A5072599705- Immune cells in cancer
- Advanced biosensing and bioanalysis techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- Biosensors and Analytical Detection
- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Protein Degradation and Inhibitors
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
- Air Quality and Health Impacts
- Nanoplatforms for cancer theranostics
- Peptidase Inhibition and Analysis
- Ubiquitin and proteasome pathways
- Immunotherapy and Immune Responses
- Phagocytosis and Immune Regulation
- Immune Cell Function and Interaction
- Antimicrobial Peptides and Activities
- MicroRNA in disease regulation
- Microplastics and Plastic Pollution
- Cytomegalovirus and herpesvirus research
- Hybrid Renewable Energy Systems
- Receptor Mechanisms and Signaling
- Advanced Nanomaterials in Catalysis
- Cancer-related molecular mechanisms research
- Redox biology and oxidative stress
Southern University of Science and Technology
2020-2025
Jinan University
2020-2025
ShenZhen People’s Hospital
2022-2024
Shenzhen Bay Laboratory
2024
Shihezi University
2024
Sichuan University
2015-2023
State Key Laboratory of Respiratory Disease
2022
West China Medical Center of Sichuan University
2016-2020
Helmholtz Zentrum München
2014-2017
German Center for Lung Research
2014-2016
A new lateral flow immunoassay strip (LFIA) combining sensitive detection and identification of multiple bacteria remains a huge challenge. In this study, we first developed multifunctional urchin-shaped Au-Ag@Pt nanoparticles (UAA@P NPs) with unique combination colorimetric-SERS-photothermal-catalytic (CM/SERS/PT/CL) properties integrated them LFIA for multiplexed specific discrimination pathogenic in blood samples. Unlike the conventional that relied on antibody (Ab), novel introduced...
Ultra-sensitive detection of cancer-related biomarkers in serum is great significance for early diagnosis, treatment, prognosis, and staging cancer. In this work, we proposed a surface-enhanced Raman scattering fluorescence (SERS/FL) dual-mode biosensor hepatocellular carcinoma (HCC)-related miRNA (miR-224) using the composition well-arranged Au nanoarrays (Au NAs) substrate coupled with target-catalyzed hairpin assembly (CHA) strategy. The hot spots densely uniformly distributed on array...
In situ and real-time monitoring of responsive drug release is critical for the assessment pharmacodynamics in chemotherapy. this study, a novel pH-responsive nanosystem proposed chemo-phototherapy by surface-enhanced Raman spectroscopy (SERS). The Fe3O4@Au@Ag nanoparticles (NPs) deposited graphene oxide (GO) nanocomposites with high SERS activity stability are synthesized labeled reporter 4-mercaptophenylboronic acid (4-MPBA) to form probes (GO-Fe3O4@Au@Ag-MPBA). Furthermore, doxorubicin...
Despite the potential indicating role of tyrosinase (TYR) in cutaneous melanoma, how to capture real changes TYR suspicious skin remains a major challenge. Unlike traditional human serum test, this study reports sensing platform that incorporates wearable microneedle (MN) patch and trimetallic Au@Ag-Pt nanoparticles (NPs) for surface-enhanced Raman scattering (SERS) colorimetric dual-mode detecting situ toward melanoma screening. In presence TYR, catechol immobilized on MN is preferentially...
Defective autophagy is linked to proinflammatory diseases. However, the mechanisms by which limits inflammation remain elusive. Here, we found that pan-FGFR inhibitor LY2874455 efficiently activated and suppressed expression of factors in macrophages stimulated lipopolysaccharide (LPS). Multiplex proteomic profiling identified immunoproteasome, a specific isoform 20s constitutive proteasome, as substrate degraded selective autophagy. SQSTM1/p62 was be autophagy-related receptor mediated this...
Persons with cystic fibrosis (CF) are at-risk for health effects from ambient air pollution but little is known about the interaction of nanoparticles (NP) CF lungs. Here we study distribution inhaled NP in a murine model and aim to reveal mechanisms contributing adverse particles susceptible populations. Chloride channel defective CftrTgH (neoim) Hgu mice were used analyze lung function, whole body biokinetics NP, inflammatory responses after intratracheal administration NP. Distribution...
