A5073267756- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Radiomics and Machine Learning in Medical Imaging
- AI in cancer detection
- Viral gastroenteritis research and epidemiology
- Head and Neck Cancer Studies
- Artificial Intelligence in Healthcare and Education
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- COVID-19 epidemiological studies
- Cervical Cancer and HPV Research
- Animal Disease Management and Epidemiology
- Influenza Virus Research Studies
- Cancer-related molecular mechanisms research
- Inflammasome and immune disorders
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Traditional Chinese Medicine Studies
- Viral Infections and Immunology Research
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Anesthesia and Sedative Agents
- Foreign Body Medical Cases
- UAV Applications and Optimization
Huazhong University of Science and Technology
2016-2024
Central Hospital of Wuhan
2016-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Shaoxing University
2023
Xi'an Technological University
2023
Yuhuangding Hospital
2020
Weifang Medical University
2020
Jiangsu University
2017
Xuzhou Cancer Hospital
2017
Zaozhuang Municipal Hospital
2017
Abstract Interleukin ( IL )‐1β plays an important role in the pathogenesis of idiopathic pulmonary fibrosis. The production ‐1β is dependent upon caspase‐1‐containing multiprotein complexes called inflammasomes and ‐1R1/MyD88/ NF ‐κB pathway. In this study, we explored whether a potential anti‐fibrotic agent fluorofenidone FD ) exerts its anti‐inflammatory effects through suppressing activation NACHT, LRR PYD domains‐containing protein 3 (NALP3) inflammasome ‐1β/ pathway vivo vitro . Male...
ABSTRACT Background and objective: The effects of corticosteroid treatment on non-severe COVID-19 pneumonia patients are unknown. To determine the impacts adjuvant administrated to with pneumonia. Method: A retrospective cohort study based propensity score analysis was designed explore several clinical outcomes. Results: One hundred thirty-two satisfied inclusion criteria 35 pairs were generated according matching. Compared non-corticosteroid group, CT day 7 significantly higher in group...
ABSTRACT The rapid increase in Mycobacterium tuberculosis resistance to ethambutol (EMB) threatens the diagnosis and treatment of (TB). We investigated role mutations embC-embA intergenic region (IGR) EMB-resistant clinical strains from east China. A total 767 M. were collected analyzed for their drug susceptibility EMB using MGIT 960 system MIC assay, IGRs these sequenced. transcriptional activity IGR was examined by reporter gene assays recombinant smegmatis strains, effect on its binding...
The purpose of this study was to investigate the effect human antigen R (HuR) downregulation and potential target genes HuR on progression esophageal squamous cell carcinoma (ESCC).In study, a proteomics assay used detect expression proteins after downregulation, luciferase presence binding site 3'-untranslated region (3'-UTR) interleukin 18 (IL-18). In addition, colony formation assay, MTT, EdU incorporation Western blot, flow cytometry, immunohistochemistry, transwell invasion wound...
Tobacco use and heavy alcohol consumption are risk factors for head neck cancer (HNC), including oral, pharynx, larynx cancer. No study has investigated the preventable burden of HNC attributable to tobacco in China. We extracted data from 1990 2019 Global Burden Disease. The was estimated by subtracting overlapping fraction derived a literature search. Descriptive analyses were performed initially, followed joinpoint regression age-period-cohort (APC) analysis. future forecasted using...
Abstract Background Influenza is a common illness for its high rates of morbidity and transmission. The implementation non-pharmaceutical interventions (NPIs) during the COVID-19 pandemic to manage dissemination could affect transmission influenza. Methods A retrospective analysis, between 2018 2023, was conducted examine incidence influenza virus types B among patients in sentinel cities located North or South China as well Wuhan City. For validations, data on total count from 2023 were...
Abstract The unmanned aerial vehicle (UAV) assisted mobile edge computing (MEC) system leverages the high maneuverability of UAVs to provide efficient services terminals. A dynamic deployment algorithm based on double deep Q-networks (DDQN) is suggested address issues with energy limitation and obstacle avoidance when providing terminals by UAV. First, consumption UAV fairness terminal’s geographic location are jointly optimized in case multiple obstacles ground. And can avoid obstacles....
The ability of Shigella to invade, colonize, and eventually kill host cells is influenced by many virulence factors. However, there no analysis related genes in Jiangsu Province China so far. flexneri was collected from 13 cities through the provincial Centers for Disease Control (CDC) distribution major (ipaH, ipaBCD, ial, virF, virB, sigA, set1A, sepA, sat, pic, set1B sen) detected PCR technology.A total 545 isolates received were confirmed as S. which belongs 11 serotypes flexneri, among...
Abstract Porcine reproductive and respiratory syndrome (PRRS) virus is an RNA that replicates in the cytoplasm, but viral nucleocapsid (N) protein localizes specifically nucleus nucleolus of virus-infected cells. Nuclear localization N non-essential for PRRSV replication cultured cells has been shown to modulate pathogenesis pigs, suggesting plays accessory role during infection. We identified by yeast two-hybrid screening inhibitor MyoD family-a (I-mfa) domain-containing (HIC) as a cellular...
As a paramyxovirus, Newcastle disease virus (NDV) has the ability to edit its P (phosphoprotein) gene synthesize three kinds of viral protein (P, V and W).It is technically very diffi cult diff erentiate P, W mRNAs, little was known about NDV regulation RNA-editing frequency.To investigate rules RNA editing, ratio gene-derived transcripts W) determined by sequencing at erent time points post-infection.Th e results showed unstable mRNA points, frequency editing signifi cantly increased early...
Abstract Accumulating evidence has demonstrated that high‐risk human papillomaviruses (HR‐HPVs) are involved in the etiology of a subset oropharyngeal squamous cell carcinoma (OPSCC). In this regard, International Agency for Research on Cancer (IARC) recommended direct molecular HPV testing. So far, there is no agreement most appropriate method detection OPSCC formalin‐fixed paraffin‐embedded (FFPE) materials. study, we aimed to evaluate performance high‐sensitive SureX assay FFPE tissues...
In the present study, we studied mechanism of mitochondrial ATP-sensitive potassium (mitoKATP) channels regulating hypoxia-inducible factor (HIF)-1α/microRNA (miR)-210/mitochondrial iron-sulfur protein integrin (ISCU) signaling axis and forming a positive feedback loop in chronic hypoxia-induced pulmonary arterial hypertension (PAH) by using vivo animal model. Two hundred healthy adult SPF Sprague-Dawley rats were randomly divided into five groups: Control, mimic miR-210 agent (mimic-210)...
ABSTRACT Idiopathic pulmonary fibrosis is defined as a specific form of chronic, progressive fibrosing interstitial pneumonia unknown cause. Interleukin (IL)-11 plays an important role in the pathogenesis idiopathic fibrosis. In this study, we explore whether potential antifibrotic agent fluorofenidone (FD) exerts its anti-inflammatory and effects through suppressing activation IL-11/MEK/ERK signaling pathway vivo vitro. Male C57BL/6 J mice were intratracheally injected with bleomycin or...
Abstract Background Foreign body aspiration (FBA) is a serious condition with high morbidity and mortality rates. Although chest radiography generally the first radiologic modality used in diagnosis, substantial percentage of foreign bodies are radiolucent adults diagnosis challenging. Methods Retrospective review adult patients FBA diagnosed by flexible electronic bronchoscopy from 2012 to 2022 collecting demographics, history, hospital presentation, radiographic, operative details. Risk...