A5015593879- Infant Development and Preterm Care
- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Congenital Diaphragmatic Hernia Studies
- Birth, Development, and Health
- Cerebral Palsy and Movement Disorders
- Neuroscience of respiration and sleep
- Advanced Neuroimaging Techniques and Applications
- Maternal Mental Health During Pregnancy and Postpartum
- Advanced MRI Techniques and Applications
- Children's Physical and Motor Development
- Respiratory Support and Mechanisms
- Child and Adolescent Psychosocial and Emotional Development
- Infant Health and Development
- Functional Brain Connectivity Studies
- Infant Nutrition and Health
- Fetal and Pediatric Neurological Disorders
- Congenital Heart Disease Studies
- Epigenetics and DNA Methylation
- Preterm Birth and Chorioamnionitis
- Atomic and Subatomic Physics Research
- Pregnancy and preeclampsia studies
- Child and Adolescent Health
- Obesity, Physical Activity, Diet
- Assisted Reproductive Technology and Twin Pregnancy
The University of Melbourne
2016-2025
Royal Women's Hospital
2016-2025
Murdoch Children's Research Institute
2016-2025
Royal Children's Hospital
2013-2025
Monash University
2024
Infant
2015-2023
Hyundai Mobis (South Korea)
2023
Duffy Engineering and Associates (United States)
2022
Harrison Medical Center
2022
Allen Institute for Brain Science
2021
Moderate and late preterm (MLPT) births comprise most infants. Therefore, long-term developmental concerns in this population potentially have a large public health influence. While there are increasing reports of problems MLPT children, detail is lacking on the precise domains that affected.To compare neurodevelopment social-emotional development between infants term-born control at age 2 years.This investigation was prospective longitudinal cohort study single tertiary hospital....
Gestational age is often used as a proxy for developmental maturity by clinicians and researchers alike. DNA methylation has previously been shown to be associated with accurately estimate chronological in children adults. In the current study, we examine whether cord blood can gestational at birth. We find that estimated from of neonatal spot samples. calculate using 148 CpG sites selected through elastic net regression six training datasets. evaluate predictive accuracy nine testing...
Assisted ventilation for extremely preterm infants (<28 weeks of gestation) has become less invasive, but it is unclear whether such developments in care are associated with improvements short-term or long-term lung function. We compared changes over time the use assisted and oxygen therapy during newborn period function at 8 years age children whose birth was premature.We conducted longitudinal follow-up all survivors who were born Victoria, Australia, three periods - 1991 1992 (225...
Mothers experience heightened depression and anxiety following very preterm (VPT) birth, but how these symptoms evolve during the first months after birth is unknown. Research on psychological adjustment of fathers VPT limited.To describe trajectory predictors distress in parents infants 12 weeks to compare rates with those healthy full-term (FT) shortly at 6 months' postnatal age.Longitudinal, prospective, follow-up cohort study (<30 weeks' gestational age; admitted neonatal intensive care...
Survival of extremely preterm (EP; <28 weeks' gestation) infants has increased over the last 2 decades. Equivalent reductions in developmental morbidity early childhood have not been consistently reported. The aim this study was to determine trends neurodevelopmental outcomes at 8 years age children born EP (22-27 completed past decades.Population-based cohorts all survivors state Victoria, Australia 1991-1992, 1997, and 2005 were recruited birth. At age, general intelligence (IQ), academic...
OBJECTIVE. Extremely preterm birth is associated with adverse neurodevelopmental sequelae. Head circumference has been used as a measure of brain growth. There are limited data relating head to MRI. The purpose this work was establish the relationship between MRI at term-equivalent age and relate outcome 2 years. PATIENTS AND METHODS. Two hundred twenty-seven infants (birth weight &lt;1250 g or &lt;30 weeks’ gestation) were recruited. measured birth, term, years’ corrected age, z...
Although ~50% of very preterm (VP) children have neurodevelopmental impairments, early prediction infants who will experience problems later in life remains a challenge. This study evaluated the predictive value general movements (GM; spontaneous and endogenous movements) at 1 3 months' corrected age for neurodevelopment 2 4 years VP children.At age, born <30 weeks' gestation had GM assessed as normal or abnormal. Motor, cognitive, language development was by using Bayley Scales Infant...
<h3>Objective</h3>To investigate the effects of hypothermia treatment on magnetic resonance imaging (MRI) patterns brain injury in newborns with hypoxic-ischemic encephalopathy compared normothermia, including prognostic utility MRI for death and/or disability at a postnatal age 2 years.<h3>Design</h3>Substudy randomized controlled trial.<h3>Setting</h3>Participating centers Infant Cooling Evaluation trial.<h3>Participants</h3>Trial participants (gestational ≥35 weeks moderate to severe...
Aim Children born very preterm are at risk for impaired motor performance ranging from cerebral palsy (CP) to milder abnormalities, such as developmental coordination disorder. White matter abnormalities (WMA) term have been associated with CP in children; however, little is known about the impact of WMA on range impairments. The aim this study was assess whether were predictive all levels impairments children. Method Two hundred and twenty-seven infants (<30wks gestational age or...
Most babies are born healthy and grow develop normally through childhood. There are, however, clearly identifiable high-risk groups of survivors, such as those preterm or with ill-health, who destined to have higher than expected rates health developmental problems, for whom more structured specialised follow-up programs warranted. This paper presents the results a two-day workshop held in Melbourne, Australia, discuss neonatal populations need why, addition how, programme might be...
Purpose To compare the size of multiple brain structures, maturation in terms both myelination and gyral development, evidence injury between moderate late preterm (MLPT) term-born infants at term-equivalent age. Materials Methods The study was approved by human research ethics committees participating hospitals, informed parental consent obtained for all infants. One hundred ninety-nine MLPT 50 underwent 3-T magnetic resonance (MR) imaging examinations 38–44 weeks corrected gestational T1-...
Using prospective longitudinal data from 198 very preterm and 70 full term children, this study characterised the memory learning abilities of children at 7 years age in both verbal visual domains. The relationship between extent brain abnormalities on neonatal magnetic resonance imaging (MRI) outcomes was also investigated. Neonatal MRI scans were qualitatively assessed for global, white-matter, cortical grey-matter, deep cerebellar abnormalities. Very performed less well measures immediate...
BACKGROUND AND OBJECTIVES: The importance of biological versus social influences on long-term outcomes extremely preterm children is debatable. goal this study was to determine the relative contributions and exposures into adolescence in survivors, hypothesizing that would be more important early, but dominate later. METHODS: included 298 consecutive survivors born at &lt;28 weeks’ gestation or weighing &lt;1000 g Victoria, Australia (during 1991–1992), 262 normal birth weight...
<h3>Background</h3> The evolution of airway obstruction into late adolescence extremely preterm (gestational age <28 weeks) or low-birthweight (birth weight <1000 g) survivors in the era after surfactant was introduced is unclear. <h3>Objective</h3> To compare changes spirometry from 8 to 18 years a geographical cohort with normal birth controls, and determine higher risk groups within cohort. <h3>Methods</h3> Of 297 preterm/low-birthweight born 1991–1992 state Victoria, Australia, 81%...