A5058145060- Pharmacological Effects of Natural Compounds
- Apelin-related biomedical research
- Osteoarthritis Treatment and Mechanisms
- Transplantation: Methods and Outcomes
- Cancer-related molecular mechanisms research
- Sirtuins and Resveratrol in Medicine
Chinese University of Hong Kong
2022-2024
Prince of Wales Hospital
2024
Nanjing Drum Tower Hospital
2024
Exercise in later life is important for bone health and delays the progression of osteoporotic loss. Osteocytes are major cells responsible transforming mechanical stimuli into cellular signals through their highly specialized lacunocanalicular networks (LCN). Osteocyte activity LCN degenerate with aging, thus might impair effectiveness exercise on health; however, underlying mechanism clinical implications remain elusive. Herein, we showed that deletion Sirt3 osteocytes could formation...
Introduction Emerging evidence suggests long non‐coding RNA (lncRNA) H19 is associated with osteoarthritis (OA) pathology. However, how contributes to OA has not been reported. This study aims investigate the biological function of in subchondral bone remodeling and progression. Methods Clinical joint samples animal models induced by medial meniscus destabilization (DMM) surgery were used verify causal relationship between osteocyte cartilage changes. MLO‐Y4 cells subjected fluid shear...