A5047418073- Autoimmune Bullous Skin Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Urticaria and Related Conditions
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Renal Diseases and Glomerulopathies
- Cutaneous lymphoproliferative disorders research
- Cancer-related molecular mechanisms research
- Nanocluster Synthesis and Applications
- Nonmelanoma Skin Cancer Studies
- Radio, Podcasts, and Digital Media
- Autophagy in Disease and Therapy
- Metal-Organic Frameworks: Synthesis and Applications
- Inflammasome and immune disorders
- Phytochemistry and Bioactive Compounds
- CO2 Reduction Techniques and Catalysts
- Computational Drug Discovery Methods
- Dermatology and Skin Diseases
- Human-Animal Interaction Studies
- Lanthanide and Transition Metal Complexes
- Quantum Dots Synthesis And Properties
Peking Union Medical College Hospital
2018-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2025
Shanghai East Hospital
2021-2024
Wuhan University
2017-2024
German Cancer Research Center
2022-2024
Shanghai Changzheng Hospital
2024
Institute of Molecular Functional Materials
2023
Zhengzhou University
2019-2023
Hunan City University
2022
Heidelberg University
2022
Abstract Bullous pemphigoid (BP) is an acquired autoimmune bullous disease that often occurs in elderly patients. Some BP patients with early age of onset were observed to have difficulty receiving applicable control. It remains challenging for clinicians choose the appropriate treatment these This study aimed analyze differences between different ages at and further explore possible mechanism ages. A total 215 seen dermatology department Peking Union Medical College Hospital January 2009...
Background Neural crest-associated genes play pivotal roles in tumor initiation, progression, and the intricate dynamics of microenvironment (TME). Myeloid-derived suppressor cells (MDSC) within TME are important dampening T cell activity contributing to resistance against immunotherapeutic interventions. The neural gene Forkhead Box D1 (FOXD1) has been identified as an oncogenic factor that induces melanoma dedifferentiation progression. However, underlying mechanisms impact FOXD1 on...
Muscle wasting is the key manifestation of cancer-associated cachexia, a lethal metabolic disorder seen in over 50% cancer patients. Autophagy activated cachectic muscle hosts along with ubiquitin-proteasome pathway (UPP), contributing to accelerated protein degradation and wasting. However, established signaling mechanism that activates autophagy response fasting or denervation does not seem mediate cancer-provoked skeletal myocytes. Here, we show p38β MAPK mediates activation tumor-bearing...
ADCK2 is a member of the AarF domain-containing kinase family, which consists five members, and has been shown to play role in CoQ metabolism. However, ADCKs have also connected cancer cell survival, proliferation motility. In this study, we investigated melanoma.The effect on melanoma motility was evaluated by scratch assay transwell invasion upon siRNA-mediated knockdown or stable overexpression ADCK2.We found that high levels intratumoral MYL6 are associated with higher survival rate...
FTY720, a new chemical substance derived from the ascomycete Isaria sinclairii , is used for treating multiple sclerosis, renal cancer, and asthma. Sphingosine 1-phosphate (S1P) bioactive sphingolipid metabolite exists in red blood cells. FTY720 synthetic S1P analog which can block evoking physiological effects. Recently studies show that was participating activated inflammation cells induced injury. The objective of this study to assess protective effect on kidney damage potential mechanism...
Background Bullous pemphigoid (BP) is a senile chronic autoimmune bullous skin disease with high relapse rate, which significantly impairs patients’ quality of life and contributes to mortality. This observational case-control study explores the gene polymorphisms cytokines their clinical significance in Chinese patients BP. Methods IL-1α (rs1800587), IL-1β (rs16944, rs1143627, rs1143634), IL-4 (rs2243250), IL-6 (rs1800795), IL-10 (rs1800896, rs1800871, rs1800872), IL-13 (rs1800925,...
The present study reports the fabrication of a silver chalcogenolate cluster hybrid membrane (SCC membrane) through self-assembly SCCs, and then covalent cross-linking modified SCC assembled materials. This strategy provides access to clusters with superior chemical stability enhanced luminescence efficiency for practical applications.
Objective: Current evidence has revealed a significant association between bullous pemphigoid (BP) and neurological diseases (ND), including stroke, but the incidence of BP autoantibodies in patients with stroke not previously been investigated. Our study aimed to assess antigen-specific antibodies patients. Design: 100 healthy controls were randomly selected for measurement anti-BP180/230 IgG by enzyme-linked immunosorbent assay (ELISA), salt-split indirect immunofluorescence (IIF)...
