A5101975688- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- MicroRNA in disease regulation
- RNA modifications and cancer
- Single-cell and spatial transcriptomics
- Kruppel-like factors research
- Caveolin-1 and cellular processes
- Catalytic Processes in Materials Science
- Fibroblast Growth Factor Research
- Animal Genetics and Reproduction
- Aldose Reductase and Taurine
- Circular RNAs in diseases
- Cancer-related gene regulation
- Viral Infectious Diseases and Gene Expression in Insects
- Virus-based gene therapy research
- RNA Research and Splicing
- CRISPR and Genetic Engineering
- Nuclear Receptors and Signaling
- RNA regulation and disease
- Autophagy in Disease and Therapy
- Gas Sensing Nanomaterials and Sensors
- Genetics, Aging, and Longevity in Model Organisms
- Advanced Chemical Physics Studies
- Cancer-related molecular mechanisms research
- COVID-19 and Mental Health
Shenzhen Third People’s Hospital
2025
Shenzhen University
2025
Icahn School of Medicine at Mount Sinai
2023-2024
Shanghai East Hospital
2018-2024
Binzhou Medical University
2024
Shanghai First Maternity and Infant Hospital
2023-2024
Chinese Academy of Sciences
2016-2023
Southern Medical University
2022-2023
Xuzhou Medical College
2020-2023
Case Western Reserve University
2008-2022
Abstract Osteosarcoma, an aggressive malignant cancer, has a high lung metastasis rate and lacks therapeutic target. Here, we reported that chromobox homolog 4 (CBX4) was overexpressed in osteosarcoma cell lines tissues. CBX4 promoted by transcriptionally up-regulating Runx2 via the recruitment of GCN5 to promoter. The phosphorylation at T437 casein kinase 1α (CK1α) facilitated its ubiquitination both K178 K280 subsequent degradation CHIP, this could be reduced TNFα. Consistently, CK1α...
Increasing evidence suggests that ion channel genes play an important role in the progression of gliomas. However, mechanisms by which influence glioma are not fully understood. We identified KCNB1 as a novel gene, associated with malignant and favorable overall survival (OS) progression-free (PFS) patients from three datasets (CGGA, GSE16011 REMBRANDT). Moreover, we characterized function autophagy induction accompanied increased apoptosis reduced proliferation invasion cells for KCNB1....
For animals, epigenetic modifications can be globally or partially inherited from gametes after fertilization, and such information is required for proper transcriptional regulation, especially during the process of zygotic genome activation (ZGA). However, mechanism underlying how signatures affect regulation ZGA remains poorly understood. Here, we performed genome-wide profiling chromatin accessibility zebrafish ZGA, which closely related to regulation. We observed a clear trend toward...
CTCF is crucial for chromatin structure and transcription regulation in early embryonic development. However, the kinetics of occupation preimplantation embryos have remained unclear. In this study, we used CUT&RUN technology to investigate occupancy mouse Our findings revealed that begins binding genome prior zygotic activation (ZGA), with a preference CTCF-anchored loops. Although majority consistently maintained, identified specific set sites enriched mouse-specific short interspersed...
To investigate the role of miRNA in controlling human embryonic stem (hES) cell differentiation toward endothelial lineage and chick blood vessel formation, undifferentiated hES cells were first cultured on Matrigel-coated flasks growth medium-2 (EGM-2) to initiate (EC) differentiation. CD146(+) isolated from differentiating expanded vitro. The vitro positive for EC markers, capable Ac-LDL uptake, lectin binding, formation vascular structures vivo. gain/loss-of-function analyses revealed...
Aldo-keto reductase 1C3(AKR1C3) is an enzyme involved in prostaglandins metabolism. Studies suggest that AKR1C3 has a pivotal role the radioresistance of esophageal cancer and non-small-cell lung cancer, yet prostate cells radiation resistance not been clarified. In our study, we established stable overexpressing cell line (AKR1C3-over) derived from DU145 its control (Control). We conducted colony formation assay to determine used chemical inhibitor detect whether it can restored sensitivity...
