A5049826033- Neonatal Respiratory Health Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Congenital Diaphragmatic Hernia Studies
- Respiratory Support and Mechanisms
- Cystic Fibrosis Research Advances
- Neurogenetic and Muscular Disorders Research
- Infant Development and Preterm Care
- Lysosomal Storage Disorders Research
- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Respiratory viral infections research
- Glycogen Storage Diseases and Myoclonus
- Nausea and vomiting management
- Respiratory and Cough-Related Research
- Social Media in Health Education
- Child and Adolescent Health
- Hemodynamic Monitoring and Therapy
- Restraint-Related Deaths
- Heart Failure Treatment and Management
- Cerebral Palsy and Movement Disorders
- Health Literacy and Information Accessibility
- Congenital Heart Disease Studies
- Noise Effects and Management
Austin Health
2021
The Kids Research Institute Australia
2011-2020
Royal Children's Hospital
2016-2019
The University of Western Australia
2011-2018
Erasmus MC - Sophia Children’s Hospital
2014-2016
Boston Children's Hospital
2015
<h3>Rationale</h3> Survivors of preterm birth are at risk chronic and lifelong pulmonary disease. Follow-up data describing lung structure function scarce in children born during the surfactant era. <h3>Objectives</h3> To obtain comprehensive on mid-childhood from survivors birth. We aimed to explore relationships between structure, respiratory morbidity as well early life contributors poorer childhood outcomes. <h3>Methods</h3> Lung was tested 9–11 years term (controls) ≤32 weeks gestation....
Background In school-aged children with cystic fibrosis (CF) structural lung damage assessed using chest CT is associated abnormal ventilation distribution. The primary objective of this analysis was to determine the relationships between distribution outcomes and presence extent as by in infants young CF. Methods Data CF diagnosed following newborn screening consecutively reviewed August 2005 December 2009 were analysed. Ventilation (lung clearance index first second moment ratios [LCI,...
Pompe disease is a progressive metabolic myopathy. Involvement of respiratory muscles leads to pulmonary dysfunction, particularly in supine position. Diaphragmatic weakness considered be the most important component. Standard spirometry some extent indicative but provides too little insight into diaphragmatic dynamics. We used lung MRI study and chest-wall movements disease.In ten adult patients six volunteers, we acquired two static spirometer-controlled scans during maximum inspiration...
Aim We assessed the feasibility of telehealth spirometry assessments for children with cystic fibrosis (CF) living in a regional setting. Method Patients acceptable computer hardware at home were provided SpiroUSB (Vyaire) spirometer. Spirometry was performed during ‘home admissions’ or ongoing monitoring outside metropolitan Melbourne. At end session, family forwarded data to Royal Children’s Hospital, Results Twenty-two patients aged 7 17 years participated, successful 55 59 (93%)...
Abstract Background Exhaled breath temperature (EBT) has been proposed for the non‐invasive assessment of airway inflammation. Previous studies have not examined influence room or lung size on EBT. Objective This study aimed to address these issues in healthy children. Methods We assessed effects and volume 60 children aged 9–11 years (mean age 10.3 years, 33 male). Static volumes were using multiple nitrogen washout. Questionnaire skin prick tests also used establish respiratory health...
Evidence regarding the prevalence of expiratory flow limitation (EFL) during exercise and ventilatory response to in children born preterm is limited. This study aimed determine EFL as well contributing factors with without bronchopulmonary dysplasia (BPD). Preterm (≤32 weeks gestational age) aged 9–12 years (n=64) (n=42) BPD term controls (n=43), performed an incremental treadmill test tidal flow–volume loops. More (53%) had compared (26%) or (28%) (p<0.05). The presence was...
Severe pulmonary dysfunction is a serious threat to patients with Pompe disease, treatable metabolic neuromuscular disorder caused by lysosomal acid alpha glucosidase defi ciency.This -which particularly severe in the supine position -is mainly diaphragmatic weakness.Standard function tests only provide indirect information about function, and they do not supply chest mechanics detail.We therefore used cine-MRI examine dynamic performance of respiratory muscles, compared these data results...
<b>Background:</b> Children born preterm have a reduced exercise capacity and structural lung disease. <b>Aim:</b> To identify the effect of disease on response in children aged 9-11, who were preterm. <b>Methods:</b> Preterm (<32 w gestational age) performed spirometry, incremental treadmill to volitional exhaustion underwent high resolution CT (HRCT) scan chest. <b>Results:</b> Abnormalities HRCT noted 68/78 (87 %) children. The most common abnormalities linear subpleural triangular...
<b>Introduction:</b> Bronchopulmonary dysplasia (BPD) remains the most significant pulmonary complication of preterm birth. The long term respiratory sequelae children born very are unclear. <b>Aim:</b> To examine how lung function tracks over school years in preterm. <b>Methods:</b> Term controls (N=32) and <32 weeks gestational age (GA) with (+BPD, N=74) without (−BPD, N=44) a neonatal classification BPD performed at 4-7 and/or 9-11 years. Outcomes from spirometry (FEV1, FVC, FEV1/FVC,...
<b>Introduction:</b> Delayed early oxygen uptake (VO2) recovery reflects disease severity in chronic lung or heart disease, linked to delayed of muscle energy stores. No previous studies have investigated this children born very preterm where altered structure may impair <b>Hypothesis:</b> Children a VO2 associated with worse neonatal disease. <b>Methods:</b> (<32w gestational age; GA), and term healthy controls were recruited. performed spirometry maximal treadmill exercise test...