory Support and Mechanisms
- Cardiac Ischemia and Reperfusion
- Machine Learning in Healthcare
- Intracerebral and Subarachnoid Hemorrhage Research
- Anesthesia and Neurotoxicity Research
- Thermoregulation and physiological responses
- Neuroendocrine regulation and behavior
- Malaria Research and Control
- Muscle Physiology and Disorders
- Cardiac Arrest and Resuscitation
- Muscle and Compartmental Disorders
- Heart Rate Variability and Autonomic Control
- Dietary Effects on Health
University of Bristol
2011-2025
University of Alaska Fairbanks
2022
Bury College
2019
University College London
2019
Guy's and St Thomas' NHS Foundation Trust
2015-2016
St Thomas' Hospital
2016
Shoklo Malaria Research Unit
2009
Torpor is a naturally occurring, hypometabolic, hypothermic state engaged by wide range of animals in response to imbalance between the supply and demand for nutrients. Recent work has identified some key neuronal populations involved daily torpor induction mice, particular, projections from preoptic area hypothalamus dorsomedial (DMH). The DMH plays role thermoregulation, control energy expenditure, circadian rhythms, making it well positioned contribute expression torpor. We used...
During hibernation, animals enter torpor, a reversible physiological state typically characterised by reductions in core temperature, heart rate and oxygen consumption. Species that this hypothermic hypometabolic are highly tolerant of ischaemia-reperfusion injury. Consequently, there is growing interest utilizing aspects torpor for clinical applications, such as protection from injury during stroke or myocardial infarction. It currently unknown, however, if torpor-like protective do not...
An impaired capacity of muscle to regenerate after critical illness results in long-term functional disability. We previously described a rat peritonitis model that gastrocnemius displays near-normal histology whereas soleus demonstrates necrotizing phenotype. thus investigated the link between phenotype myopathy and proteasome activity these two limb muscles. studied male Wistar rats underwent an intraperitoneal injection fungal cell wall constituent zymosan or n-saline as sham-treated...
Introduction Over half of patients who spend >48 hours in the intensive care unit (ICU) are fed via a nasogastric (NG) tube. Current guidance recommends continuous delivery feed throughout day and night. Emerging evidence from healthy human studies shows that NG feeding an intermittent pattern (rather than continuous) promotes phasic hormonal, digestive metabolic responses important for effective nutrition. It is not yet known whether this will translate to critically ill population....
We present a pipeline in which machine learning techniques are used to automatically identify and evaluate subtypes of hospital patients admitted between 2017 2021 large UK teaching hospital. Patient clusters determined using routinely collected data, such as those the UK’s National Early Warning Score 2 (NEWS2). An iterative, hierarchical clustering process was minimum set relevant features for cluster separation. With use state-of-the-art explainability techniques, identified interpreted...
Abstract Background Mefloquine and artesunate combination therapy is the recommended first-line treatment for uncomplicated malaria throughout much of south-east Asia. Concerns have been raised about potential central nervous system (CNS) effects both drug components there are no detailed reports in very young children. Methods Children, aged between three months five years, with acute Plasmodium falciparum were randomized to either 7 days monotherapy or same schedule plus mefloquine on day...
<ns3:p>Torpor is a hypothermic, hypoactive, hypometabolic state entered into by wide range of animals in response to environmental challenge. This review summarises the current understanding torpor. We start describing characteristics wide-ranging physiological adaptations associated with Next follows discussion thermoregulation, control food intake and energy expenditure, interactions sleep particular emphasis on how those processes pertain move take critical view evidence for systems that...
<ns3:p>Torpor is a hypothermic, hypoactive, hypometabolic state entered into by wide range of animals in response to environmental challenge. This review summarises the current understanding torpor. We start describing characteristics wide-ranging physiological adaptations associated with Next follows discussion thermoregulation, control food intake and energy expenditure, interactions sleep particular emphasis on how those processes pertain move evidence for systems that torpor entry,...
ABSTRACT Introduction Over half of patients who spend >48 hours in the intensive care unit (ICU) are fed via a nasogastric (NG) tube. Current guidance recommends continuous delivery feed throughout day and night. Emerging evidence from healthy human studies shows that NG feeding an intermittent pattern (rather than continuous) promotes phasic hormonal, digestive metabolic responses important for effective nutrition. It is not yet known whether this will translate to critically ill...
Abstract Introduction Torpor is a hypothermic, bradycardic, hypometabolic state enabling animals, such as mice, to survive in unfavourable environmental conditions cold exposure or reduced food availability. It thought be cardioprotective state. There interest developing models that mimic aspects of torpor clinical settings ischaemia-reperfusion injury. The preoptic area the hypothalamus (POA) has emerged key centre for triggering mouse. Purpose Induce synthetic torpor-like species does not...
Abstract The dorsal vagal complex (DVC) is a multi-component brainstem satiety centre which has gained attention as key target of anti-obesity pharmacotherapies. Our recent studies revealed its circadian timekeeping properties, with molecular and electrophysiological 24h rhythms persisting independently the primary hypothalamic clock. However, factors entraining these oscillators, downstream transcriptional targets DVC clock remain unclear. Here, using fluorescent in situ hybridisation, we...
Abstract Torpor is a naturally occurring, hypometabolic, hypothermic state engaged by wide range of animals in response to imbalance between the supply and demand for nutrients. Recent work has identified some key neuronal populations involved daily torpor induction mice, particular projections from preoptic area hypothalamus (POA) dorsomedial (DMH). The DMH plays role thermoregulation, control energy expenditure, circadian rhythms, making it well positioned contribute expression torpor. We...