Emerging spatial omics technologies continue to advance the molecular mapping of tissue architecture and investigation gene regulation cellular crosstalk, which in turn provide new mechanistic insights into a wide range biological processes diseases. Such an increasingly large amount information content at multiple scales. However, representing harmonizing diverse datasets efficiently, including combining modalities or scales scalable flexible manner, remains substantial challenge. Here, we...
Fibroblast growth factor (FGF) receptor 1 (FGFR1) protein was expressed as the long and short well some truncated forms in ovine fetoplacental artery ex vivo vitro. Upon FGF2 stimulation, both FGFR1s were tyrosine phosphorylated PI3K/AKT1 ERK1/2 pathways activated a concentration- time- dependent manner endothelial (oFPAE) cells. Blockade of pathway attenuated FGF2-stimulated cell proliferation migration tube formation; blockade abolished formation partially inhibited did not alter...
Objective— Smooth muscle cell (SMC) migration and proliferation play an essential role in neointimal formation after vascular injury. In this study, we intended to investigate whether the X-box–binding protein 1 (XBP1) was involved these processes. Approach Results— vivo studies on femoral artery injury models revealed that triggered immediate upregulation of XBP1 expression splicing SMCs deficiency significantly abrogated injured vessels. vitro indicated platelet-derived growth factor-BB...
Aqueous zinc-ion batteries (AZIBs) possess a tremendous prospect for large-scale energy storage. Nevertheless, the interfacial stability and cyclic reversibility Zn anode are impeded by unregulated growth of Zn...
Smooth muscle cells (SMCs) are a key component of healthy and tissue engineered vessels play crucial role in vascular development the pathogenic events remodeling i.e. restenosis. However, cell source from which they can be isolated is limited. Embryonic stem (ES) that have remarkable capability to differentiate into SMCs response specific stimuli provide useful model for studying SMC differentiation. Previous studies suggested dickkopf homolog 3 (DKK3) has human partially induced...
Abstract Fetal bovine serum (FBS) shows obvious deficiencies in cell culture, such as low batch to consistency, adventitious biological contaminant risk and high cost, which severely limit the development of culture industry. Sericin protein derived from silkworm cocoon has become increasingly popular due its diverse beneficial characteristics. However, systematic evaluation sericin a substitute for FBS medium remains limited. In this study, we conducted cellular morphological, physiological...
Open AccessCCS ChemistryRESEARCH ARTICLE1 Mar 2022Design of High-Contrast Mechanochromic Materials Based on Aggregation-Induced Emissive Pyran Derivatives Guided by Polymorph Predictions Wen Wang, Ruohan Li, Shuzhang Xiao, Qilin Xing, Xia Yan, Jiayu Zhang, Xinghong Haichuang Lan and Tao Yi Wang College Biological Pharmaceutical Sciences, China Three Gorges University, Hubei, Yichang 443002 , Li Department Chemistry, Fudan Shanghai 200438 Xiao *Corresponding authors: E-mail Address: [email...
Molecular dynamics simulation is performed to investigate how solid surface free energy determines the coalescence-induced jumping of nanodroplet on superhydrophobic surfaces. The nanodroplet-jumping found highly sensitive represented by fluid-solid bonding strength parameter β. coalesced-nanodroplet fails jump off when β 0.15 (contact angle being 145°) while succeeds 0.05 175°). We find that a small proportion (ca. 2%–4%) released in both cases eventually converted kinetic direction, which...
Recent technological developments have made it possible to map the spatial organization of a tissue at single-cell resolution. However, computational methods for analyzing spatially continuous variations in microenvironment are still lacking. Here we present ONTraC as strategy that constructs niche trajectories using graph neural network-based modeling framework. Our benchmark analysis shows performs more favorably than existing reconstructing trajectories. Applications public...