A5028964102- Electromagnetic Fields and Biological Effects
- Spine and Intervertebral Disc Pathology
- Bone health and osteoporosis research
- Musculoskeletal pain and rehabilitation
- Bone Tissue Engineering Materials
- Shoulder Injury and Treatment
- Shoulder and Clavicle Injuries
- Spinal Fractures and Fixation Techniques
- Tendon Structure and Treatment
- Orthopaedic implants and arthroplasty
- Spaceflight effects on biology
- Cervical and Thoracic Myelopathy
- Wireless Body Area Networks
- Carbon Nanotubes in Composites
- Pain Management and Treatment
- Sports injuries and prevention
- Laser Applications in Dentistry and Medicine
- Biofield Effects and Biophysics
- Bone Metabolism and Diseases
- Advanced MRI Techniques and Applications
- Biomedical Ethics and Regulation
- Craniofacial Disorders and Treatments
- Bone fractures and treatments
- Osteoarthritis Treatment and Mechanisms
- Orthopedic Surgery and Rehabilitation
Cleveland Clinic
2025
Orthofix (United States)
2014-2022
Metamagnetics (United States)
2022
HealthPartners
2022
University of Michigan
2004-2020
Michigan Medicine
2020
Orthopaedic Research Laboratories
2006-2009
<h2>Abstract</h2><h3>Background Context</h3> The most commonly used materials for interbody cages are titanium metal and polymer polyetheretherketone (PEEK). Both of these have demonstrated good biocompatibility. A major disadvantage associated with solid is their radiopacity, limiting the postoperative monitoring spinal fusion via standard imaging modalities. However, PEEK radiolucent, allowing a temporal assessment mass by clinicians. On other hand, hydrophobic, which can limit bony...
Functional tissue engineering strategies provide innovative approach for the repair and regeneration of damaged cartilage. Hydrogel is widely used because it could rapid defect filling proper structure support, biocompatible cell aggregation matrix deposition. Efforts have been made to seek suitable scaffolds cartilage engineering. Here Alg-DA/Ac-β-CD/gelatin hydrogel was designed with features physical chemical multiple crosslinking self-healing properties. Gelation time, swelling ratio,...
The post-surgery integrity of the tendons and muscle quality are two major factors in success rotator cuff (RC) repair. Though surgical techniques for repair have significantly improved past decades, there no effective treatments to improve tendon-to-bone healing after at this point time. Pulsed electromagnetic fields (PEMF) previously been used promoting fracture healing. Previous studies shown that PEMF has a positive role osteoblast precursors proliferation differentiation. However, PEMFs...
Rotator cuff tears are common musculoskeletal injuries often requiring surgical intervention with high failure rates. Currently, pulsed electromagnetic fields (PEMFs) used for treatment of long-bone fracture and lumbar cervical spine fusion surgery. Clinical studies examining the effects PEMF on soft tissue healing show promising results. Therefore, we investigated role rotator using a rat repair model. We hypothesized that exposure following would improve tendon mechanical properties,...
The interactions between interbody devices, corpectomy cages, and vertebral bodies are influenced by surface characteristics such as roughness waviness, impacting fusion quality patient outcomes. Understanding morphology is crucial for improving cage design avoiding complications like subsidence, neural injury, re-operation. This study aims to characterize the variability in along spine. A retrospective analysis of a spinal CT scan database 159 patients (mean age 59±17) from an open-source...
Single walled carbon nanotubes (SWNT) produced by the anodic arc discharge over a range of constant background pressures helium (100–1000 Torr) were examined under high-resolution transmission electron microscope, and Raman spectrometer. It was found that average SWNT diameter is about 2 nm fairly independent pressure. Analysis relative purity SWNTs samples suggests highest concentration can be obtained at pressure 200–300 Torr. Measured anode ablation rate increases linearly with The model...
Trinity Evolution® (TE), a viable cellular bone allograft, previously demonstrated high fusion rates and no safety-related concerns after single-level anterior cervical discectomy (ACDF) procedures. This prospective multicenter clinical study was performed to assess the radiographic outcomes of TE in subjects undergoing two-level ACDF In prospective, study, 40 that presented with symptomatic degeneration at two adjacent vertebral levels underwent instrumented using autograft substitute...
