A5012069792- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Neonatal and fetal brain pathology
- Neuroscience of respiration and sleep
- Infant Nutrition and Health
- Maternal and Perinatal Health Interventions
- Infant Health and Development
- Assisted Reproductive Technology and Twin Pregnancy
- Injury Epidemiology and Prevention
- Emergency and Acute Care Studies
- Congenital Diaphragmatic Hernia Studies
- Birth, Development, and Health
- Breastfeeding Practices and Influences
- Retinal Imaging and Analysis
- Family and Patient Care in Intensive Care Units
- Airway Management and Intubation Techniques
- Retinal and Optic Conditions
- Retinal Diseases and Treatments
- Travel-related health issues
- Maternal Mental Health During Pregnancy and Postpartum
- Family and Disability Support Research
- Preterm Birth and Chorioamnionitis
- T-cell and B-cell Immunology
- Congenital Anomalies and Fetal Surgery
- Pregnancy and preeclampsia studies
King Edward Memorial Hospital
2016-2025
Children's Hospital of Oklahoma
2025
The University of Western Australia
2015-2024
Perth Children's Hospital
2020-2024
Princess Margaret Hospital for Children
1998-2024
Government of Western Australia
2020-2024
Government of Western Australia Department of Health
2014-2023
The Kids Research Institute Australia
2002-2022
Memorial Hospital
2022
Edward Hospital
2022
ABSTRACT Increasing evidence indicates that the capacity to induce protective Th1 immune responses is impaired in early childhood, an observation can be partially attributed deficiencies antigen-presenting-cell function. Synthesis of interleukin 12 (IL-12), a key Th1-trophic cytokine, markedly reduced neonatal period, though there paucity knowledge concerning ontogeny IL-12-synthetic throughout childhood years. Hence, we examined production bioactive IL-12 p70 by circulating mononuclear...
To explore the experiences of parents with babies born between 28-32 weeks' gestation during transition through neonatal intensive care unit and discharge to home.Following birth a preterm baby, undergo momentous journey prior their arrival home. The complexity varies on degree prematurity problems faced by each baby. environment has many stressors facilitating education assist feel ready for can be challenging all health professionals.Qualitative descriptive design.The project included two...
Abstract A number of laboratories have reported cord blood T cell responses to ubiquitous environmental Ags, including allergens, by proliferation and cytokine secretion. Moreover, the magnitude these has been linked with risk for subsequent expression allergy. These findings widely interpreted as evidence transplacental priming development fetal memory cells against Ags present in maternal environment. However, we below that suggest neonatal allergens (and other Ags) differ markedly from...
<b><i>Background:</i></b> Early-onset sepsis (EOS) is a potentially fatal condition that affects about 0.3–0.8/1,000 infants born at ≥35 weeks’ gestation in developed countries. Current EOS management algorithms result 8–15% of receiving antibiotics for suspected sepsis. The Neonatal Sepsis Calculator provides evidence-based estimates individual risk, but data on its clinical application limited. <b><i>Objectives:</i></b> To evaluate the...
Docosahexaenoic acid (DHA) is a component of neural tissue. Because its accretion into the brain greatest during final trimester pregnancy, infants born before 29 weeks' gestation do not receive normal supply DHA. The effect this deficiency on subsequent cognitive development well understood.
The purpose of this quality improvement project was to implement and evaluate an algorithm for management prevention diaper dermatitis (DD) embedded in a scoring tool. specific aim the decrease DD occurrences with severity score 3 4 by 25%. Quality participants comprised 164 neonates; 89 were cared prior implementation 75 post-implementation. Data collected over 3-month period. setting 98-bed, Level IV neonatal intensive care unit (NICU) located Midwestern United States (Oklahoma City, OK)....
Introduction Around the world, rates of induction labour (IOL) among nulliparous mothers have increased in last 10 years. In Australia, over decade by 43%, from 32% to 46%. There is growing concern about rapid rise IOL before 41 weeks for women without medical complications because associated caesarean section, reduced satisfaction with birth, and birth trauma. Melatonin potentiates action oxytocin may promote spontaneous onset labour; therefore, we will test hypothesis that exogenous...
The management of births at borderline viability continues to present dilemmas for health professionals and parents. aim the study was review local outcomes infants born between 22 24 weeks gestation 2004 2010 in Western Australia (WA) aid perinatal counselling.Survival data were sourced retrospectively from Neonatal Clinical Care Unit Department Health records WA. Neurodevelopmental follow-up assessed using most recent standardised assessment (Griffiths, Bayley-III Wechsler Preschool...
