Yan Chen

ORCID: 0000-0003-3559-3646
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Tracheal and airway disorders
  • Neonatal Respiratory Health Research
  • Sarcoma Diagnosis and Treatment
  • Airway Management and Intubation Techniques
  • Gastric Cancer Management and Outcomes
  • Congenital Diaphragmatic Hernia Studies
  • Metastasis and carcinoma case studies
  • Cardiac Arrest and Resuscitation
  • Esophageal and GI Pathology
  • Acute Kidney Injury Research
  • Respiratory Support and Mechanisms
  • Trauma and Emergency Care Studies
  • Digital Radiography and Breast Imaging
  • COVID-19 and healthcare impacts
  • Infant Development and Preterm Care
  • Infection Control and Ventilation
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Tumors and Oncological Cases
  • Connective tissue disorders research
  • Spinal Dysraphism and Malformations
  • Phonocardiography and Auscultation Techniques
  • Musculoskeletal synovial abnormalities and treatments
  • Anesthesia and Sedative Agents
  • Ultrasound in Clinical Applications
  • Infectious Diseases and Tuberculosis

First Affiliated Hospital of GuangXi Medical University
2024-2025

Guangxi Medical University
2023-2025

Chinese University of Hong Kong
2024

University of Hong Kong
2021-2024

Chinese PLA General Hospital
2006-2024

Chongqing Medical and Pharmaceutical College
2022-2023

Binzhou University
2023

Binzhou Medical University
2023

Beijing Children’s Hospital
2023

Capital Medical University
2023

Intrahepatic cholangiocarcinoma (ICC), a type of bile duct cancer, has high mortality rate. Gut microbiota, acid (BA) metabolism, and cytokines have not been characterized in patients with ICC, better noninvasive diagnostic approaches for ICC are essential to be established. Therefore, this study we aimed improve our understanding changes gut BA ICC. We found that the α-diversities β-diversities were highest abundances four genera (Lactobacillus, Actinomyces, Peptostreptococcaceae,...

10.1002/hep.30852 article EN Hepatology 2019-07-12

IntroductionPersistent cough with sputum production is an important clinical trait in chronic obstructive pulmonary disease (COPD). We defined “frequent productive cough” based on 2 questions from the St George's Respiratory Questionnaire (SGRQ) and sought to determine its occurrence associated outcomes patients physician-assigned asthma and/or COPD NOVELTY study.MethodsFrequent was as most or several days/week for past 3 months (scoring ≥3 both SGRQ questions). Relationships baseline...

10.1016/j.rmed.2022.106921 article EN cc-by Respiratory Medicine 2022-06-20
Kristy Robledo William O. Tarnow‐Mordi Ingrid Rieger Preeti K. Suresh Andrew Martin and 95 more Carbo Yeung Alpana Ghadge Helen G. Liley David A Osborn Jonathan Morris Wendy Hague Martin Kluckow Kei Lui Roger F. Soll Melinda Cruz Anthony Keech Adrienne Kirby John Simes Himanshu Popat Shelley Reid Adrienne Gordon Koert de Waal Ian Wright Anne Wright Jane Buchan Michelle Stubbs John P. Newnham Karen Simmer Cherry Young Diane Loh Kenneth Yuh Yen Kok Andy Gill Tobias Strunk Michele Jeffery Yan Chen Scott Morris Sanjay Sinhal Kathryn Cornthwaite Susan P. Walker Andrew M. Watkins Clare L. Collins James Holberton Elizabeth J Noble Arvind Sehgal Emma Yeomans Kristy Elsayed Mohamed E. Abdel‐Latif Margaret Broom Guan Koh Annemarie Lawrence Glenn Gardener Jane Fox David Cartwright Pieter Koorts M. A. Pritchard Lisa McKeown Anne Lainchbury Antonia Shand Joanna Michalowski John Smyth Srinivas Bolisetty Alan Adno Gaksoo Lee Anna Lene Seidler Lisa Askie Katie Groom Deborah A Eaglen Ella C Baker Harshad Patel Natalie Wilkes Joanna Gullam Nicola Austin Dianne E Leishman Phil Weston Nicola White Nadia A Cooper Roland Broadbent Michael L. Stitely Pauline Dawson Walid El‐Naggar Marlene Furlong Tara Hatfield Danièle De Luca Alexandra Benachi Emmanuelle Letamendia-Richard Guillaume Escourrou V. Dell’Orto David G. Sweet Muriel Millar Shilpa Shah Lumaan Sheikh Shabina Ariff Erin Morris Leslie Young Shannon K Evans Michael A. Belfort Kjersti M. Aagaard Mohan Pammi George T. Mandy Manisha Gandhi

10.1016/s2352-4642(21)00373-4 article EN The Lancet Child & Adolescent Health 2021-12-08

Abstract The latent TGF‐β binding proteins (LTBP) ‐1, ‐3, and ‐4 are extracellular that assist in the secretion localization of TGF‐β. null mutation LTBP‐4S mice causes defects differentiation terminal air‐sacs, fragmented elastin, colon carcinomas. We investigated lung development from embryonic day 14.5 (E14.5) to 7 after birth (P7) order determine when elastin organization initiate further examine relation signaling levels air‐sac septation Ltbp4S−/− lungs. found elastogenesis visible as...

10.1002/jcp.21643 article EN Journal of Cellular Physiology 2008-11-18

The purpose of this study was to identify risk factors associated with pressure injury (PI) development in patients undergoing major hepatobiliary surgery requiring general anesthesia.Retrospective medical review and analysis.Medical records from 803 October 2015 2016 were reviewed. setting a 3400-bed military academic center the northeast region China.Demographic variables, comorbid conditions, preoperative Braden Scale for Pressure Sore Risk scores, serum hemoglobin albumin levels, type...