Preliminary observation in clinical practice showed that subjective neurocognitive complaints are relatively common bullous pemphigoid (BP) patients. Yet, little has been done to investigate the status BP.This is a multicenter observational case-control study comprised of 61 BP patients and 65 matched control subjects from 3 medical centers China 2014 2019. To evaluate cognitive function between controls, all finished mini-mental state examination (MMSE) montreal assessment (MoCA).The...
Key transcription factors (TFs) play critical roles in zygotic genome activation (ZGA) during early embryogenesis, whereas genome-wide occupancies of only a few have been profiled ZGA due to the limitation cell numbers or lack high-quality antibodies. Here, we present FitCUT&RUN, modified CUT&RUN method, which an Fc fragment immunoglobulin G is used for tagging, profile TF occupancy antibody-free manner and demonstrate its reliability robustness using as 5000 K562 cells. We applied...
The efficacy of adjuvant radiotherapy for postoperative patients with early-stage cervical adenocarcinoma who are lymph node-negative is still inconclusive. Establishing a nomogram to predict the prognosis such could facilitate clinical decision-making.We recruited 4636 eligible pT1-T2aN0M0 between 2004 and 2016 from Surveillance, Epidemiology End Results (SEER) database. Random survival forest (RSF) conditional (CSF) model was used assess prognostic importance each characteristic variable....
An enantiomeric pair of 3d-3d heterometallic clusters {MnIIMnIII12CuII8} has been synthesized in an aqueous solution without heating. The crystal structures reveal a five-layered core {MnIIMnIII12CuII8}, which is slightly distorted {MnIIMnIII12} tetradecahedron with its eight triangular faces capped by CuII ion respectively. magnetic measurement results establish that anisotropic MnIII atom-containing L-1 and D-1 exhibit slow relaxation their magnetization vectors.
Abstract: Bullous pemphigoid (BP) is a senile autoimmune blistering disease with autoantibodies against the basement membrane. Less than 20 cases of localized BP in young adults have been reported and understanding very limited. An unusual location here described. A 30-year-old woman presented 4-month history itchy erythema on her trunk. The lesion, well-demarcated maculopapules bra’s shape, had misdiagnosed as contact dermatitis. Laboratory finding was notable for serum to antigen 180...
Abstract Background Current evidence has revealed a significant association between bullous pemphigoid (BP) and neurological diseases (ND), including stroke, but the incidence of BP autoantibodies in patients with stroke not previously been investigated. Objective Our study aims to assess antigen-specific antibodies patients. Methods 100 healthy controls were randomly selected measure anti-BP180/230 IgG by enzyme-linked immunosorbent assay (ELISA), salt split indirect immunofluorescence...
Abstract The early stages of embryonic development rely on maternal products for proper regulation. However, systematic screening functional maternal-specific factors has been challenging due to the time- and labor-intensive nature traditional approaches. Here, we combined a computational pipeline F0 homozygous mutation technology screen chromatin regulators in zebrafish embryogenesis identified Mcm3l, Mcm6l, Npm2a as playing essential roles DNA replication cell division. Our results...
With the increasing incidence of acute pancreatitis (AP), new-onset hyperglycemia (prediabetes and diabetes) secondary to AP attracts more attention as one chronic complications. There are numerous causes AP, including cholelithiasis, hypertriglyceridemia, alcoholism so forth, which both diabetic high-risk factors. Unfortunately, it is still unknown whether hazards glucose metabolism impairment resulting from different types equal. In addition, person suffered or diabetes with for future...
<title>Abstract</title> Melanoma is an aggressive skin cancer and highly lethal at advanced stages due to its high tumorigenicity metastatic capacity. Changing the phenotype of cells from one lineage another, a process called transdifferentiation, leads tumor cell reversion, which goes along with drastic reduction their tumorigenicity. Via ectopic overexpression four neuronal transcription factors we transdifferentiated melanoma into neuron-like expressing markers showing morphology....
Bullous pemphigoid (BP) is a severe autoimmune sub-epidermal bullous disease. Exosomes are small extracellular vesicles secreted by most cell types. The exosomal membrane proteins implicated in various biological and pathological pathways. This study aims to explore the potential roles of exosomes BP pathomechanism.
The early stages of embryonic development rely on maternal products for proper regulation. However, screening functional maternal-specific factors is challenging due to the time- and labor-intensive nature traditional approaches. Here, we combine a computational pipeline F0 null mutant technology screen chromatin regulators in zebrafish embryogenesis identify Mcm3l, Mcm6l, Npm2a as playing essential roles DNA replication cell division. Our results contribute understanding molecular...