A5061502256- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Congenital Diaphragmatic Hernia Studies
- Infant Development and Preterm Care
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neuroscience of respiration and sleep
- Phonocardiography and Auscultation Techniques
- Injury Epidemiology and Prevention
- Delphi Technique in Research
- Travel-related health issues
Curtin University
2018-2024
The Kids Research Institute Australia
2016-2024
Princess Margaret Hospital for Children
2022-2024
Perth Children's Hospital
2022-2024
Abstract Introduction The European Respiratory Society Oscillometry Taskforce identified that clinical correlates of bronchodilator responses are needed to advance oscillometry in practice. understanding bronchodilator‐induced changes preterm lung disease is poor. Here we describe a comparison assessments performed using and spirometry population born very explore the relationship between respiratory function outcomes. Methods Participants aged 6–23 ≤32 ( N = 288; 132 with bronchopulmonary...
Inflammation and oxidative stress play a key role in the development of bronchopulmonary dysplasia (BPD), possibly contributing to persistent respiratory morbidity after preterm birth. We aimed assess if inflammatory markers were elevated exhaled breath condensate (EBC) infants born very prematurely (< 32 weeks gestation) at 12-16 corrected months age, increased levels associated with BPD diagnosis morbidity.EBC samples questionnaires collected from 15 term-born 33 preterm-born infants, 12...
Survivors of very preterm birth (<32 weeks gestation) experience lung health deficits that may be progressive over time [1]. Respiratory symptoms are frequently diagnosed as asthma in this population with studies reporting children born (<37 up to 5 times more at risk developing wheezing disorders than their term-born counterparts [2], and 50% by mid-childhood [3]. Contrary the childhood paradigm, patient is typically non-atopic [4] low fractional exhaled nitric oxide (FeNO) [5]....
Hypoxia Challenge test (HCT) is the gold standard to predict need for supplemental O<sub>2</sub> during air travel. HCT has been validated in adults and older children but may not be suitable infants born preterm. <b>Aim:</b> To investigate agreement between inflight hypoxia preterm <b>Method:</b> Preterm (<35 wk GA) aged 1-12m attended prior Inflight, had SpO<sub>2</sub> recorded used if <85%. Post flight, oximeter data was analysed nadir. The assessed with intra-class correlations...
<b>Background and Aim:</b> Pulmonary inflammation oxidative stress contribute to the pathogenesis of bronchopulmonary dysplasia (BPD) following preterm birth. We aimed measure non-invasively, using exhaled breath condensate (EBC), in neonates with without BPD. also determine if markers were present later infancy relate biomarker levels disease severity. <b>Methods:</b> EBC was collected from very infants (GA < 32 weeks (w)) BPD at 36 w postmenstrual age (PMA) 12-15 months corrected....
Background: Despite the significant burden of lung disease in children surviving very preterm birth, there are currently no evidence-based interventions to improve their health. We tested hypothesis that inhaled corticosteroids (ICS) function this population. Further, we aimed determine predictors a positive response ICS therapy.Methods: undertook randomised, double-blind, placebo-controlled trial whether ICS, fluticasone propionate, improves childhood survivors birth (6 12 years). randomly...
Introduction: The European Respiratory Society Oscillometry Taskforce identified that clinical correlates of bronchodilator responses are needed to advance oscillometry in practice. understanding bronchodilator-induced changes preterm lung disease is poor. Here we describe a comparison assessments performed using and spirometry population born very explore the relationship between respiratory function outcomes. Methods: Participants aged 6-23 ≤32 (N=288; 132 with bronchopulmonary dysplasia)...
<b>Introduction:</b> Ongoing respiratory symptoms throughout childhood is often diagnosed as asthma in preterm children. Whether prematurity-associated lung disease (PALD) actually subject to intense debate. The recent ERS clinical practice guidelines for the diagnosis of children aged 5–16 years (Gaillard et al. ERJ 2022) advocates use two positive, evidence-based tests confirm asthma. We used 2022 determine rates born very-preterm (≤32 weeks gestation). <b>Methods:</b> Preterm (N=128;...
<b>Introduction:</b> Chronic respiratory symptoms in survivors of preterm birth may be underpinned by active pulmonary inflammation, however limited evidence exists to support this theory. Our study aimed assess if inflammatory biomarkers were correlated lung function those born very (<32 weeks GA). <b>Methods:</b> Exhaled breath condensate (EBC), urine samples and spirometry data collected from children young adults during a scheduled research visit. Concentrations for inflammation...
Intra-breath oscillometry has been proposed as a more sensitive measure of airway obstruction and respiratory mechanics compared to conventional spectral outcomes in children with recurrent wheeze. It is unknown whether intra-breath detects born preterm. We aimed assess measures preterm term-born children. <b>Methods:</b> Spectral was measured using the tremoflo device (Thorasys Inc. Montreal, QC) before after 400 µg salbutamol very (<32 weeks gestation) at term (>37 gestation); aged...