A5000934098- Renal Diseases and Glomerulopathies
- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Ion Transport and Channel Regulation
- Inflammasome and immune disorders
- Nephrotoxicity and Medicinal Plants
- Renal and related cancers
- Hormonal Regulation and Hypertension
- Gout, Hyperuricemia, Uric Acid
- Cell Adhesion Molecules Research
- Pediatric Urology and Nephrology Studies
- Chronic Kidney Disease and Diabetes
- Digestive system and related health
- Immunodeficiency and Autoimmune Disorders
- Angiogenesis and VEGF in Cancer
- Birth, Development, and Health
- Mesenchymal stem cell research
- Renal and Vascular Pathologies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer, Stress, Anesthesia, and Immune Response
- Blood groups and transfusion
- Dialysis and Renal Disease Management
- Hepatitis C virus research
- Pregnancy and Medication Impact
- Acute Kidney Injury Research
Central South University
2014-2024
Second Xiangya Hospital of Central South University
2012-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2022
Wenzhou Medical University
2022
Xiangya Hospital Central South University
2011-2021
First Affiliated Hospital of Xi'an Jiaotong University
2018
Changsha Medical University
1999-2000
To explore the approaches and diagnostic yield of genetic testing for renal disease in children, we describe genotype phenotype national cohort children with from 13 different regions China recruited 2014 to 2018 by building up multicenter registration system (Chinese Children Genetic Kidney Disease Database, CCGKDD). diagnosis was confirmed 42.1% our 1001 pediatric patients clinical suspicion a disease. Of 106 distinct monogenetic disorders detected, 15 accounted 60.7% diagnoses. The 29.1%...
Abstract Background Previously, several studies have indicated that pediatric IgA nephropathy (IgAN) might be different from adult IgAN, and treatment strategies also between IgAN IgAN. Methods We analyzed two prospective cohorts established by nephrologists, respectively. A comprehensive analysis was performed investigating the difference in clinical pathological characteristics, treatment, prognosis children adults with Results total of 1015 1911 were eligible for analysis. More frequent...
Background/Aims: The study aims to elucidate the roles of 1,25(OH)2D3 and vitamin D receptor (VDR) in pathogenesis rheumatoid arthritis (RA) systemic lupus erythematosus (SLE) by regulating activation CD4+ T cells PKCδ/ERK signaling pathway. Methods: From January 2013 December 2015, a total 130 SLE patients, 137 RA patients healthy controls were selected this study. Serum levels VDR mRNA expression detected ELISA real-time fluorescence quantitative PCR (RT-qPCR). Density gradient...
Systemic lupus erythematosus (SLE) is an autoimmune-mediated diffuse connective tissue disease characterized by immune inflammation with unclear aetiology and pathogenesis. This work profiled the intestinal flora faecal metabolome of patients SLE using 16S RNA sequencing gas chromatography-mass spectrometry (GC-MS). We identified unchanged alpha diversity partially altered beta flora. Another important finding was increase in Proteobacteria Enterobacteriales decrease Ruminococcaceae among...
Abstract Background IFN-induced protein 44-like ( IFI44L ) promoter methylation has been demonstrated to serve as an effective blood diagnostic biomarker for adult-onset SLE. However, its utility a marker childhood-onset SLE (cSLE) remains be verified. Methods Initially, we conducted differential analysis of gene and mRNA expression patterns in cSLE whole samples obtained from the public GEO database determine assess status at CpG sites. Subsequently, collected clinical 49 patients 12...
Abstract Background The incidence of AKI appears to have increasing trend. Up now, prospective, multi-center, large-sample epidemiological study done on pediatric aspects characteristics, causes and outcomes not reported. It is necessary develop in our country AKI. aim this was determine the clinical features, etiology, acute kidney injury (AKI) Chinese children. Method Paediatric patients (≤18 years old) admitted 27 hospitals (14 children’s 13 general hospitals) affiliated with Medical...
Recent studies have shown that intestinal microbes and metabolites are involved in the pathogenesis of many diseases. However, whether how they related to Henoch–Schönlein purpura (HSP) has yet be understood. This work is designed detect gut microbes, serum children with HSP, trying discover etiology HSP. A total 86 were recruited this study, namely, 58 HSP (HSP group) 28 healthy as control groups (CON group). 16S rDNA amplicon sequencing technology UPLC-QTOF/MS non-targeted metabolomics...
Abstract Dent disease is a rare X‐linked recessive inherited tubular disease. In this multicenter study, the clinical presentation and genetic background of Chinese children with are studied to improve cognition diagnostic ability pediatricians. prospective cohort, we described genotype phenotype national cohort composed 45 pediatric probands belonging families from 12 different regions China recruited 2014 2018 by building up registration system. The CLCN5 gene 32 affected revealed 28...
Abstract Background Congenital anomalies of the kidney and urinary tracts (CAKUT) are leading cause failure in children with phenotypic genotypic heterogeneity. Our objective was to describe genetic spectrum identify risk factors for CAKUT. Methods Clinical data were derived from a multicenter network (Chinese Children Genetic Kidney Disease Database, CCGKDD) Chigene database. A total 925 CAKUT who underwent testing 2014 2020 across China studied. Data 584 wereobtained CCGKDD, including...
