A5081224688- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Neonatal and Maternal Infections
- Neonatal Respiratory Health Research
- Sepsis Diagnosis and Treatment
- Infant Nutrition and Health
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neonatal and fetal brain pathology
- Peptidase Inhibition and Analysis
- Pneumonia and Respiratory Infections
- Monoclonal and Polyclonal Antibodies Research
- Bacterial Genetics and Biotechnology
- Cystic Fibrosis Research Advances
- Oral microbiology and periodontitis research
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Use and Resistance
- Blood disorders and treatments
- Enterobacteriaceae and Cronobacter Research
- Probiotics and Fermented Foods
- Bacteriophages and microbial interactions
- Retinopathy of Prematurity Studies
- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- COVID-19 Impact on Reproduction
- Drug Transport and Resistance Mechanisms
Women & Infants Hospital of Rhode Island
2014-2024
Brown University
2014-2024
University of Rochester Medical Center
1994-2024
Providence College
2006-2023
Wesley Medical Center
2021
John Brown University
2015
Rhode Island Hospital
2014
Warren Alpert Foundation
2014
Baylor College of Medicine
2013
University of Rochester
2001-2004
Very low birth weight infants (VLBW, < or = 1500 g) are at increased risk for invasive disease caused by fungi, and colonization is an important factor. This study was designed to examine the effect of maternal flora on Candida VLBW infants.Body site samples were collected within 24 hours delivery from mothers who gave infants, their birth, then weekly 12 weeks until death discharge. Yeast isolates identified as albicans standard methods typed DNA fingerprinting using a C. strain-specific...
Among extremely preterm infants, we evaluated whether bevacizumab therapy compared with surgery for retinopathy of prematurity (ROP) is associated adverse outcomes in early childhood.
Appropriate use of antibiotics is life-saving in neonatal early-onset sepsis (EOS), but overuse associated with antimicrobial resistance and long-term adverse outcomes. Large international studies quantifying early-life antibiotic exposure along EOS incidence are needed to provide a basis for future interventions aimed at safely reducing exposure.To compare early postnatal antibiotics, EOS, mortality among different networks high-income countries.This retrospective, cross-sectional study...
The in vitro susceptibility of pathogenic Candida species to the photodynamic effects clinically approved photosensitizing agent Photofrin was examined. Internalization by confirmed confocal fluorescence microscopy, and degree uptake dependent on incubation concentration. Uptake subsequent sensitivity irradiation influenced culture conditions. poor C. albicans blastoconidia grown nutrient broth. However, conversion filamentous forms defined tissue medium resulted substantial uptake. Under...
To determine the frequency of respiratory viral infections among infants who were evaluated for late-onset sepsis in neonatal intensive care units (NICUs) Parkland Memorial Hospital, Dallas, Texas; and Women & Infants Providence, Rhode Island. Prospective cohort study conducted from January 15, 2012 to 31, 2013. NICU enrolled if they inborn, had never been discharged home, (at >72 hours age) antibiotic therapy was initiated. a nasopharyngeal specimen collected detection viruses by multiplex...
Recent in vitro studies have implicated galectin-3 as an important receptor host recognition and response to specific Candida species; however, its role protection against disseminated candidiasis vivo has not been evaluated. This study investigated the importance of defense systemic infection with highly virulent species albicans, less species, C. parapsilosis. Mice deficient (gal3-/-) were more susceptible than wild-type (WT) mice. When infected gal3-/- mice died significantly faster...
Abstract Background Early-life antibiotic exposure is disproportionately high compared to the burden of culture-proven early-onset sepsis (CP-EOS). We assessed contribution culture-negative cases overall in first postnatal week. Methods conducted a retrospective analysis across eleven countries Europe, North America, and Australia. All late-preterm term infants born between 2014 2018 who received intravenous antibiotics during week were classified as treated for ≥5 days (CN ≥ 5d), <5 <...
Candida albicans causes the majority of invasive candidiasis in immunocompromised adults while parapsilosis is a leading cause neonatal candidiasis. While much work has focused on how immune system recognizes and responds to C. albicans, less known about host interaction with parapsilosis. This study investigates human neutrophil phagocytic response these species. Neutrophils underwent phagocytosis yeast hyphae more efficiently than yeast. Treatment neutrophils galectin-3 (gal3) blocking...
Administration of high-dose parenteral amino acids (AAs) to premature infants within hours delivery is currently recommended. This study compared the effect lower and higher AA administration starting close birth on short-term growth neurodevelopmental outcomes at 18-24 months corrected gestational age (CGA). Infants <1250 g weight (n = 168) were randomly assigned in a blinded fashion receive nutrition providing 1-2 g/kg/d advancing daily by 0.5 goal 4 (standard AA) or 3-4 day 1. The primary...
Release of neutrophil extracellular traps (NETs) is a significant antimicrobial host defense mechanism in adults. In neonates, fungal sepsis frequent cause morbidity and mortality may be consequence inadequate functions. Like neutrophils from adult donors, we found that neonates formed robust cellular aggregates released NETs response to β-glucan Candida albicans hyphae when presented with matrix. Therefore, stimulation, neonatal are capable NETosis. Neonate susceptibility infections not due...
The tough, hydrogel glue produced by the slug Arion subfuscus achieves impressive performance through metal-based, protein cross-links. primary sequence of these proteins was determined transcriptome sequencing and proteome analysis tandem mass spectrometry. main that correlate with adhesive function are a group 11 small, highly abundant lectin-like proteins. These matched ligand-binding C-lectin, C1q or H-lectin domains. variety different their potential for oligomerization suggests they as...
Candida is an important cause of infections in premature infants. Gastrointestinal colonization with a common site entry for disseminated disease. The objective this study was to determine whether dietary supplement medium-chain triglycerides (MCTs) reduces preterm Preterm infants (n = 12) receiving enteral feedings either infant formula 5) or breast milk 7) were randomized MCT supplementation 8) no 4). Daily stool samples collected fungal burden during 3-week period. Infants the group...