A5051436217- Infant Development and Preterm Care
- Neonatal Respiratory Health Research
- Infant Nutrition and Health
- Infant Health and Development
- Family and Patient Care in Intensive Care Units
- Neonatal and fetal brain pathology
- Congenital Diaphragmatic Hernia Studies
- Birth, Development, and Health
- Injury Epidemiology and Prevention
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Childhood Cancer Survivors' Quality of Life
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Use and Resistance
- Neonatal and Maternal Infections
- Probiotics and Fermented Foods
- Child and Adolescent Health
- Autopsy Techniques and Outcomes
- Healthcare cost, quality, practices
- Electronic Health Records Systems
- Inhalation and Respiratory Drug Delivery
- Healthcare Systems and Technology
- Healthcare Technology and Patient Monitoring
- Esophageal and GI Pathology
- Airway Management and Intubation Techniques
The University of Melbourne
2018-2025
Louisiana State University Health Sciences Center Shreveport
2025
Royal Children's Hospital
2014-2024
Royal Ottawa Mental Health Centre
2012-2024
Murdoch Children's Research Institute
2020-2024
Royal Women's Hospital
2011-2023
Collaborative Group (United States)
2021
University College Dublin
2014
National Centre for Infectious Diseases
2012
Rotunda Hospital
2007-2011
Survival of extremely preterm (EP; <28 weeks' gestation) infants has increased over the last 2 decades. Equivalent reductions in developmental morbidity early childhood have not been consistently reported. The aim this study was to determine trends neurodevelopmental outcomes at 8 years age children born EP (22-27 completed past decades.Population-based cohorts all survivors state Victoria, Australia 1991-1992, 1997, and 2005 were recruited birth. At age, general intelligence (IQ), academic...
Survival of infants born extremely preterm (EP) (<28 weeks' gestation) has increased since the early 1990s. It is necessary to know whether survival accompanied by neurodevelopmental disability.To examine changes in major (ie, moderate or severe) disability and free at 2 years EP.Four prospective longitudinal cohort studies comprising all EP live births 22 27 gestation from April 1, 2016, March 31, 2017, earlier eras (1991-1992, 1997, 2005), contemporaneous term-born controls state Victoria,...
The functional and psychological outcome of 43 patients with polyarticular juvenile arthritis was assessed in order to evaluate the impact disease on their quality life. Mean duration 19.7 yr (range 10-39 yr), mean age 26.7 18-54 yr) sex ratio 1:3 (male:female). Severe disability present 8% systemic onset, 34% RF negative (Rh-P), 38% positive (Rh+P) 86% extended pauci-articular (ExP) arthritics-this last high percentage due ocular impairment. Rh+P had more hip (100% group) knee prostheses...
Background: Antimicrobials are frequently prescribed to neonates who require hospital care, but the influences on clinical decision-making and practice variation in this process ill-understood. We performed a cross-sectional survey of practitioners prescribe antimicrobials 3 Australian neonatal units. Methods: During two 5-day data capture periods per center, 56 reported their general confidence antimicrobial for neonates. Then, 4 questionnaires evaluated diagnostic certainty 68 courses 11...
Late onset sepsis is a frequent complication of prematurity associated with increased mortality and morbidity. The commensal bacteria the gastrointestinal tract play key role in development healthy immune responses. Healthy term infants acquire these organisms rapidly after birth. However, colonisation preterm adversely affected by delivery mode, antibiotic treatment intensive care environment. Altered microbiota composition may lead to pathogenic bacteria, poor susceptibility infant....
Objectives To (1) compare the neurodevelopmental outcomes at 8 years of age children born extremely preterm (EP) who underwent surgical procedures during course their initial hospital admission with those did not and (2) across eras, from 1991 to 2005. Design Prospective observational cohort studies conducted over three different eras (1991-1992, 1997 2005). Surviving EP children, required intervention primary hospitalisation, were assessed for general intelligence (IQ) neurosensory status...
To determine the impact of one probiotics combination on neurodevelopment very preterm children at 2-5 years corrected gestational age (CA).Follow-up study survivors a double-blinded, placebo-controlled, randomised trial probiotic effects late-onset sepsis in infants that found reduced necrotising enterocolitis.10 tertiary perinatal centres Australia and New Zealand.1099 born <32 weeks' gestation weighing <1500 g.Probiotics (Bifidobacterium infantis, Streptococcus thermophilus...
