A5082861831- Advanced materials and composites
- Hepatitis C virus research
- Immune Response and Inflammation
- Environmental and Agricultural Sciences
- Oral microbiology and periodontitis research
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Neonatal and Maternal Infections
- Landslides and related hazards
- Powder Metallurgy Techniques and Materials
- Immune cells in cancer
- Soil and Unsaturated Flow
- Heat shock proteins research
- Air Quality and Health Impacts
- Hepatitis B Virus Studies
- HIV/AIDS drug development and treatment
- Silicone and Siloxane Chemistry
- Injection Molding Process and Properties
- Soil erosion and sediment transport
- Histone Deacetylase Inhibitors Research
- Phosphorus and nutrient management
- Environmental Changes in China
- Geotechnical Engineering and Soil Mechanics
- Protein Degradation and Inhibitors
- Adsorption and biosorption for pollutant removal
Shandong Agricultural University
2024-2025
Hunan Rare Earth Metal Material Research Institute
2024
Jiangxi University of Science and Technology
2024
Helmholtz Zentrum München
2023-2024
Dermatology Research Center
2024
German Center for Lung Research
2023-2024
Northeast Agricultural University
2010-2023
Universidad del Noreste
2023
PTC Therapeutics (United States)
2007-2023
Sichuan University
2019-2023
ABSTRACT Objective: To compare the diagnostic accuracy between cone-beam computed tomography (CBCT) and periapical radiography for detecting simulated external apical root resorption (EARR) in vitro. Materials Methods: The study sample consisted of 160 single-rooted premolar teeth simulating EARR varying degrees according to four setups: no (intact teeth), mild (cavity 1.0 mm diameter depth on surface), moderate (0.4 mm, 0.8 1.2 1.6 shortening), severe (2.4 2.8 3.2 3.6 shortening). Two...
In dental clinic, unsatisfactory management of the dentin surface after exposure often leads to occurrence hypersensitivity and caries. Current approaches can occlude tubules on relieve hypersensitivity; however, blocked are generally weak in combating daily tooth erosion abrasion. Moreover, cariogenic bacteria, such as Streptococcus mutans, produce biofilm surface, causing caries compromising tubules' sealing efficacy. To overcome this problem, present study focused establishing a versatile...
Targeted drug delivery systems have currently demonstrated considerable potential clinical benefits in cancer treatment. Curcumin has become a candidate anti-tumor for the therapy of glioblastoma multiforme (GBM) by increasing cell apoptosis and suppressing proliferation. In current research, we explored novel targeted system with self-assembly measure curcumin, MPEG-PLA Fa-PEG-PLA. Compared free curcumin Cur/MPEG-PLA, Cur/Fa-PEG-PLA can remarkably suppress growth GL261 cells promote...
Sis1 is an essential yeast Type II Hsp40 protein that assists cytosolic Hsp70 Ssa1 in the facilitation of processes include translation initiation, prevention aggregation, and proteasomal degradation. An function other proteins binding delivery non-native polypeptides to Hsp70. How Hsp40s as molecular chaperones unknown. The crystal structure a fragment retains peptide-binding activity suggests utilize hydrophobic residues located solvent-exposed patch on carboxyl-terminal domain I bind...
A novel, potent, and orally bioavailable inhibitor of hepatitis C RNA replication targeting NS4B, compound 4t (PTC725), has been identified through chemical optimization the 6-(indol-2-yl)pyridine-3-sulfonamide 2 to improve DMPK safety properties. The focus SAR investigations identify optimal combination substituents at indole N-1, C-5, C-6 positions sulfonamide group limit potential for in vivo oxidative metabolism achieve an acceptable pharmacokinetic profile. Compound excellent potency...
Relationship between facial attractiveness and components is not completely clear. The aim was to analyze the correlation assessed by laypersons orthodontists.The of 100 adult patients (50 males 50 females with their frontal, lateral, frontal smiling photos), before orthodontic treatment, 24 orthodontists using visual analog scale. Pearson coefficient stepwise regression were used for statistical analysis.When assessed, a significant found chin (r = 0.671), eyes 0.669), lips 0.585), hair...
<title>Abstract</title> Wheat is one of the earliest domesticated crops and serves as a crucial staple food globally. However, farmland salinization severely restricts wheat production poses significant threat to global security. In this study, <italic>Aegilops tauschii</italic>Y215, exhibiting superior salt tolerance, was selected from panel 91 <italic>Ae. tauschii </italic>lines. A set wheat-<italic>Ae. tauschii</italic> introgression lines developed through cross between variety Jimai22...
Summary Preterm birth ( PTB ), accompanied by low weight LBW ) or not, is a syndrome with tremendous risk factors and long‐term health consequences for children. In recent decades, overwhelming studies have shown that periodontitis contributes to prematurity . This study was conducted determine the link between maternal pathogenesis of and/or through rat infection model induced Porphyromonas gingivalis , an important periodontopathic bacterium. The murine established surgically ligating left...
Abstract Non‐tuberculous mycobacteria (NTM), also known as an environmental and atypical mycobacteria, can cause the chronic pulmonary infectious diseases. Macrophages have been suggested main host cell to initiate innate immune responses NTM infection. However, molecular mechanism regulate antimicrobial is still largely unknown. Current study showed that clinical groups, Mycobacterium abscessus smegmatis, significantly induced M1 macrophage polarization with characteristic production of...
Abstract Nanomaterials emerged as boundless resource of innovation, but their shape and biopersistence related to respiratory toxicology raise longstanding concerns. The development predictive safety tests for inhaled nanomaterials, however, is hampered by limited understanding cell type-specific responses. To advance this knowledge, we used single-cell RNA-sequencing longitudinally analyze cellular perturbations in mice, caused three carbonaceous nanomaterials different toxicity upon...
The o1 model series is trained with large-scale reinforcement learning to reason using chain of thought. These advanced reasoning capabilities provide new avenues for improving the safety and robustness our models. In particular, models can about policies in context when responding potentially unsafe prompts, through deliberative alignment. This leads state-of-the-art performance on certain benchmarks risks such as generating illicit advice, choosing stereotyped responses, succumbing known...