Background It is essential to embed patient and public perspectives into every stage of the research journey, including setting future agenda. The substantial gaps in our understanding prematurity-associated lung disease presented a timely opportunity determine community’s priorities. Objective To conduct priority partnership (PSP) top 10 priorities for preterm health. Design We undertook modified James Lind Alliance methodology comprising three main stages: (1) an idea generating survey...

The respiratory outcomes for adult survivors of preterm birth in the postsurfactant era are wide-ranging with prognostic factors, especially those encountered after neonatal period, poorly understood.

There is a growing body of research on the association between ambient air pollution and adverse birth outcomes. However, people in high income countries spend most their time indoors. Pregnant women much that at home. The aim this study was to investigate if indoor pollutants were associated with poor recruited prior 18 weeks gestation. They completed housing questionnaire household chemical use survey. Indoor pollutants, formaldehyde (HCHO), nitrogen dioxide (NO2) volatile organic...

Abstract Introduction The European Respiratory Society Oscillometry Taskforce identified that clinical correlates of bronchodilator responses are needed to advance oscillometry in practice. understanding bronchodilator‐induced changes preterm lung disease is poor. Here we describe a comparison assessments performed using and spirometry population born very explore the relationship between respiratory function outcomes. Methods Participants aged 6–23 ≤32 ( N = 288; 132 with bronchopulmonary...

Inflammation and oxidative stress play a key role in the development of bronchopulmonary dysplasia (BPD), possibly contributing to persistent respiratory morbidity after preterm birth. We aimed assess if inflammatory markers were elevated exhaled breath condensate (EBC) infants born very prematurely (< 32 weeks gestation) at 12-16 corrected months age, increased levels associated with BPD diagnosis morbidity.EBC samples questionnaires collected from 15 term-born 33 preterm-born infants, 12...

Preterm birth and subsequent neonatal ventilatory treatment disrupts development of the hypoxic response (HVR). An attenuated HVR has been identified in preterm neonates, however it is unknown whether attenuation persists into second year life. We investigated at 12-15 months corrected postnatal age assessed predictors a blunted those born very (<32 weeks gestation).HVR was measured infants preterm. Hypoxia induced with three-step reduction their fraction inspired oxygen (FIO2) from 0.21 to...

<b>Nasal epithelial</b><b>cells from very preterm infants have a functional defect in their ability to repair beyond the first year of life, and failed may be associated with antenatal steroid exposure</b>https://bit.ly/39OFJs7

Survivors of very preterm birth (<32 weeks gestation) experience lung health deficits that may be progressive over time [1]. Respiratory symptoms are frequently diagnosed as asthma in this population with studies reporting children born (<37 up to 5 times more at risk developing wheezing disorders than their term-born counterparts [2], and 50% by mid-childhood [3]. Contrary the childhood paradigm, patient is typically non-atopic [4] low fractional exhaled nitric oxide (FeNO) [5]....

<title>Extract</title> We have previously reported a reduced epithelial repair capacity in infant survivors of preterm birth [1]. However, it is not known if this defect persists beyond infancy, or whether has any correlation to respiratory function. Given the persistent and progressive lung disease after [2], finding delayed we hypothesised that dysregulated remains feature preterm-associated across life-course an underlying driver pathogenesis. This pilot study specifically tested evident...

&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; Right shift of the peripheral oxyhaemoglobin saturation (SpO&lt;sub&gt;2&lt;/sub&gt;) versus inspired oxygen pressure (P&lt;sub&gt;I&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt;) curve is a sensitive marker pulmonary gas exchange. &lt;b&gt;&lt;i&gt;Objectives:&lt;/i&gt;&lt;/b&gt; The aim this study was to assess impact prematurity and bronchopulmonary dysplasia (BPD) on exchange right-to-left shunt in neonatal period, its evolution over first year...

<b>Introduction:</b> Babies born preterm have altered control of breathing and a blunted hypoxic ventilatory response (HVR) in early postnatal life. We aimed to assess the HVR at 12-15 months corrected age (PNA) determine any lasting effects neonatal exposures on HVR. <b>Methods:</b> The was evaluated infants &lt;32 weeks gestation. Inspiratory time (Ti), expiratory (Te), tidal volume (V_T), respiratory frequency (<i>f</i>), minute ventilation (V_E), drive...

Introduction: The European Respiratory Society Oscillometry Taskforce identified that clinical correlates of bronchodilator responses are needed to advance oscillometry in practice. understanding bronchodilator-induced changes preterm lung disease is poor. Here we describe a comparison assessments performed using and spirometry population born very explore the relationship between respiratory function outcomes. Methods: Participants aged 6-23 ≤32 (N=288; 132 with bronchopulmonary dysplasia)...

<b>Introduction:</b> It is essential to embed consumer perspectives into the research journey, including&nbsp;setting future agenda.&nbsp;Priority Setting Partnerships (PSP) are a well-established involvement tool. We aimed determine consumers9 9Top 109 priorities for preterm lung health by conducting PSP. <b>Methods:</b> Our PSP methodology consisted of 4 main stages: <b>1.</b><i>Idea Generating</i> survey, asking respondents 3 open ended questions ascertain their most important research....

<b>Introduction:</b> Chronic respiratory symptoms in survivors of preterm birth may be underpinned by active pulmonary inflammation, however limited evidence exists to support this theory. Our study aimed assess if inflammatory biomarkers were correlated lung function those born very (&lt;32 weeks GA). <b>Methods:</b> Exhaled breath condensate (EBC), urine samples and spirometry data collected from children young adults during a scheduled research visit. Concentrations for inflammation...

<b>Introduction:</b> Structural lung abnormalities (SLA) are common in children born very preterm (&lt;32 weeks' gestation). However there no longitudinal imaging studies to assess progression or resolution of SLA over time this group. We report childhood and young-adulthood, as well neonatal risk factors for time. <b>Methods:</b> Very (n=133; 10.9±0.6yrs, FEV₁ z-score -0.72±1.13; BPD n=83) young adults (n=125; 19.4-years ±1.3; -0.87±1.16; n=79) 1993-2003 underwent chest CT-scans....

<b>Introduction:</b> Clinical labels, such as bronchopulmonary dysplasia (BPD), assigned in the neonatal ICU are imperfect predictors of reduced peak lung function or early-onset adult respiratory disease. We aimed to define potential trajectories (i.e. persistently low declining) and establish which early life factors associated with specific for those born preterm <b>Methods:</b> 200 very (≤32 weeks gestation), 126 BPD 67 term-born participants attended 629 research visits between age 4 23...

<b>Introduction:</b> Airway epithelial cells (AECs) line the airway to create a protective barrier between lung and external environment. Very preterm birth (&lt;32 weeks gestation) not only disrupts normal development of epithelium, but exposes it potentially injurious treatments required for sustaining life. The current study aimed assess ability epithelium recover from this trauma by characterising repair mechanisms AECs in infants. <b>Methods:</b> Nasal brushings were used collect...