A5100606064- Regulation of Appetite and Obesity
- Estrogen and related hormone effects
- Biochemical Analysis and Sensing Techniques
- Hypothalamic control of reproductive hormones
- Stress Responses and Cortisol
- Neuropeptides and Animal Physiology
- HIV/AIDS oral health manifestations
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Diagnosis and treatment of tuberculosis
- Advanced Battery Materials and Technologies
- Psoriasis: Treatment and Pathogenesis
- Tuberculosis Research and Epidemiology
- Circadian rhythm and melatonin
- Eating Disorders and Behaviors
- Neurobiology and Insect Physiology Research
- Hormonal Regulation and Hypertension
- Advanced battery technologies research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Infectious Diseases and Tuberculosis
- Tracheal and airway disorders
- Receptor Mechanisms and Signaling
- Menopause: Health Impacts and Treatments
- Obsessive-Compulsive Spectrum Disorders
- Facial Rejuvenation and Surgery Techniques
University of California Davis Medical Center
2024-2025
Northwest University
2024
Chongqing Public Health Medical Center
2019-2023
Capital Medical University
2023
The Affiliated Yongchuan Hospital of Chongqing Medical University
2023
Chongqing Medical University
2023
Weifang University
2023
People’s University
2023
The Fifth People’s Hospital of Suzhou
2023
Beijing Chest Hospital
2023
Binge eating afflicts approximately 5% of US adults, though effective treatments are limited. Here, we showed that estrogen replacement substantially suppresses binge-like behavior in ovariectomized female mice. Estrogen-dependent inhibition was blocked mice specifically lacking receptor-α (ERα) serotonin (5-HT) neurons the dorsal raphe nuclei (DRN). Administration a recently developed glucagon-like peptide-1-estrogen (GLP-1-estrogen) conjugate designed to deliver GLP1 receptor-enhanced...
BackgroundNeural networks that regulate binge eating remain to be identified, and effective treatments for are limited.MethodsWe combined neuroanatomic, pharmacologic, electrophysiological, Cre-lox, chemogenetic approaches investigate the functions of 5-hydroxytryptamine (5-HT) 2C receptor (5-HT2CR) expressed by dopamine (DA) neurons in regulation binge-like behavior mice.ResultsWe showed 5-HT stimulates DA neural activity through a 5-HT2CR-mediated mechanism, activation this midbrain...
Estrogen receptor–α (ERα) activity in the brain prevents obesity both males and females. However, ERα-expressing neural populations that regulate body weight remain to be fully elucidated. Here we showed single-minded–1 (SIM1) neurons medial amygdala (MeA) express abundant levels of ERα. Specific deletion gene encoding ERα (Esr1) from SIM1 neurons, which are mostly within MeA, caused hypoactivity male female mice fed with regular chow, increased susceptibility diet-induced (DIO) but not...
Abstract Sexual dimorphism exists in energy balance, but the underlying mechanisms remain unclear. Here we show that female mice have more pro-opiomelanocortin (POMC) neurons arcuate nucleus of hypothalamus than males, and POMC display higher neural activities, compared to male counterparts. Strikingly, deletion transcription factor, TAp63, confers “male-like” diet-induced obesity (DIO) associated with decreased activities; same does not affect mice. Our results indicate TAp63 contributes...
Abstract Hypothalamic neurons expressing the anorectic peptide Pro-opiomelanocortin (Pomc) regulate food intake and body weight. Here, we show that Steroid Receptor Coactivator-1 (SRC-1) interacts with a target of leptin receptor activation, phosphorylated STAT3, to potentiate Pomc transcription. Deletion SRC-1 in mice attenuates their depolarization by leptin, decreases expression increases leading high-fat diet-induced obesity. In humans, fifteen rare heterozygous variants found severely...
Abstract Estrogens act in the ventromedial hypothalamic nucleus (VMH) to regulate body weight homeostasis. However, molecular mechanisms underlying these estrogenic effects are unknown. We show that activation of estrogen receptor-α (ERα) stimulates neural firing VMH neurons expressing ERα and blocked with intracellular application a pharmacological inhibitor phosphatidyl inositol 3-kinase (PI3K). Further, we demonstrated mice genetic inhibition PI3K activity showed sexual dimorphic obese...
Estrogen receptor-α (ERα) expressed by hypothalamic proopiomelanocortin and steroidogenic factor-1 neurons largely mediates the antiobesity effects of estrogens in females. However, critical molecular events that are coupled to ERα mediate estrogenic on energy balance remain unknown. In current study, we demonstrated steroid receptor coactivator-1 (SRC1), a nuclear coactivator, is abundantly both neurons. We further showed central administration an agonist, propyl pyrazole triol, acutely...
