A5052621779- Neonatal and Maternal Infections
- Neonatal Respiratory Health Research
- Preterm Birth and Chorioamnionitis
- Sepsis Diagnosis and Treatment
- Infant Nutrition and Health
- Immune Response and Inflammation
- Neonatal and fetal brain pathology
- Antibiotics Pharmacokinetics and Efficacy
- Streptococcal Infections and Treatments
- Pharmaceutical studies and practices
- Clinical Nutrition and Gastroenterology
- Infant Development and Preterm Care
- Coconut Research and Applications
- Pediatric health and respiratory diseases
- Neonatal skin health care
- Delphi Technique in Research
- Congenital Diaphragmatic Hernia Studies
- Respiratory viral infections research
- Global Maternal and Child Health
- Infant Health and Development
- Antimicrobial Resistance in Staphylococcus
- Antimicrobial Peptides and Activities
- Inflammation biomarkers and pathways
- Emergency and Acute Care Studies
- Erythropoietin and Anemia Treatment
The Kids Research Institute Australia
2020-2025
King Edward Memorial Hospital
2016-2025
The University of Western Australia
2016-2025
Office of Adolescent Health
2024
St John of God Subiaco Hospital
2023
Okayama University
2023
Government of Western Australia Department of Health
2020-2022
North Metropolitan Health Service
2022
Murdoch University
2021
Princess Margaret Hospital for Children
2008-2019
Abstract There is a paucity of data on the effect preterm birth immunological composition breast milk throughout different stages lactation. We aimed to characterise effects levels immune factors in during 1st month postpartum, determine whether deficient antimicrobial factors. Colostrum (days 2–5 postpartum), transitional 8–12) and mature 26–30) were collected from mothers extremely (<28 weeks gestation, n 15), very (28–<32 moderately (32–<37 15) term infants (37–41 15). Total...
Background Extremely preterm infants are highly susceptible to bacterial infections but breast milk provides some protection. It is unknown if leukocyte numbers and subsets in differ between term milk. This study serially characterised populations of mothers using multicolour flow cytometry methods for extended differential counts blood. Methods Sixty extremely (<28 weeks gestational age), very (28–31 wk), moderately (32–36 as well (37–41 wk) were recruited. Colostrum (d2–5), transitional...
Appropriate use of antibiotics is life-saving in neonatal early-onset sepsis (EOS), but overuse associated with antimicrobial resistance and long-term adverse outcomes. Large international studies quantifying early-life antibiotic exposure along EOS incidence are needed to provide a basis for future interventions aimed at safely reducing exposure.To compare early postnatal antibiotics, EOS, mortality among different networks high-income countries.This retrospective, cross-sectional study...
SUMMARY The inflammatory response plays a major role in the induction of several neonatal diseases. We hypothesize that an imbalance between pro- and anti-inflammatory is crucial for previously shown enhanced production proinflammatory cytokines term preterm infants during infection. To test this hypothesis, we compared capacity to produce main IL-10 TGF-β infants, adults at different levels synthesis by quantitative real time reverse-transcribed PCR, flow cytometry, as well enzyme-linked...
Summary The functional differentiation of immune cells at early age plays a central role in physiology, e.g. for the sufficient eradication pathogens. However, imbalances effector cell responses may also have an impact pathophysiology childhood diseases such as atopy and autoimmune disorders. As information on infancy is scarce, we conducted observational, cross-sectional study healthy newborns (n = 18), infants young children 54) aged 1–96 months adult controls 19) to assess cytokine mRNA...
Background: Histologic chorioamnionitis (HCA) is implicated in the onset of preterm labor and delivery. Chorioamnionitis a known risk factor for early-onset sepsis may modulate postnatal immunity. Preterm infants are at greatly increased late-onset (LOS), particularly with coagulase-negative staphylococci (CoNS), but impact HCA on LOS unknown. Methods: Eight hundred thirty-eight born &lt;30 weeks gestational age single tertiary center were included. examination placenta extraplacental...
Objective We investigated the levels and antimicrobial activity of proteins peptides (AMPs) in breast milk consumed by preterm infants, whether deficiencies these factors were associated with late-onset neonatal sepsis (LOS), a bacterial infection that frequently occurs infants period. Study design Breast from mothers (≤32 weeks gestation) was collected on days 7 (n = 88) 21 77) postpartum. Concentrations lactoferrin, LL-37, beta-defensins 1 2, alpha-defensin 5 measured enzyme-linked...
<b><i>Background:</i></b> Early-onset sepsis (EOS) is a potentially fatal condition that affects about 0.3–0.8/1,000 infants born at ≥35 weeks’ gestation in developed countries. Current EOS management algorithms result 8–15% of receiving antibiotics for suspected sepsis. The Neonatal Sepsis Calculator provides evidence-based estimates individual risk, but data on its clinical application limited. <b><i>Objectives:</i></b> To evaluate the...
Background Staphylococcus epidermidis (SE) is a nosocomial pathogen that causes catheter-associated bacteremia in the immunocompromised, including those at extremes of age, motivating study host clearance mechanisms. SE-derived soluble components engage TLR2; but additional signaling pathways have also been implicated, and TLR2 can play complex, times detrimental, roles defense against other Staphylococcal spp. The role responses primary blood leukocytes to live SE bacteremia, most common...
ABSTRACT Group B streptococcus (GBS) is an important cause of early- and late-onset sepsis in the newborn. Preterm infants have markedly increased susceptibility worse outcomes, but their immunological responses to GBS are poorly defined. We compared mononuclear cell whole-blood cytokine heat-killed (HKGBS) preterm (gestational age [GA], 26 33 weeks), term infants, healthy adults. investigated kinetics source induced cytokines quantified HKGBS phagocytosis. HKGBS-induced tumor necrosis...