10.1097/won.0000000000000356 article EN Journal of Wound Ostomy and Continence Nursing 2017-09-01

Abstract Objective The present study aimed to evaluate the diagnostic performance and safety of PET/CT-guided percutaneous core bone biopsy compare method conventional CT-guided biopsies diagnose Chinese patients with tumors tumor-like lesions. Methods Data for 97 lesions diagnosed by from February 2013 November 2018 were retrospectively analyzed. included 42 cases in PET/CT group 55 CT alone group. performance, cost complications associated intervention compared between two groups. All...

10.1186/s40644-019-0253-1 article EN cc-by Cancer Imaging 2019-10-29

Abstract Background Endoscopic retrograde cholangiopancreatography (ERCP) has been increasingly used to treat patients with biliary/pancreatic duct obstruction or stricture outside the operating room. Effective and safe sedation techniques are needed because of painful stimuli long duration ERCP procedure.Nalbuphine shown cause less respiratory depression during than similar cases without nalbuphine. This study compared effects propofol-nalbuphine (PN) propofol-fentanyl (PF) in undergoing...

10.1186/s12871-022-01578-9 article EN cc-by BMC Anesthesiology 2022-02-16

Introduction Benign airway stenosis (BAS), namely narrowing caused by a variety of benign lesions, can lead to varying degrees breathing difficulties and even death due asphyxia. This study aimed elucidate the clinical characteristics BAS, including etiology, treatment pathology, analyzing data BAS patients. Methods A retrospective analysis was conducted using 617 cases from January 2017 December 2022. The pathological tissues were assessed hematoxylin–eosin (H&E) Masson’s staining....

10.3389/fmed.2023.1202309 article EN cc-by Frontiers in Medicine 2023-07-20

Tracheobronchial stenosis, particularly central airway which frequently results in severe complications such as lung damage, occurs patients with tracheobronchial tuberculosis (TBTB).To analyze the clinical characteristics of stenosis due to (CASTB).Retrospective analysis was performed on features, radiological bronchoscopic features and treatment 157 who were diagnosed CASTB two tertiary hospitals Chongqing, China, from May 2020 2022.CASTB mostly young females. Patients exhibited different...

10.3389/fpubh.2023.1115177 article EN cc-by Frontiers in Public Health 2023-02-02

Since antiquity, Zingiber officinale (ginger), pogostemonis herba, and radix aucklandiae have been used as traditional Chinese medicines to remit gastrointestinal discomfort. Recent evidences also show the efficacy of three herbal against nausea vomiting.To optimize CO2 supercritical fluid extraction (SFE-CO2) conditions for ginger ethanol reflux aucklandiae, control quality herba essential oil, evaluate anti-motion sickness activity compound recipes composed medicine extracts.Two orthogonal...

10.4103/0973-1296.160444 article EN Pharmacognosy Magazine 2015-01-01

A systemic and local inflammatory immune imbalance is thought to be the cause of traumatic tracheal stenosis (TS). However, with CD4

10.1002/iid3.916 article EN cc-by Immunity Inflammation and Disease 2023-08-01

Bronchoscopy is the main method for diagnosis of tracheobronchial tuberculosis (TBTB). However, it not well-used in patients with pulmonary (PTB), leading to misdiagnosis. The aim this study verify value and feasibility bronchoscopy an early treatment TBTB. A prospective observational was performed active PTB. ratios TBTB stenosis were analyzed propensity score matching (PSM) baseline characteristics, a Cox regression model further employed adjust residual confounding factors. total 656 PTB...

10.3389/fmed.2022.825736 article EN cc-by Frontiers in Medicine 2022-02-15

Objective The anatomy of the tracheobronchial tree differs among not only various races but also individual ethnic groups. Different lengths right mainstem bronchus (RMSB) had been described in previous publications. Since differences RMSB and upper lobe (RUB) may have clinical relevance when selecting devices, specifically, right-side double lumen tube (R-DLT) for lung isolation, we revisited a large scale Chinese population. Methods In this retrospective cohort study, reviewed 2093...

10.1371/journal.pone.0242178 article EN cc-by PLoS ONE 2020-11-25

South Africa was the first country with a case of Omicron variant infection diagnosed; therefore, this study aimed to elucidate impact mutant strain outbreak on health behavior African population and encourage adopt timely protective behaviors against infection.This population-based, cross-sectional conducted in Cape Town, Africa, December 2021. We distributed 300 questionnaires adults aged >18 years, they were all returned.Of population, 60.3% expressed high level concern regarding Omicron;...

10.1016/j.onehlt.2022.100395 article EN cc-by-nc-nd One Health 2022-05-05

The aim of the present study was to detect DACT1 expression levels in lungs children with asthma, and investigate its role molecular mechanisms regulating inflammatory factors RAW264.7 cells. DACT1, DACT2 DACT3 analyzed biopsy specimens from 10 cases newly diagnosed asthma healthy controls by reverse transcription-quantitative polymerase chain reaction, their confirmed silenced small interfering RNA or enhanced transfection pcDNA-3.1-DACT1 cells, β-catenin factors, interleukin (IL) 5, IL6...

10.3892/etm.2018.5706 article EN Experimental and Therapeutic Medicine 2018-01-05

Introduction: Hemorrhagic shock (HS) is a severe medical emergency. Early diagnosis of HS important for clinical treatment. In this paper, we report flexible material-based heart sound monitoring device which can evaluate the degree through phonocardiogram (PCG) change. Methods: Progressive hemorrhage treatments (H1, H2, and H3 stage) were used in swine to build animal models. The PCG sensor was mounted on chest swine. Routine at same time. Results: This study showed that arterial blood...

10.3390/mi13071027 article EN cc-by Micromachines 2022-06-28
Coming Soon ...