A5101566481- Esophageal and GI Pathology
- Diagnosis and treatment of tuberculosis
- Helicobacter pylori-related gastroenterology studies
- Abdominal vascular conditions and treatments
- Soft tissue tumor case studies
- Radiation Dose and Imaging
- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Inflammatory Bowel Disease
- Medical Imaging Techniques and Applications
- Gastroesophageal reflux and treatments
- Colorectal and Anal Carcinomas
- Advanced X-ray and CT Imaging
- Eosinophilic Esophagitis
- Infectious Diseases and Tuberculosis
- Soft tissue tumors and treatment
- Macrophage Migration Inhibitory Factor
- Phagocytosis and Immune Regulation
- Advanced DC-DC Converters
- Acupuncture Treatment Research Studies
- Neuroblastoma Research and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Estrogen and related hormone effects
- Esophageal Cancer Research and Treatment
Wuhan Union Hospital
2009-2025
Huazhong University of Science and Technology
2012-2024
Union Hospital
2012-2024
Philips (Finland)
2023
Union Hospital
2017-2019
Children's Nutrition Research Center at Baylor College of Medicine
2019
Baylor College of Medicine
2014
Ballard Power Systems (United States)
2004
Binge eating afflicts approximately 5% of US adults, though effective treatments are limited. Here, we showed that estrogen replacement substantially suppresses binge-like behavior in ovariectomized female mice. Estrogen-dependent inhibition was blocked mice specifically lacking receptor-α (ERα) serotonin (5-HT) neurons the dorsal raphe nuclei (DRN). Administration a recently developed glucagon-like peptide-1-estrogen (GLP-1-estrogen) conjugate designed to deliver GLP1 receptor-enhanced...
High power boost converter has become the essential part of distributed system that enables energy to be fully utilized in fuel cell powered electric vehicles and stationary systems. This paper presents analysis design a high-power multileg interleaved with digital signal processor (DSP) based controller. A 20-kW was designed coupled inductors allow core-loss reduction high frequency switching minimize component size eliminate losses under discontinuous conducting mode operation. dual-loop...
Abstract Hypothalamic neurons expressing the anorectic peptide Pro-opiomelanocortin (Pomc) regulate food intake and body weight. Here, we show that Steroid Receptor Coactivator-1 (SRC-1) interacts with a target of leptin receptor activation, phosphorylated STAT3, to potentiate Pomc transcription. Deletion SRC-1 in mice attenuates their depolarization by leptin, decreases expression increases leading high-fat diet-induced obesity. In humans, fifteen rare heterozygous variants found severely...
We explored inflammatory bowel disease (IBD) and eosinophilic esophagitis (EoE) coexistence using a global dataset. Investigating their epidemiology, risks, impact, we aimed to enhance the understanding of concurrent diagnoses patient outcomes. A retrospective population-based cohort study was conducted deidentified data from TriNetX database (2011–2022). estimated incidence prevalence EoE in patients with IBD, including both Crohn's (CD) ulcerative colitis (UC), vice versa. Risks select...
Abstract Background Ulcerative colitis (UC), a chronic inflammatory bowel disease, is marked by sustained inflammation and excessive apoptosis of intestinal epithelial cells (IECs). Despite progress in understanding UC pathogenesis, the role activating transcription factors (ATFs) disease progression remains elusive. Here, we profile expression ATF family members (ATF1–ATF8) colonic mucosa patients identify ATF7 as critical regulator mitophagy through its control PTEN-induced kinase 1...
Abstract Background Ulcerative colitis (UC) is marked by excessive apoptosis of colonic epithelial cells, driven intrinsic defects and impaired macrophage efferocytosis. Inefficient clearance apoptotic cells perpetuates inflammation obstructs tissue resolution. NR1D1, a nuclear receptor involved in cellular homeostasis inflammation, has been implicated immune regulation, but its role UC pathogenesis, particularly efferocytosis, remains poorly understood. Methods A clinical cohort 300...
The aim of this study was to retrospectively analyze the clinical, endoscopic, and pathologic features intestinal tuberculosis (TB).The prevalence TB has been increasing in China.The imaging laboratory examination, data 81 cases patients were analyzed.There 48 male 33 female whose age ranged from 17 76 years (mean, 32.4±1.6 y). Fifty-five diagnosed by endoscopic biopsy, 26 postoperative examination. common symptoms chronic right lower abdominal periumbilical pain (87.7%), weight loss...
The secreted form of 78-kDa glucose-regulated protein (sGRP78) has been widely reported for its property in aiding resolution inflammatory. However, little is known on potential the treatment colitis. To investigate expression pattern and functional outcome GRP78 ulcerative colitis, was measured human murine colitis samples. It found that spontaneously to a high level gut, which physiological site immune tolerance. During active phase DSS-induced sGRP78 significantly reduced but rebounded...
To assess the diagnostic value of spectral parameters in differentiating adrenal adenomas from metastases based on dual-layer detector CT (DLSCT).Patients with or who underwent enhanced DLSCT adrenals were enrolled. The values virtual non-contrast images (CTVNC), iodine density (ID) values, and Z-effective (Z-eff) normalized (NID) slopes HU curves (s-SHC), iodine-to-CTVNC ratios tumors measured each phase. Receiver operating characteristic (ROC) used to compare values.Ninety-nine patients...
Background: Nonspecific terminal ileal ulcers are one of the common ulcerative diseases in ileum. However, studies about treatment efficacy scarce. We aimed to investigate mesalazine this disease. Methods: Eighty-two patients with nonspecific who sought outpatient medical Division Gastroenterology, Wuhan Union Hospital, from April 2016 January 2019 were enrolled and randomly divided into two groups. The experimental group took orally, 4.0 g/d, once a day for 3 months. control was followed up...
Objective To evaluate the effects of three methods with oral compound polyethylene glycol electrolyte powder. Methods A total 180 patients scheduled for colonoscopy were prospectively randomized into groups, group A (n=67), B (n=54) and C (n=59), which received 4-L split-dose PEG, 3-L PEG whole-dose respectively. The colon cleansing quality, access time polyp detection evaluated. Results The times 3 groups were(10.07±5.219)min, (10.19±4.903)min (11.05±5.306)min, respectively,...
Abstract Objective To assess the diagnostic value of spectral parameters in differentiating adrenal adenomas from metastases based on dual-layer detector CT (DLSCT). Materials and methods Patients with or who underwent enhanced DLSCT adrenals were enrolled. The values virtual noncontrast images (CT VNC ), iodine density (ID) values, Z-effective (Z-eff) normalized (NID) slopes HU curves (s-SHC), iodine-to-CT ratios tumors measured each phase. Receiver operating characteristic (ROC) used to...
Introduction: Addressing the knowledge gap left by pre-2016 data, our study examined coexistence of inflammatory bowel disease (IBD) and eosinophilic esophagitis (EOE) using an extensive global dataset up to 2022. By investigating epidemiology, risks immune-mediated conditions, implications their coexistence, we aimed offer a comprehensive understanding these concurrent diagnoses impact on patient outcomes. Methods: A retrospective population-based cohort was conducted deidentified data from...
Objective To analyze and explore the clinical features,pathological characters,treatment prognosis of rectum carcinoid.Methods From January 1997 to 2010,69 pathologically diagnosed carcinoid cases were collected from Union Hospital Tongji Medical College,Huazhong University Science Technology other 7 hospitals.The analyzed. Results Of 69 carconid cases,there 36 males 33 females.The average age was (49.3±12.9) years.The common symptom hemotochezia,abdominal pain,constipation,diarrhoea...