The members of the huntingtin-interacting protein-1 (HIP1) family, HIP1 and HIP1-related (HIP1r), are multi-domain proteins that interact with inositol lipids, clathrin actin. is over-expressed in a variety cancers both HIP1r prolong half-life multiple growth factor receptors. To better understand physiological importance family vivo , we have analyzed large cohort double Hip1/Hip1r knockout (DKO) mice. All DKO mice were dwarfed, afflicted severe vertebral defects died early adulthood. These...
A model of the arc discharge used for a single wall carbon nanotube (SWNT) synthesis is developed. Coupling solution non-equilibrium, Knudsen layer, with hydrodynamic layer and column provides self-consistent ablation rate plasma parameter distribution. It predicted that interelectrode gap decreases background pressure increase. Conditions formation in method are described. Carbon seed charging found to be very important effects may alter cathode region. This predicts long nanotubes high...
Abstract Bone remodeling is necessary to avoid microdamage accumulation, which could lead whole-bone failure. Previous studies have shown that this bone-repair mechanism triggered by osteocyte apoptosis. Through the use of a rodent hindlimb suspension model and tibial four-point bending model, effects disuse on was examined. At day 0, male rats were assigned one three groups: weight bearing (WB), (HS), or with daily intermittent following damage-inducing loading (HW). Within each group,...
Abstract Pro‐inflammatory cytokines are recognized contributors to intervertebral disc (IVD) degeneration and discogenic pain. We have recently reported the anti‐inflammatory effect of pulsed electromagnetic fields (PEMF) on IVD cells in vitro. Whether these potentially therapeutic effects sufficiently potent influence health vivo has not been demonstrated. report here PEMF acute inflammation arising from a rat‐tail injury model. Disc was induced by percutaneously stabbing Co6‐7, Co7‐8,...
Distraction Osteogenesis (DO) is a widely used surgical procedure for limb lengthening, deformity correction, and management of segmental bone defects. However, delayed consolidation during DO remains an unsolved clinical problem, which significantly negatively affects the quality healing outcome. Pulsed electromagnetic field (PEMF) therapy has been shown to promote osteogenesis exhibit beneficial effects on union nonunion fractures. Thus, we hypothesize that PEMF could have DO. In this...
Pain and disability due to age-related spinal disorders are increasing a more active population placing greater demands on their musculoskeletal system. For patients requiring surgery, fusion is typically indicated. Interbody cages improve rates restore lordosis, disc height, foraminal height. Static offered in multiple conformations account for anatomic variability; however, they have issues related implant subsidence loss of lordosis. Expandable were developed address these...
Abstract Introduction Cellular bone matrices (CBM) are allograft products that provide three components essential to new formation: an osteoconductive scaffold, extracellular growth factors for cell proliferation and differentiation, viable cells with osteogenic potential. This is emerging technology being applied augment spinal fusion procedures as alternative autografts. Methods We aim compare the ability of six commercially‐available human CBMs (Trinity ELITE®, ViviGen®, Cellentra®,...
Abstract Rotator cuff repair failure remains common due to poor tendon healing, particularly at the enthesis. We previously showed that pulsed electromagnetic field (PEMF) therapy improved mechanical properties of rat supraspinatus postoperatively. However, little is known about mechanisms behind PEMF‐dependent contributions healing in this injury model. The objective study was determine influence PEMF treatment on gene expression and cell composition, as well bone microarchitecture dynamic...
Polyetheretherketone (PEEK) titanium composite (PTC) is a novel interbody fusion device that combines PEEK core with alloy (Ti6Al4V) endplates. The present study aimed to investigate the in vitro biological reactivity of human bone-marrow-derived mesenchymal stem cells (hBM-MSCs) micro- and nanotopographies produced by an acid-etching process on surface 3D-printed PTC Optical profilometer scanning electron microscopy were used assess roughness identify nano-features etched or unetched...
The Achilles tendon is frequently injured. Data to support specific treatment strategies for complete and partial tears inconclusive. Regardless of treatment, patients risk re-rupture typically have long-term functional deficits. We previously showed that pulsed electromagnetic field (PEMF) therapy improved tendon-to-bone healing in a rat rotator cuff model. This study investigated the effects PEMF on ankle function properties after (i) tear repair with immobilization, (ii) without (iii)...