A5100382777- Osteoarthritis Treatment and Mechanisms
- Bone Metabolism and Diseases
- Bone health and treatments
- Cancer-related molecular mechanisms research
- Silk-based biomaterials and applications
- Knee injuries and reconstruction techniques
- Periodontal Regeneration and Treatments
- Cerebrospinal fluid and hydrocephalus
- Spinal Dysraphism and Malformations
- Tendon Structure and Treatment
- Mesenchymal stem cell research
- Phytochemistry and Bioactive Compounds
- Neonatal Respiratory Health Research
- Bone and Joint Diseases
- Regional Development and Environment
- Phagocytosis and Immune Regulation
- Plant Molecular Biology Research
- Adenosine and Purinergic Signaling
- Forest, Soil, and Plant Ecology in China
- Apelin-related biomedical research
- Immune cells in cancer
- Traumatic Brain Injury and Neurovascular Disturbances
- Phytochemical compounds biological activities
- Macrophage Migration Inhibitory Factor
- Pomegranate: compositions and health benefits
Chinese University of Hong Kong
2018-2025
Prince of Wales Hospital
2018-2025
Chinese Academy of Sciences
2024-2025
Shenzhen Institutes of Advanced Technology
2025
Chinese University of Hong Kong, Shenzhen
2023
Northeast Agricultural University
2023
Sun Yat-sen University
2015-2018
The First Affiliated Hospital, Sun Yat-sen University
2015-2018
Functional tissue engineering strategies provide innovative approach for the repair and regeneration of damaged cartilage. Hydrogel is widely used because it could rapid defect filling proper structure support, biocompatible cell aggregation matrix deposition. Efforts have been made to seek suitable scaffolds cartilage engineering. Here Alg-DA/Ac-β-CD/gelatin hydrogel was designed with features physical chemical multiple crosslinking self-healing properties. Gelation time, swelling ratio,...
Lacking self-repair abilities, injuries to articular cartilage can lead degeneration and ultimately result in osteoarthritis. Tissue engineering based on functional bioactive scaffolds are emerging as promising approaches for regeneration repair. Although the use of cell-laden prior implantation regenerate repair lesions some extent, these still restricted by limited cell sources, excessive costs, risks disease transmission complex manufacturing practices. Acellular through recruitment...
Advanced glycation end products (AGEs) disturb bone remodeling during aging, and this process is accelerated in diabetes. However, their role modulation of osteoclast-induced resorption controversial, with some studies indicating that AGEs enhance others showing the opposite effect. We determined whether present at different stages osteoclast differentiation affect differently. Based on increased levels tartrate-resistant acid phosphatase (TRAP) cathepsin K (CTSK), we identified day 4...
Osteoarthritis (OA) is the most common joint disease; thus, understanding pathological mechanisms of OA initiation and progression critical for treatment. MicroRNAs (miRNAs) have been shown to be involved in osteoarthritis, one candidate microRNA-378 (miR-378), which highly expressed synovium patients during late-stage disease, but its function underlying how it contributes disease remain poorly understood. In this study, miR-378 transgenic (TG) mice were used study role development. TG...
Abstract The mechanism of extracellular ligand nano‐geometry in ex vivo T cell activation for immunotherapy remains elusive. Herein, the authors demonstrate large aspect ratio (AR) gold nanorods (AuNRs) conjugated on culture substrate enhancing both murine and human through nanoscale anisotropic presentation stimulatory ligands (anti‐CD3(αCD3) anti‐CD28(αCD28) antibodies). AuNRs with AR bearing αCD3 αCD28 antibodies significantly promote expansion key cytokine secretion including...
Abstract The death of osteoblasts induced by glucocorticoid (GC)-mediated oxidative stress plays a crucial role in the development steroid-induced osteonecrosis femoral head (SIONFH). Improving bone formation driven has shown promising outcomes prognosis SIONFH. Isovitexin demonstrated antioxidant properties, but its therapeutic effects on GC-induced and SIONFH remain unexplored. In this study, we analyzed clinical samples obtained from patients using proteomic bioinformatic approaches. We...
Abstract INTRODUCTION Alzheimer's disease (AD) is a progressive neurodegenerative and the leading cause of dementia. Recent research highlights meningeal lymphatics as key regulators in neurological diseases, suggesting that enhancing their drainage function could be potential therapeutic strategy for AD. Our proof‐of‐concept study demonstrated cranial bone transport can improve lymphatic promote ischemic stroke recovery. METHODS This defined maneuver (CBM) technique. After osteotomy, small...
Ischemic stroke is a leading cause of death and disability worldwide. However, the time window for quickly dissolving clots restoring cerebral blood flow, using tissue-type plasminogen activator treatment rather limited, resulting in many patients experiencing long-term functional impairments if not death. This study aims to determine roles cranial bone transport (CBT), novel, effective, simple surgical technique, recovery ischemic middle artery occlusion (MCAO) rat model.CBT was performed...
Osteoporotic fracture has been regarded as one of the most common bone disorders in aging society. The natural herb-derived small molecules were revealed potential treatment approaches for osteoporotic healing. Sesamin is a member lignan family, which possesses estrogenic activity and plays significant role modulating homeostasis. Our previous study reported promoting effect sesamin on postmenopausal osteoporosis treatment. However, healing not well studied yet. In this study, we further...
Exercise in later life is important for bone health and delays the progression of osteoporotic loss. Osteocytes are major cells responsible transforming mechanical stimuli into cellular signals through their highly specialized lacunocanalicular networks (LCN). Osteocyte activity LCN degenerate with aging, thus might impair effectiveness exercise on health; however, underlying mechanism clinical implications remain elusive. Herein, we showed that deletion Sirt3 osteocytes could formation...
The aim of the present study was to investigate role microRNA (miR)‑27a‑3p in osteoarthritis (OA). Reverse transcription‑quantitative polymerase chain reaction and western blotting were performed determine expression miR‑27a‑3p aggrecanase‑2 (ADAMTS5) cartilage tissues from patients with OA healthy controls, also interleukin (IL)‑1β‑treated primary human chondrocytes. Primary chondrocytes transfected miR‑27a‑3p. A luciferase reporter assay used validate direct contact between its putative...
Introduction Emerging evidence suggests long non‐coding RNA (lncRNA) H19 is associated with osteoarthritis (OA) pathology. However, how contributes to OA has not been reported. This study aims investigate the biological function of in subchondral bone remodeling and progression. Methods Clinical joint samples animal models induced by medial meniscus destabilization (DMM) surgery were used verify causal relationship between osteocyte cartilage changes. MLO‐Y4 cells subjected fluid shear...
High-elevation and cold regions have harsh natural conditions with low temperatures intense ultraviolet radiation, which impede plant growth maintenance. Therefore, soil water conservation vegetation restoration models are of great significance. In this study, a site condition analysis was performed based on three main limiting factors, including climatic meteorological, soil, topographic geomorphological providing basis for restoration. The study area divided into different types. After...
Abstract Background Low-temperature chilling is a major abiotic stress leading to reduced rice yield and significant environmental threat food security. studies have focused on physiological changes or coding genes. However, ceRNA mechanism in at low temperatures has not been reported. Therefore, establish the network elucidate transcriptional regulatory of leaves response low-temperature stress, experiments were conducted using two (Oryza sativa. L) varieties with significantly different...