Joe Brierley
A5031835507- Ethics and Legal Issues in Pediatric Healthcare
- Palliative Care and End-of-Life Issues
- Sepsis Diagnosis and Treatment
- Ethics in medical practice
- Child and Adolescent Health
- Childhood Cancer Survivors' Quality of Life
- Organ Donation and Transplantation
- Respiratory Support and Mechanisms
- Hemodynamic Monitoring and Therapy
- Family and Patient Care in Intensive Care Units
- Neonatal Respiratory Health Research
- Organ Transplantation Techniques and Outcomes
- Grief, Bereavement, and Mental Health
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrest and Resuscitation
- Renal function and acid-base balance
- Ultrasound in Clinical Applications
- Patient Dignity and Privacy
- COVID-19 Clinical Research Studies
- Autopsy Techniques and Outcomes
- Mechanical Circulatory Support Devices
- Intensive Care Unit Cognitive Disorders
- COVID-19 and healthcare impacts
- Medical Malpractice and Liability Issues
- Infant Development and Preterm Care
Great Ormond Street Hospital
2016-2025
University College London
2016-2025
Great Ormond Street Hospital for Children NHS Foundation Trust
2014-2025
Center for Science in the Public Interest (United States)
2025
UCL Biomedical Research Centre
2021-2025
NIHR Great Ormond Street Hospital Biomedical Research Centre
2019-2024
European Academy of Technology and Innovation Assessment
2024
The European Academy of Gynaecological Surgery
2019-2024
Great Ormond Street Hospital Children's Charity
2024
Edinburgh Napier University
2023
In communities with high rates of coronavirus disease 2019, reports have emerged children an unusual syndrome fever and inflammation.
Background: The Institute of Medicine calls for the use clinical guidelines and practice parameters to promote "best practices" improve patient outcomes. Objective: 2007 update 2002 American College Critical Care Clinical Guidelines Hemodynamic Support Neonates Children with Septic Shock. Participants: Society members special interest in neonatal pediatric septic shock were identified from general solicitation at Educational Scientific Symposia (2001–2006). Methods: Pubmed/MEDLINE literature...
Objectives: To develop evidence-based recommendations for clinicians caring children (including infants, school-aged children, and adolescents) with septic shock other sepsis-associated organ dysfunction. Design: A panel of 49 international experts, representing 12 organizations, as well three methodologists public members was convened. Panel assembled at key meetings (for those attending the conference), a stand-alone meeting held all in November 2018. formal conflict-of-interest policy...
Objectives: The American College of Critical Care Medicine provided 2002 and 2007 guidelines for hemodynamic support newborn pediatric septic shock. Provide the 2014 update “Clinical Guidelines Hemodynamic Support Neonates Children with Septic Shock.” Design: Society members were identified from general solicitation at Educational Scientific Symposia (2006–2014). PubMed/Medline/Embase literature (2006–14) was searched by librarian using keywords: sepsis, septicemia, shock, endotoxemia,...
Abstract Background Point-of-care ultrasound (POCUS) is nowadays an essential tool in critical care. Its role seems more important neonates and children where other monitoring techniques may be unavailable. POCUS Working Group of the European Society Paediatric Neonatal Intensive Care (ESPNIC) aimed to provide evidence-based clinical guidelines for use critically ill children. Methods Creation international Euro-American panel paediatric neonatal intensivists expert systematic review...
In April, 2020, clinicians in the UK observed a cluster of children with unexplained inflammation requiring admission to paediatric intensive care units (PICUs). We aimed describe clinical characteristics, course, management, and outcomes patients admitted PICUs this condition, which is now known as inflammatory multisystem syndrome temporally associated SARS-CoV-2 (PIMS-TS).We did multicentre observational study (aged <18 years), between April 1 May 10, fulfilling case definition PIMS-TS...
Much of the common practice in paediatric mechanical ventilation is based on personal experiences and what critical care practitioners have adopted from adult neonatal experience. This presents a barrier to planning interpretation clinical trials use specific targeted interventions. We aim establish European consensus guideline critically children.The Society for Paediatric Neonatal Intensive Care initiated conference international experts provide recommendations using Research...
