A5057326920- Kawasaki Disease and Coronary Complications
- Inflammasome and immune disorders
- Drug-Induced Hepatotoxicity and Protection
- Pharmacological Effects of Natural Compounds
- Vasculitis and related conditions
- Liver Disease Diagnosis and Treatment
- Renal Diseases and Glomerulopathies
- Drug Transport and Resistance Mechanisms
- Autoimmune and Inflammatory Disorders Research
- Atherosclerosis and Cardiovascular Diseases
- Phytochemistry and biological activity of medicinal plants
- Mycotoxins in Agriculture and Food
- Mechanical Circulatory Support Devices
- Immune Response and Inflammation
- Lipid metabolism and disorders
- Vitamin D Research Studies
- Coronary Artery Anomalies
- Platelet Disorders and Treatments
- Autophagy in Disease and Therapy
- Blood Coagulation and Thrombosis Mechanisms
- Liver Diseases and Immunity
- Streptococcal Infections and Treatments
- Toxin Mechanisms and Immunotoxins
- Ubiquitin and proteasome pathways
- Herpesvirus Infections and Treatments
National Institute of Biological Sciences, Beijing
2016-2025
Wuhan Children's Hospital
2014-2025
Beijing Normal University
2025
Huazhong University of Science and Technology
2007-2024
Jacksonville College
2024
Mayo Clinic in Florida
2024
Wuhan Medical Center for Women and Children
2022
Tongji Hospital
2007-2019
International Peace Maternity & Child Health Hospital
2018
Shanghai Jiao Tong University
2018
Aims: Emodin is an anthraquinone with potential anti-inflammatory properties. However, the possible molecular mechanisms and protective effects of emodin are not clear. The objective this study was to investigate on lipopolysaccharide (LPS)-induced acute liver injury (ALI) via Toll-like receptor 4 (TLR4) signaling pathway in Raw264.7 cell line Balb/c mice. Methods: This established inflammatory cellular model induced ALI animal model. TLR4 overexpressed by lentivirus downregulated small...
Henoch-Schönlein Purpura (HSP) is a common systemic vasculitis in children that often involves the gastrointestinal system (GIS). Identifying reliable predictive markers for GIS complications crucial early intervention and improved patient outcomes. This study aims to identify laboratory of with HSP using machine learning approach. retrospective included diagnosed control group from May 2020 January 2024. Detailed demographic data, including WBC count, lymphocyte neutrophil platelet...
Abstract Mammalian J-domain protein DNAJC9 interacts with histones H3–H4 and is important for cell proliferation. However, its exact function remains unclear. Here, we show that, in the fission yeast Schizosaccharomyces pombe, loss of Djc9, ortholog DNAJC9, renders histone chaperone Asf1 no longer essential growth. Utilizing AlphaFold-based structural prediction, identified a histone-binding surface on Djc9 that binds to helix α3 H3 manner precludes simultaneous α3-binding by Asf1. indeed...
Retrospective cohort study. To investigate the clinical and radiologic outcomes of unilateral biportal endoscopic lumbar interbody fusion (ULIF) for single-segment spinal stenosis with instability. Unilateral technology has developed rapidly, ULIF is a new type minimally invasive surgery. However, there remains lack sufficient evidence regarding its efficacy. By comparing it posterior (PLIF) surgery, efficacy can be evaluated. In total, 110 (ULIF group, 54; PLIF 56) patients were included....
Abstract A single oral exposure to the trichothecene vomitoxin (VT) has been previously shown in mouse increase splenic mRNA levels for several cytokines as little 2 h. Since one underlying mechanism these effects likely involves superinduction of transiently expressed cytokine genes, VT may also potentially amplify responses inflammatory stimuli. To test this possibility, on tumor necrosis factor- (TNF- ), interleukin-6 (IL-6), and IL-1 expression were measured mice that intraperitoneally...
Human exposure to Gram-negative bacterial lipopolysaccharide (LPS) is common and may have an important influence on chemical toxicity. LPS has been shown previously enhance synergistically the toxicity of trichothecene mycotoxins. Because either these toxin groups alone characteristically target lymphoid organs at high doses, we evaluated effects coexposure subthreshold doses Salmonella typhimurium vomitoxin (VT) administered by intraperitoneal injection oral gavage B6C3F1 mice,...
Background/Aims: The study aims to elucidate the roles of 1,25(OH)2D3 and vitamin D receptor (VDR) in pathogenesis rheumatoid arthritis (RA) systemic lupus erythematosus (SLE) by regulating activation CD4+ T cells PKCδ/ERK signaling pathway. Methods: From January 2013 December 2015, a total 130 SLE patients, 137 RA patients healthy controls were selected this study. Serum levels VDR mRNA expression detected ELISA real-time fluorescence quantitative PCR (RT-qPCR). Density gradient...
Significance The regulation of ubiquitylation is critical to maintain proteomic and cellular homeostasis. cullin-RING E3 ubiquitin ligases (CRLs) mediate one-fifth all ubiquitylation, but their largely unknown. Here, we describe how the generation a small metabolite, inositol hexakisphosphate (IP6), locally switches two CRLs from active inactive state by means stabilizing interaction with an inhibitor: constitutive photomorphogenesis 9 signalosome. Furthermore, demonstrate physiologic...
The responses of immunological factors to different subtypes Kawasaki disease (KD) remain poorly understood. We recruited 388 patients with KD, 160 infectious febrile and 85 normal children who served as control subjects. Both the levels percentages T lymphocyte subsets, natural killer cells (NK cells) B were analyzed via flow cytometry. serum IgG, IgM, IgA C3, C4 assessed velocity scatter turbidimetry. most significant differences noted between elevated cells, C3 ratio CD4/CD8, decreased...
Bile salt export pump (BSEP) have been confirmed to play an important role for bile acid canalicular in the treatment of cholestasis. In this study, we investigated stimulatory effect emodin on BSEP signaling pathway cholestasis.Cell and animal experiments were given different concentrations emodin. The upstream molecule farnesoid X receptor was down-regulated by small interfering RNA (siRNA) technology or guggulsterones up-regulated lentivirus GW4064. Real-time PCR Western blotting employed...
The Cullin-RING ligases (CRLs) are the largest family of ubiquitin E3s activated by neddylation and regulated deneddylase COP9 signalosome (CSN). inositol polyphosphate metabolites promote formation CRL–CSN complexes, but with unclear mechanism action. Here, we provide structural genetic evidence supporting hexakisphosphate (IP 6 ) as a general CSN cofactor recruiting CRLs. We determined crystal structure IP in complex subunit 2 (CSN2), based on which identified -corresponding electron...
Encephalitis in hand, foot, and mouth disease (HFMD) is a serious threat to children's health life. Toll-like receptor 3 (TLR3) an innate immune-recognition that can recognize virus initiate immune responses. Emodin has the effects of anti-inflammatory regulating function, but mechanism not very clear.Cells mice were pretreated with coxsackievirus B3m (CVB3) treated emodin. The messenger ribonucleic acid (mRNA) protein levels TLR3 downstream molecules detected by quantitative real-time...
Killer meiotic drivers (KMDs) are selfish genetic elements that distort Mendelian inheritance by selectively killing products lacking the KMD element, thereby promoting their own propagation. Although KMDs have been found in diverse eukaryotes, only a limited number of them characterized at molecular level, and mechanisms remain largely unknown. In this study, we identify gene previously deemed essential for cell survival fission yeast