Background: System lupus erythematosus (SLE) is a severe multisystem autoimmune disease.Objective: To describe the clinical and pathological features, treatment, renal outcome in children under 18 years with nephritis (LN).Methods: The study was undertaken by questionnaire completed 26 Grade 3A hospitals' paediatric units China. comprised 788 (619 girls, 169 boys) diagnosed SLE American College of Rheumatology criteria (1997) during 2005–2010. Results biopsies were classified according to...
Although the original purpose of systemic lupus erythematosus (SLE) classification criteria was to distinguish SLE from other mimic diseases, and facilitate sample selection in scientific research, they have become widely used as diagnostic clinical situations. It is not known yet if regarding criteria, what problems might be encountered? This first study comparing three sets for SLE, 1997 American College Rheumatology (ACR’97), 2012 Systemic Lupus International Collaborating Clinics...
Abstract Background Schimke immuno-osseous dysplasia (SIOD) is a rare autosomal recessive disorder characterized by spondyloepiphyseal dysplasia, progressive renal insufficiency and defective cellular immunity. Podocytic infolding glomerulopathy (PIG) newly proposed disease entity microspheres or microtubular structures associated with podocytes into the glomerular basement membrane (GBM) on electron microscopy (EM). Case presentation A 4-year-old boy was admitted to our ward due proteinuria...
Systemic lupus erythematosus (SLE) is an autoimmune disease with multi-system involvement as the main manifestation, and has complex diverse clinical features. Studies on large samples have revealed that SLE patients a significantly increased risk of thrombotic events, which are also one important causes morbidity mortality in patients. Antiphospholipid syndrome (APS) rare disorder characterized by recurrent arterial venous thrombosis, pregnancy-related complications, persistence...
Current first-line anti-proteinuric treatments do not produce a satisfactory therapeutic effect in considerable number of patients with nephrotic syndrome (NS). Interest adrenocorticotropic hormone (ACTH) for the treatment NS has recently been revived. The present study investigated efficacy and safety ACTH children frequent relapsing (FRNS), steroid-dependent (SDNS), steroid-resistant (SRNS).The group was comprised receiving treatment. Patients serum cortisol concentrations <85.3 nmol/L who...
Kidney disease is manifested in a wide variety of phenotypes, many which have an important hereditary component. To delineate the genotypic and phenotypic spectrum pediatric nephropathy, multicenter registration system being implemented based on Chinese Children Genetic Disease Database (CCGKDD). In this study, all patients with kidney urological diseases were recruited from 2014 to 2020. analysis was conducted using exome sequencing for families multiple affected individuals nephropathy or...
Abstract Background and objectives The underlying mechanism of IgA vasculitis (IgAV) with nephritis (IgAVN) remains unclear. Therefore, there are no accurate diagnostic methods. Lipid metabolism is related to many immune diseases, so this study set out explore the relationship lipids IgAV IgAVN. Methods Fifty-eighth patients 28 healthy controls were recruited, which divided into six separate pools investigate alterations serum according clinical characteristics: group (HCs) (IgAVs), IgAVN...
Rationale: Lupus erythematosus panniculitis (LEP) is a rare subset of lupus erythematosus. The incidence LEP in systemic (SLE) ranges from 2% to 5%. In the previous literature, most patients were women aged 20 60 years, while pediatric cases rare, all whom appeared on their own without SLE.A 10-year-old female child with severe SLE presented. Patient concerns: A girl was admitted our hospital for marasmus and fatigue other typical manifestations well before appearance skin lesions. only...
SUMMARY: Objective: To investigate the distribution of polymorphisms in PAX2 gene children with Henoch–Schonlein purpura and without nephritis (HSPN HSP, respectively), particular attention to relationship between development kidney pathology. Methods: Genomic DNA was extracted from peripheral leukocytes 39 HSPN patients, 23 HSP patients 100 normal children, three known single nucleotide (SNP), including 1410C>T, 1521A>C 1544C>T exon 8 9 were studied as candidate polymorphisms. The...
In this study, we report the case of a 12-year-old male with X-linked ichthyosis (XLI) in association glomerular sclerosis, and our investigation into deletion pattern STS gene flanking regions DNA samples family members. We observed no features typical renal osteodystrophy or rickets, exception short stature, three afffected Audiometry, visual acuity olfactory sensation were normal. By performing PCR analysis steroid sulfatase (STS) on patients, discovered complete that involved entire...
Aims: Stem cell transplantation for the treatment of kidney diseases is dependent on choice transplant pathway. We evaluated safety human umbilical cord mesenchymal stem cells through peripheral infusion and their distribution in a rat model renal interstitial fibrosis (RIF). Method: Cryopreserved were infused via tail vein injection into rats with unilateral ureteral obstruction Sham-operated. Blood, kidney, heart, liver, spleen lung collected at 14, 21, 28 days after infusion. Testing...