In Brief Objective: We aimed to evaluate the effect of thoracoscopy in neonates on intraoperative arterial blood gases, compared with open surgery. Background: Congenital diaphragmatic hernia (CDH) and esophageal atresia tracheoesophageal fistula (EA/TEF) can be repaired thoracoscopically, but this may cause hypercapnia acidosis, which are potentially harmful. Methods: This was a pilot randomized controlled trial. The target number 20 (weight > 1.6 kg) were either (5 CDH, 5 EA/TEF) or...
To examine the associations with symptoms of 1) burnout and 2) work-related posttraumatic stress, in adult pediatric intensive care staff, focusing on particular contributions resilience coping strategies.Point prevalence cross-sectional study.Three ICUs four PICUs.Three hundred seventy-seven ICU staff.None.Brief Resilience Scale, abbreviated Maslach Burnout Inventory, Trauma Screening Questionnaire, Hospital Anxiety Depression Scale. Prevalence (defined as high emotional exhaustion or...
OBJECTIVE. Early aggressive resuscitation is accepted best practice for severe pediatric sepsis. Targeting of therapy to individual hemodynamic patterns recommended, but assessment difficult early in the disease process. New technologies enabling earlier shock may inform choices vasoactive drugs fluid-resistant cases. METHODS. This was a prospective observational study 30 children with suspected septic (minimum: 40 mL/kg) admitted PICU tertiary care children's hospital between July 2004 and...
Pediatric severe sepsis remains a significant global health problem without new therapies despite many multicenter clinical trials. We compared children managed with in European and U.S. PICUs to identify geographic variation, which may improve the design of future international studies.We conducted secondary analysis Sepsis PRevalence, OUtcomes, Therapies study. Data about PICU characteristics, patient demographics, therapies, outcomes were compared. Multivariable regression models used...
OBJECTIVES: Bordetella pertussis is a common, underrecognized, and vaccine-preventable cause of critical illness with high mortality in infants worldwide. Patients severe cases present extreme leukocytosis develop refractory hypoxemia pulmonary hypertension that unresponsive to maximal intensive care. This may reflect hyperviscosity syndrome from the raised white blood cell (WBC) count. Case reports suggest improved outcomes exchange transfusion reduce WBC Our objective was quantify possible...
Davis, Alan L. MD, MPH, FAAP, FCCM; Carcillo, Joseph A. MD; Aneja, Rajesh K. Deymann, Andreas J. Lin, John C. Nguyen, Trung Okhuysen-Cawley, Regina S. FAAP; Relvas, Monica MSHA, Rozenfeld, Ranna Skippen, Peter W. MBBS, FRCPC; Stojadinovic, Bonnie DNP, CPNP; Williams, Eric MS, MMM; Yeh, Tim MCCM; Balamuth, Fran Brierley, Joe MA; de Caen, Allan R. Cheifetz, Ira M. Choong, Karen MSc, MB, Bch; Conway, Edward Jr Cornell, Timothy Doctor, Dugas, Marc-Andre MSc; Feldman, Jonathan D. Fitzgerald,...
of Paediatrics and Child Health (RCPCH), first published guidance in relation to research involving children 1980. 1 Prior this time, little clinical involved children.The 1980 initiated a sea change, stating 'research is important', 'should be supported encouraged' which involves child no benefit that (non-therapeutic research) not necessarily either unethical or illegal'.Updated was issued by the RCPCH 2000. 2 Both documents have been cited extensively. THE NEED FOR UPDATINGThere are now...
In 2001, the Surviving Sepsis Campaign (SSC) began to develop evidence-based guidelines and recommendations for resuscitation management of patients with sepsis. With 2016 edition, Society Critical Care Medicine European Intensive recommended a separate task force be dedicated guideline formulation children. The objective "Surviving International Guidelines Management Septic Shock Sepsis-associated Organ Dysfunction in Children" is provide guidance care infants, children, adolescents septic...
Abstract Background Cardiovascular instability is common in critically ill children. There a scarcity of published high-quality studies to develop meaningful evidence-based hemodynamic monitoring guidelines and hence, with the exception management shock, currently there are no for The European Society Paediatric Neonatal Intensive Care (ESPNIC) Dynamics section aimed provide expert consensus recommendations on Methods Creation panel experts cardiovascular assessment review relevant...