A5029253149- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Retinal Development and Disorders
- Effects and risks of endocrine disrupting chemicals
- Photoreceptor and optogenetics research
- Renal and related cancers
- Neurogenesis and neuroplasticity mechanisms
- Microbial infections and disease research
- Nerve injury and regeneration
- Microtubule and mitosis dynamics
- Estrogen and related hormone effects
- Spinal Cord Injury Research
- Neurogenetic and Muscular Disorders Research
- Hormonal Regulation and Hypertension
- Wnt/β-catenin signaling in development and cancer
- Testicular diseases and treatments
- Retinal Diseases and Treatments
- Hormonal and reproductive studies
- Carcinogens and Genotoxicity Assessment
- Herpesvirus Infections and Treatments
- Bacteriophages and microbial interactions
- Aquaculture disease management and microbiota
- Reproductive System and Pregnancy
- Neuroinflammation and Neurodegeneration Mechanisms
- Photochromic and Fluorescence Chemistry
Wenzhou Medical University
2016-2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2016-2025
Second Affiliated Hospital of Guangzhou Medical University
2024-2025
Guangzhou Medical University
2023-2025
Fudan University
2024
State Key Laboratory of Genetic Engineering
2024
Southwest Petroleum University
2024
Qilu Hospital of Shandong University
2022-2024
Ministry of Education of the People's Republic of China
2024
Nanchang University
2019-2023
Abstract We have examined the ability of different neurotrophic and growth factors to prevent axotomy‐induced motoneuron cell death in developing mouse spinal cord. After postnatal unilateral section sciatic nerve, most (MN) loss occurs lateral motor column fourth lumbar segment (L4). Significant occurred after surgery performed on or before day (PN) 5. In contrast, no significant was found when axotomy PN10. Axotomy PN2 PN5 resulted a 44% L4 motoneurons by 7 days, 66% 10 days postsurgery....
ABSTRACT Phage-coded lysin is an enzyme that destroys the cell walls of bacteria. Phage could be alternative to conventional antibiotic therapy against pathogens are resistant multiple antibiotics. In this study, a novel staphylococcal phage, GH15, was isolated, and endogenous lytic (LysGH15) expressed purified. The LysGH15 displayed broad spectrum; in vitro treatment killed number Staphylococcus aureus strains rapidly completely, including methicillin-resistant S. (MRSA). animal...
A Ca2+ signaling model is proposed to consider the crosstalk of ions between endoplasmic reticulum (ER) and mitochondria within microdomains around inositol 1, 4, 5-trisphosphate receptors (IP3R) mitochondrial uniporter (MCU). Our predicts that there a critical IP3R-MCU distance at which 50% ER-released taken up by modulate signals differently when outside this distance. This study highlights importance on dynamics. The MCU are too closely associated with IP3Rs, enhanced uptake will produce...
Pigment epithelium-derived factor (PEDF) is a member of the serine protease inhibitor (serpin) superfamily that has been shown previously to promote survival and/or differentiation rat cerebellar granule neurons and human retinoblastoma cells in vitro. However, contrast most serpins, PEDF no inhibitory activity against any known proteases, its described biological activities do not appear require serpin-reactive loop located toward carboxy end polypeptide. Because another serpin, nexin-1,...
In the present study, we examined effects of glial cell line-derived neurotrophic factor (GDNF), brain-derived (BDNF), ciliary (CNTF), and insulin growth (IGF-1) on adult motoneuron survival following spinal root avulsion. The expression neuronal nitric oxide synthase (nNOS), c-Jun, low-affinity neurotrophin receptor (P75) treatment with these factors was also examined. control animals, approximately 80% motoneurons were nNOS positive at 3 weeks lesion, whereas in GDNF or BDNF treated...
Experimental lesions have been used widely to induce motoneuron (MN) degeneration as a model test the ability of different trophic molecules prevent lesion-induced alterations. However, morphological mechanisms spinal MN death following types is not clear at present time. In this study, we characterized characteristics cell by examining DNA fragmentation and ultrastructural light microscopic features MNs nerve injury (i.e., axotomy avulsion) in developing adult mouse. neonatal mice, induced...
Background Endometriosis is recognized as an estrogen-dependent inflammation disorder, estimated to affect 8%-15% of women childbearing age. Currently, the etiology and pathogenesis endometriosis are not completely clear. Underlying mechanism for still under debate needs further exploration. The involvement transcription factors immune mediations may be involved in pathophysiological process endometriosis, but specific remains explored. This study aims investigate underlying molecular...
Abstract Environmental toxicants, such as cadmium, found in foods, water, and consumer products are known to induce male reproductive dysfunction. However, the underlying molecular mechanism(s) by which cadmium-induced Sertoli cell injury manifested a disruption of blood-testis barrier (BTB) remains unknown. Interestingly, one primary targets cadmium toxicity testis is cytoskeletons cells, which, turn, impedes junctions seminiferous epithelium. In order expand these earlier observations...
Abstract Background Porcine reproductive and respiratory syndrome virus (PRRSV) Streptococcus suis are common pathogens in pigs. In samples collected during the porcine high fever (PHFS) outbreak many parts of China, PRRSV S. serotype 7 (SS7) have always been isolated together. To determine whether PRRSV-SS7 coinfection was cause PHFS outbreak, we evaluated pathogenicity and/or SS7 a pig model single mixed infection. Results Respiratory disease, diarrhea, anorexia were observed all infected...
The mechanism that regulates sperm release at spermiation is unknown. Herein, we used an animal model wherein rats were treated with adjudin, 1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide, via oral gavage to induce premature of elongating/elongated spermatids, followed by round spermatids and spermatocytes. Spermatid mimicking occurred within 6 12 hours following adjudin treatment and, 96 hours, virtually all tubules devoid spermatids. Using this model, tracked the organization F-actin...