A5049653164- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Congenital Diaphragmatic Hernia Studies
- Airway Management and Intubation Techniques
- Neuroscience of respiration and sleep
- Cardiac Arrest and Resuscitation
- Electrical and Bioimpedance Tomography
- Ultrasound in Clinical Applications
- Infant Development and Preterm Care
- Non-Invasive Vital Sign Monitoring
- COVID-19 Impact on Reproduction
- Hemodynamic Monitoring and Therapy
- Inhalation and Respiratory Drug Delivery
- Heme Oxygenase-1 and Carbon Monoxide
- Family and Patient Care in Intensive Care Units
- Congenital Heart Disease Studies
- Infection Control and Ventilation
- COVID-19 Clinical Research Studies
- Tracheal and airway disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Thermal Regulation in Medicine
- Neonatal and Maternal Infections
- Respiratory viral infections research
- Neonatal Health and Biochemistry
- Chronic Obstructive Pulmonary Disease (COPD) Research
Murdoch Children's Research Institute
2016-2025
Royal Children's Hospital
2016-2025
The University of Melbourne
2016-2025
Royal Women's Hospital
2012-2022
Royal Ottawa Mental Health Centre
2012-2022
Centre Hospitalier Universitaire de Liège
2021
University Medical Center Groningen
2021
University of Groningen
2021
Victoria University
2018
American Thoracic Society
2015
OBJECTIVES: Age-specific definitions for acute respiratory distress syndrome (ARDS) are available, including a specific definition neonates (the “Montreux definition”). The epidemiology of neonatal ARDS is unknown. objective this study was to describe the epidemiology, clinical course, treatment, and outcomes ARDS. DESIGN: Prospective, international, observational, cohort study. SETTING: Fifteen academic ICUs. PATIENTS: Consecutive sample any gestational age admitted participating sites who...
Rationale: The preterm lung is susceptible to injury during transition air breathing at birth. It remains unclear whether rapid or gradual aeration birth causes less injury.Objectives: To examine the effect of and on: 1) spatiotemporal volume conditions lung; 2) resultant regional injury.Methods: Preterm lambs (125 ± 1 d gestation) were randomized receive: tidal ventilation without an intentional recruitment (no-recruitment maneuver [No-RM]; n = 19); sustained inflation (SI) until full (n...
Rationale: The transition to air breathing at birth is a seminal respiratory event common all humans, but the intrathoracic processes remain poorly understood. Objectives: objectives of this prospective, observational study were describe spatiotemporal gas flow, aeration, and ventilation patterns within lung in term neonates undergoing successful transition. Methods: Electrical impedance tomography was used image volume for every breath until 6 minutes from born by elective cesearean section...
Objectives To compare success and safety of endotracheal tube (ETT) exchanges with primary intubations identify factors associated ETT exchange outcomes. Design Retrospective observational study prospectively collected National Emergency Airway Registry for Neonates data. are the placement a new when one is already in place, whereas do not have pre-existing ETT. The outcome was first-attempt success. Secondary outcomes included number attempts, adverse tracheal intubation-associated events...
To assess the accuracy of measurements end tidal carbon dioxide (CO2) during neonatal transport compared with arterial and transcutaneous measurements.Paired CO2 recordings were taken frequently road 21 ventilated neonates. The first paired values an blood gas. differences between (Paco2), (TcPco2), (Petco2) analysed. Bland-Altman method was used to bias repeatability.Petco2 correlated strongly Paco2 TcPco2. However, Petco2 underestimated at a clinically unacceptable level (mean (SD) 1.1...
Rationale: The importance of applying high-frequency oscillatory ventilation with a high lung volume strategy in infants is well established. Currently, lack reliable methods for assessing limits clinicians' ability to achieve the optimum range.Objectives: To map pressure–volume relationship during infants, determine at what point being applied clinically, and describe between airway pressure, volume, oxygenation.Methods: In 12 partial inflation limb deflation were mapped using quasi-static...
Critically ill neonates and infants might particularly benefit from continuous chest electrical impedance tomography (EIT) monitoring at the bedside. In this study a textile 32-electrode interface for neonatal EIT examination has been developed tested to validate its clinical performance. The objectives were assess ease of use in setting, stability contact electrode-skin possible adverse effects.Thirty preterm (gestational age: 30.3 ± 3.9 week (mean SD), postnatal 13.8 28.2 d, body weight...
Ineffective aeration during the first inflations at birth creates regional and ventilation defects, initiating injurious pathways. This study aimed to compare a sustained inflation or dynamic end-expiratory supported recruitment tidal against without intentional on gas exchange, lung mechanics, spatiotemporal ventilation, injury in preterm lambs. Lambs (127 ± 2 d gestation), instrumented birth, were ventilated for 60 minutes from with either lung-protective positive pressure (control) as per...
BackgroundThe benefits of facilitating breastmilk feeding and close contact between mother neonate (family-centred care; FCC) in the perinatal period are well-established. The aim this study was to determine how delivery FCC practices were impacted for neonates born mothers with SARS-CoV-2 infection during COVID-19 pandemic.MethodsNeonates confirmed pregnancy identified from 'EsPnIC Covid paEdiatric NeonaTal REgistry' (EPICENTRE) multinational cohort 10 March 2020 20 October 2021. EPICENTRE...
Neonatal endotracheal tube (ETT) size recommendations are based on limited evidence. We sought to determine data-driven weight-based ETT sizes for infants undergoing tracheal intubation and compare these with Resuscitation Program (NRP) recommendations.
Objective The James Lind Alliance (JLA) Most Premature Babies Priority Setting Partnership aimed to identify the most important areas for research infants born <25 weeks’ gestation. Design Employing standardised JLA methodology, questions were sought from stakeholders via an online survey. Summary formed and checked against existing evidence, with unanswered compiled into a second shortlisting survey prioritisation by stakeholders. A stakeholder consensus workshop was held determine top...
Objectives: During high-frequency oscillatory ventilation, an understanding of the relationship between lung volume and mechanics may help clinicians better apply ventilation. The objectives this study were: 1) to describe function parameters during mapping deflation limb pressure–volume in infants receiving 2) determine whether these might be useful targeting optimal Design: Observational physiological study. Setting: Tertiary neonatal intensive care unit a pediatric hospital. Patients:...
A sustained first inflation (SI) at birth may aid lung liquid clearance and aeration, but the impact of SI duration relative to volume-response is poorly understood. We compared three strategies: 1) variable defined by attaining volume equilibrium using real-time electrical impedance tomography (EIT; plat ); 2) 30 s beyond (SI long 3) short 30-s 4) positive pressure ventilation without (no-SI) on spatiotemporal aeration (EIT), gas exchange, mechanics, regional early markers injury in preterm...