To compare unintended events in transfers performed by neonatal specialist (NS) and non-neonatal (NNS) teams Western Australia (WA). Retrospective comparison of from the Kimberley Pilbara regions (WA) to tertiary services, King Edward Memorial (perinatal) Perth Children's Hospital Neonatal Intensive Care Unit, (state capital, distance up 2200 km) between January 2018 June 2021. NS traveled referring center back. NNS center. Transport time, team composition, total clinical endotracheal tube...
<h3>Importance</h3> The follow-up schedule for individuals with eyes treated anti–vascular endothelial growth factor agents proliferative diabetic retinopathy (PDR) requires that patients return frequently monitoring and repeated treatment. likelihood a patient will comply should be consideration in choosing treatment approach. <h3>Objective</h3> To describe completion of scheduled examinations among participants assigned to intravitreous injections ranibizumab PDR multicenter randomized...
Population-based retrospective review of gastroschisis from 1986 to 1996.This was a gastroschisis. Seventy cases were identified the Birth Defects Registry Western Australia (WA). Hospital medical records live-born reviewed.The incidence in WA 2.1 per 10,000 live births for period 1986-96. The mothers aged less than 20 years 8.3-fold that women over 30 (P < 0.0001). rate 1995-96 twice 1986-88. Age at first enteral feed significantly related with length hospital stay and duration total...
Introduction Approximately 10–15% of term babies may require admission to neonatal special care units. This level is frequently an unexpected event for parents. Aims To review the frequency and obstetric risk factors associated with neonates a tertiary hospital unit ( SCN ). Materials Methods All born ≥37‐weeks gestation admitted at K ing E dward M emorial H ospital between 2004 2006 were identified from institutional maternity databases. Maternal reviewed identify potential predictors ....
Aim The aim of this study was to highlight the incidence unplanned extubation (UE) and identify associated factors in our neonatal population. Methods This a prospective audit. Results A specifically designed audit tool used capture UE events; 182 neonates required mechanical ventilation for 863 days. There were 41 episodes UE. rate 4.75 per 100 days ventilation. At time UE, median gestational age patients 27.3 weeks (23.4–37.6), with corrected 29.2 (23.4–37.6). Re‐intubation two thirds...
Importance High-dose omega-3 docosahexaenoic acid (DHA) supplementation of children born at less than 29 weeks’ gestation has been shown to improve IQ despite increasing the risk bronchopulmonary dysplasia (BPD). Given that BPD is associated with poorer cognitive outcomes, it unclear whether increased DHA decreased benefit IQ. Objective To investigate was diminished benefit. Design, Setting, and Participants This cohort study used data collected from a multicenter, blinded, randomized...
Mononuclear cells from children with active atopic dermatitis (AD) have been reported to be hyper-responsive certain microbial stimuli, in particular staphylococcal enterotoxin B (SEB). However, it is not known whether this responsiveness acquired during disease development, or inherent. We investigated question a cohort of at high risk atopy followed prospectively birth age 3 years. asked their cord blood mononuclear cell (CBMC) cytokine responses SEB, an unrelated stimulus purified protein...
Introduction The current diagnostic pathways for cognitive impairment rarely identify babies at risk before 2 years of age. Very early detection and timely targeted intervention has potential to improve outcomes these children support them reach their full life potential. Early Moves aims biomarkers, including general movements (GMs), impairment, allowing within critical developmental windows enable have the best possible start life. Method analysis is a double-masked prospective cohort...
Many countries with a high prevalence of tuberculosis routinely immunize children Bacillus Calmette-Guérin (BCG) at birth or as soon possible thereafter, in accordance the Expanded Programme on Immunisation guidelines.1 This policy has not been altered for human immunodeficiency virus type 1 (HIV-1) infection because vaccine is effective preventing (particularly disseminated forms tuberculosis).2 In addition although frequency BCG-related complications may be slightly higher HIV-1-infected...
The extensive health benefits of breastfeeding preterm infants for both mother and infant have been widely reported. However, establishing maintaining very (VP) remain challenging. aim this study was to examine changes in VP over time.Breastfeeding questionnaires were administered two cohorts parents (<32 weeks) cared at the tertiary perinatal or surgical neonatal unit Western Australia. Of these, 488 included cohort 1 (C1) (births from January 1, 1990 June 30, 1992) 253 2 (C2) (from 2011...
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