A5022468819- Diabetes Treatment and Management
- Genetic Associations and Epidemiology
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Diabetes Management and Research
- Liver Disease Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Telomeres, Telomerase, and Senescence
- Gestational Diabetes Research and Management
- Cancer, Lipids, and Metabolism
- Bariatric Surgery and Outcomes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolomics and Mass Spectrometry Studies
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Cardiovascular Disease and Adiposity
- Bioinformatics and Genomic Networks
- MicroRNA in disease regulation
- Chronic Disease Management Strategies
- Pregnancy and preeclampsia studies
- Prostate Cancer Treatment and Research
- Pelvic floor disorders treatments
- Circular RNAs in diseases
- Obesity, Physical Activity, Diet
- Frailty in Older Adults
Chinese University of Hong Kong
2021-2025
Prince of Wales Hospital
2022-2025
Second Affiliated Hospital of Zhengzhou University
2017-2019
University of Hong Kong
2017
Abstract INTRODUCTION Alzheimer's disease (AD) is a progressive neurodegenerative and the leading cause of dementia. Recent research highlights meningeal lymphatics as key regulators in neurological diseases, suggesting that enhancing their drainage function could be potential therapeutic strategy for AD. Our proof‐of‐concept study demonstrated cranial bone transport can improve lymphatic promote ischemic stroke recovery. METHODS This defined maneuver (CBM) technique. After osteotomy, small...
OBJECTIVE Several studies support associations between relative leukocyte telomere length (rLTL), a biomarker of biological aging and type 2 diabetes. This study investigates the relationship rLTL risk glycemic progression in patients with RESEARCH DESIGN AND METHODS In this cohort study, consecutive Chinese diabetes (N = 5,506) from Hong Kong Diabetes Register stored baseline DNA available follow-up data were studied. was measured using quantitative PCR. Glycemic defined as new need for...
Epigenetic markers are potential biomarkers for diabetes and related complications. Using a prospective cohort from the Hong Kong Diabetes Register, we perform two independent epigenome-wide association studies to identify methylation associated with baseline estimated glomerular filtration rate (eGFR) subsequent decline in kidney function (eGFR slope), respectively, 1,271 type 2 subjects. Here show 40 (30 previously unidentified) eight (all CpG sites individually reach significance eGFR...
To investigate the expression of long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in renal ischemia-reperfusion injury and explore its role acute kidney injury.18 mice were randomly divided into a sham operation group (Sham) an (IR) which animals sacrificed at 6 h or 12 after surgery. The kidneys harvested to measure MALAT1 mRNA. HK2 cells treated with cobalt chloride (CoCl2) mimic hypoxia transfected siRNA knockdown before CoCl2 treatment. After that, was...
Long non-coding RNA (lncRNA) is a kind of with transcripts more than 200 bp in length. LncRNA can interact the miRNA as competing endogenous (ceRNA) to regulate expression target genes, which play significant role initiation and progression tumors. In this study, we explored functional roles regulatory mechanisms lncRNAs ceRNAs gastric cancer, their potential implications for prognosis. The lncRNAs, miRNAs, mRNAs profiles 375 cancer tissues 32 non-tumor were downloaded from Cancer Genome...
ABSTRACT Background Polycystic ovary syndrome (PCOS) is one of the commonest gyneco‐endocrine disorders amongst women reproductive age. Whether PCOS and cardiometabolic traits in patients are associated with shortened telomere length (TL) or relative leukocyte (rLTL) remains unclear. Methods 214 age‐matched were recruited. rLTL was measured an updated quantitative real‐time PCR protocol reported as ΔΔCt between a single‐copy gene encoding β‐globin to normalisation control. A two‐way...
To identify and validate causal protein targets that may serve as potential therapeutic interventions for both the onset progression of Parkinson's disease (PD) through integrative proteomic genetic analyses. We utilized large-scale plasma brain quantitative trait loci (pQTL) datasets from deCODE Health study Religious Orders Study/Rush Memory Aging Project (ROS/MAP), respectively. Proteome-wide association studies (PWAS) were conducted using OTTERS framework proteins FUSION tool proteins,...
People with type 2 diabetes are increasingly susceptible to complications that not specific diabetes. We aimed examine the temporal trajectories of hospitalisations for traditional and non-traditional in people included 758,254 incident between 2002 2018 Hong Kong, followed up until 2019. 72 selected diseases all-cause deaths. derived based on pairs disease associations identified trajectory clusters using Markov Cluster Algorithm. During a median follow-up 7.8 (IQR: 4-12) years, 57.6%...
Background/Objectives: Recently, the term metabolic dysfunction-associated steatotic liver disease (MASLD) has replaced non-alcoholic fatty (NAFLD). Through analysis of trends and disparities regarding cardiovascular (CVD) among individuals with MASLD, identifying leading cause death in this population is crucial. Methods: We conducted a cross-sectional National Health Nutrition Examination Survey (NHANES) III (1988–1994) NHANES 2017–2020 data. MASLD was identified by using clinical profiles...
Papillary renal cell carcinoma (PRCC) is the second most common subtype of carcinoma, and it lacks effective therapeutic targets prognostic molecular biomarkers. Attention has been increasingly focused on long noncoding RNAs (lncRNAs), which can act as competing endogenous RNA (ceRNA) to compete for shared microRNAs (miRNAs) in tumorigenesis human tumors. Therefore, clarify functional roles lncRNAs with respect mediated ceRNA network PRCC, we comprehensively integrated expression profiles,...