Carbonaceous nanoparticles (CNP) represent a major constituent of urban particulate air pollution, and inhalation high CNP levels has been described to trigger pro-inflammatory response the lung. While several studies identified specific particle characteristics driving respiratory toxicity low-solubility low-toxicity particles such as CNP, lung cell type, which initiates drives that response, remains still uncertain. Since alveolar macrophages (AM) are known effectively phagocytose inhaled...
Uropathogenic Escherichia coli (UPEC) biofilm formation enables the organism to avoid host immune system, resist antibiotics, and provide a reservoir for persistent infection. Once is established, eradication of infection becomes difficult. Therefore, strategies against UPEC are urgently required. In this study, we investigated effect allicin, isolated from garlic essential oil, on CFT073 J96 dispersal, along with its adhesion ability swimming motility. Sub-inhibitory concentrations...
The exponential increasement and the attributes of medical data drive requirement for secure archiving. DNA storage shows promise storing sensitive important like records due to its high density endurance. Nevertheless, current working scheme generally does not fully consider encryption, posing a risk corruption by routine sequencing. Here, we designed "multi-layer" encryption pipeline Initially, digital information was encrypted using Blowfish algorithm at technology (IT) layer, followed...
Early apoptosis real-time detection by label-free SERS based on externalized phosphatidylserine using<italic>in situ</italic>synthesized silver nanoparticles.
Cellular energy metabolism plays a crucial role in the regulation of macrophage polarization and execution immune functions. A recent study showed that Slc6a8-mediated creatine uptake from exogenous supplementation modulates polarization, yet little is known about de novo biosynthesis pathway polarization. Here, we observed glycine amidinotransferase (GATM), rate-limiting enzyme for synthesis, was upregulated alternative (M2) polarized macrophages, dependent on transcriptional factor STAT6,...
Chronic obstructive pulmonary disease (COPD) is a progressive chronic lung characterized by airway inflammation and emphysema. Macrophage polarization plays an important role in COPD pathogenesis secreting inflammatory mediators. Bromodomain-containing protein 4 (BRD4), epigenetic reader that specifically binds to histones, crucial diseases regulating macrophage polarization. Herein, we attempted examine the hypothesis modulating alveolar via BRD4 inhibitors might has potential for...
Inhalation of environmental (nano) particles (NP) as well persistent herpesvirus-infection are potentially associated with chronic lung disease and both omnipresent in human society a coincidence these two factors is highly likely. We hypothesized that NP-exposure persistently herpesvirus-infected cells second hit might disrupt immune control viral latency, provoke reactivation latent virus eventually lead to an inflammatory response tissue damage. To test this hypothesis, we applied...
Ovarian cancer (OC) typically develops an immunosuppressive microenvironment by funtional changes of host immune cells. Dysregulated m6A level is associated with progression via the intrinsic oncogenic pathways. However, role in regulating cell function during anti-tumor immunity needs comprehensive analysis. This study aimed to investigate METTL3, a catalytic subunit methyltransferase complex, response against OC.In this study, myeloid-specific Mettl3 gene knockout (Mettl3-cKO) mice were...
Abstract Prostate specific antigen (PSA) is widely used in liquid biopsy of prostate cancer (PCa) but still faces challenges due to the poor specificity. Herein, this study reports a double‐SERS satellite immunoassay, made an Au–Ag dealloyed intra‐nanogap nanoflower (Au–Ag DINF) with strong SERS signals and Au magnetic nanoparticles (AuMNPs) capture amplification, for sensing multiple PSA (free (fPSA), complexed (cPSA) [‐2]proPSA (p2PSA)) toward potential PCa screening. Unlike previous...
Abstract Non‐tuberculous mycobacteria (NTM), also known as an environmental and atypical mycobacteria, can cause the chronic pulmonary infectious diseases. Macrophages have been suggested main host cell to initiate innate immune responses NTM infection. However, molecular mechanism regulate antimicrobial is still largely unknown. Current study showed that clinical groups, Mycobacterium abscessus smegmatis, significantly induced M1 macrophage polarization with characteristic production of...