Circadian disruption has become a significant factor contributing to the epidemics of obesity and insulin resistance. However, interventions treat metabolic dysfunctions induced by circadian disruptions are limited. The ovarian hormone, estrogen, produces important antiobesity antidiabetic effects in female animals profound on daily behavioral rhythms. Here, we show that mice depleted with endogenous estrogens, jet-lag paradigm visceral fat accumulation systemic resistance, which were...
Estrogens act upon estrogen receptor (ER)α to inhibit feeding and improve glucose homeostasis in female animals. However, the intracellular signals that mediate these estrogenic actions remain unknown. Here, we report anorexigenic effects of estrogens are blunted mice lack ERα specifically proopiomelanocortin (POMC) progenitor neurons. These mutant also develop insulin resistance insensitive glucose-regulatory estrogens. Moreover, showed propyl pyrazole triol (an agonist) stimulates...
Neurons that co-express agouti-related peptide (AgRP) and neuropeptide Y (NPY) are indispensable for normal feeding behavior. Firing activities of AgRP/NPY neurons dynamically regulated by energy status coordinate appropriate behavior to meet nutritional demands. However, intrinsic mechanisms regulate neural during the fed-to-fasted transition not fully understood. We found in satiated mice express high levels small-conductance calcium-activated potassium channel 3 (SK3) inhibited...
Psychological stress contributes to the development of hypertension in humans. The ovarian hormone, estrogen, has been shown prevent stress-induced pressor responses females by unknown mechanisms. Here, we showed that antihypertensive effects estrogen during were blunted female mice lacking receptor-α brain medial amygdala. Deletion amygdala neurons also resulted increased excitability these neurons, associated with elevated ionotropic glutamate receptor expression. We further demonstrated...
Apolipoprotein A-IV (apoA-IV) in the brain potently suppresses food intake. However, mechanisms underlying its anorexigenic effects remain to be identified.We first examined of apoA-IV on cellular activities hypothalamic neurons that co-express agouti-related peptide (AgRP) and neuropeptide Y (NPY) express pro-opiomelanocortin (POMC). We then compared wild-type mice mutant lacking melanocortin 4 receptors (MC4Rs; AgRP POMC gene product). Finally, we expression mouse hypothalamus quantified...
Background and Purpose Most forms of human obesity are characterized by impaired leptin sensitivity and, therefore, the effectiveness anti‐obesity therapy in these leptin‐resistant obese patients is marginal. Hence, development strategies to increase high priority field research. Experimental Approach We first examined effects co‐administration meta‐chlorophenylpiperazine ( mCPP ), an agonist 5‐HT 2C 1B receptors, on energy balance diet‐induced DIO ) mice. further assessed leptin‐induced...
Framingham Heart Study suggests that dysfunction of steroid receptor coactivator-1 may be involved in the development hypertension. However, there is no functional evidence linking to regulation blood pressure. We used immunohistochemistry map expression protein mouse brain, especially regions implicated Steroid was found central amygdala, medial supraoptic nucleus, arcuate ventromedial, dorsomedial, paraventricular hypothalamus, and nucleus solitary tract. To determine effects on...
Tracheobronchial stenosis, particularly central airway which frequently results in severe complications such as lung damage, occurs patients with tracheobronchial tuberculosis (TBTB).To analyze the clinical characteristics of stenosis due to (CASTB).Retrospective analysis was performed on features, radiological bronchoscopic features and treatment 157 who were diagnosed CASTB two tertiary hospitals Chongqing, China, from May 2020 2022.CASTB mostly young females. Patients exhibited different...
To observe the effects of hippocampal Abeta42 deposition on expression inflammatory cytokines and phosphorylated MAPK signal molecules as well intervention AD by total glucosides paeony (TGP).12 week-old female SD rats were stereotactic injected one-time with a fibrillar positioning hippocampus to replicate pathology model interfered TGP. The pathway signaling observed immunohistochemistry (SABC), SABC images analyzed image analysis software.Compared control group, IL-1beta, IL-6 p-p38,...
Abstract Quasi‐layered sodium titanates have been extensively studied as anode materials for sodium‐ion batteries (SIBs) owing to their quasi‐zero‐strain intercalative storage chemistry and high theoretical capacity. However, sluggish sodiation kinetics unstable electrode/electrolyte interface lead rapid capacity decay at low temperatures. Herein, the local electronic structure interlayer spacing of Na 2 Ti O 5 are finely regulated by heteroelement Sn‐doping, oxygen rich vacancies,...
Background: This investigation assessed patient satisfaction with a temporal incision technique using super-high superficial musculoaponeurotic system (SMAS) flap for midface lifting in Chinese cohort. Methods: From July 2019 to 2023, 95 patients underwent lifts via approach at our institution. The extent of SMAS dissection spanned 2 cm above the outer canthus, lower margin zygomatic arch inferiorly, and medially zygomaticus major muscle. involved anchoring elevated deep fascia elevate malar...