Objectives It is unclear how newer methods of respiratory support for infants born extremely preterm (EP; 22–27 weeks gestation) have affected in-hospital sequelae. We aimed to determine changes in support, survival and morbidity EP since the early 1990s. Design Prospective longitudinal cohort study. Setting The State Victoria, Australia. Participants All births offered intensive care four discrete eras (1991–1992 (24 months): n=332, 1997 (12 n=190, 2005 n=229, April 2016–March 2017 n=250)....
Objective Infants born extremely preterm (EP, <28 weeks’ gestation) exhibit poorer growth and neurodevelopmental impairment in early childhood compared with their term-born peers. Whether poor persists whether associations of functioning have changed the decades since introduction surfactant are not well described. This study aims to (1) compare from birth 2 years then 8 children EP between three different eras, (2) investigate cognitive, academic, executive motor function at years, if...
Abstract Background Although outcomes for infants born extremely low birthweight (ELBW; <1000 g birthweight) have improved over time, it is important to document survival and morbidity changes following the advent of modern neonatal intensive care in 1990s. Objective To describe trends survival, perinatal neurodevelopment 2 years’ corrected age time across six discrete geographic cohorts ELBW between 1979 2017. Methods Analysis data from population‐based prospective cohort studies all...
Neonatal autopsy rates were in decline internationally at the end of last century. Our objective was to assess current value neonatal providing additional information families and healthcare professionals.We conducted a review autopsies performed tertiary perinatal centre over an 11-year period. Primary outcomes measured annual concordance between clinical diagnoses primary cause death. Secondary clinical, genetic audit examinations. Findings used inform consent process, effect this had on...
Few studies have tracked growth in children born extremely preterm (EP, <28 weeks' gestation) beyond late adolescence. The relationships between parameters (including weight and BMI) through childhood adolescence with later cardiometabolic health, are unclear those EP. We aimed to (i) compare from 2 25 years EP controls; the group (ii) determine associations of health.Prospective state-wide cohort all livebirths Victoria, Australia, 1991-1992 contemporaneous term-born controls. Z-scores for...
Nurse perceptions of developmental care practices have been researched globally for almost 30 years. Yet, there is a lack research exploring this subject in the specialised setting surgical neonatal intensive unit (sNICU). This explores effect education programs on sNICU nurses' care.
Objectives The Gaps in the Congenital Diaphragmatic Hernia (CDH) Journey Priority Setting Partnership (PSP) was developed collaboration with CDH Australia, James Lind Alliance (JLA) and Murdoch Children’s Research Institute to identify research priorities for people CDH, their families healthcare workers Australasia. Design PSP accordance JLA standardised methodology. Australian community institutions caring patients families. Patients survivors, of children born (including bereaved)...
Objective Skin-to-skin care (SSC) has proven psychological benefits; however, the physiological effects are less clearly defined. Regional ventilation patterns during SSC have not previously been reported. This study aimed to compare regional indices and other cardiorespiratory parameters prone with supine position cot-nursing. Design Prospective observational study. Setting Single quaternary neonatal intensive unit in Australia. Patients 20 infants spontaneously breathing (n=17) or on...
To (i) determine the appropriateness of antimicrobial prescribing in neonatal intensive care unit (NICU) and (ii) assess impact a collaborative stewardship (AMS) intervention on practices.The was weekly AMS audit-feedback joint ward round (6-month period) Neonatology Infectious Diseases clinicians tertiary Melbourne, Australia. Antibiotic prescriptions were audited recommendations delivered real time. The proportion implemented used to acceptability intervention.During study period, there 23...
Abstract The placement of an endotracheal tube for children with acute or critical illness is a low-frequency and high-risk procedure, associated high rates first-attempt failure adverse events, including hypoxaemia. To reduce the frequency these provision oxygen to patient during apnoeic phase intubation has been proposed as method prolong time available operator insert tube, prior onset However, there are limited data from randomised controlled trials validate efficacy this technique in...
This paper describes the development and justification of a qualitative methodology aimed at exploring infant's personal experience hospitalisation in neonatal intensive care unit (NICU). We begin by briefly reviewing existing methods for documenting recording infant experiences. These focus on clinical needs predominantly through quantifiable medical outcome data. Research understanding their receiving is lacking. By newborn behaviour, cues, communication strategies we assert as capable...