A5101872028- Lung Cancer Diagnosis and Treatment
- Natural product bioactivities and synthesis
- Esophageal Cancer Research and Treatment
- Neuroblastoma Research and Treatments
- DNA Repair Mechanisms
- Synthesis and biological activity
- Glioma Diagnosis and Treatment
- PARP inhibition in cancer therapy
- Diabetes Management and Education
- Glycosylation and Glycoproteins Research
- Genomics, phytochemicals, and oxidative stress
- Venous Thromboembolism Diagnosis and Management
- 14-3-3 protein interactions
- Quinazolinone synthesis and applications
- Cardiac Valve Diseases and Treatments
- Endometriosis Research and Treatment
- Herpesvirus Infections and Treatments
- Adipose Tissue and Metabolism
- Acute Myocardial Infarction Research
- X-ray Diffraction in Crystallography
- Phytochemistry and Biological Activities
- Diabetes Management and Research
- Acupuncture Treatment Research Studies
- Advanced Radiotherapy Techniques
- Biochemical effects in animals
Weifang People's Hospital
2018-2025
Nanjing Medical University
2025
Southwest Petroleum University
2012-2025
Nanjing Brain Hospital
2025
Shanxi Datong University
2022-2025
Kunming University of Science and Technology
2011-2024
China Three Gorges University
2018-2024
Sheng Jing Hospital
2024
China Medical University
2009-2024
Inner Mongolia Medical University
2019-2023
Glioblastoma multiforme is the most common aggressive adult primary tumour of central nervous system. Treatment includes surgery, radiotherapy and adjuvant temozolomide (TMZ) chemotherapy. TMZ an alkylating agent prodrug, delivering a methyl group to purine bases DNA (O6-guanine; N7-guanine N3-adenine). The cytotoxic lesion, O6-methylguanine (O6-MeG) can be removed by methylguanine methyltransferase (MGMT; direct repair) in tumours expressing this protein, or tolerated mismatch...
Glioblastoma multiforme is the most common aggressive adult primary tumour of central nervous system. Treatment includes surgery, radiotherapy and adjuvant temozolomide (TMZ) chemotherapy. TMZ an alkylating agent prodrug, delivering a methyl group to purine bases DNA (O6-guanine; N7-guanine N3-adenine). The cytotoxic lesion, O6-methylguanine (O6-MeG) can be removed by methylguanine methyltransferase (MGMT; direct repair) in tumours expressing this protein, or tolerated mismatch...
Acute aortic dissection (AAD) and pulmonary embolism (PE) are two critical potentially fatal causes of chest pain. The simultaneous occurrence these conditions is exceptionally rare; however, when they co-occur, the conflicting therapeutic strategies required significantly elevate mortality rates. While venoarterial extracorporeal membrane oxygenation (VA-ECMO) has been extensively reported as a life-saving intervention for high-risk embolism, its application in management AAD remains highly...
Varicella-zoster virus (VZV) central nervous system infection is typically observed in immunocompromised patients, and there a lack of studies involving large samples non-immunocompromised individuals. In this study, we retrospectively analyzed 108 patients diagnosed with VZV infection. This retrospective study was conducted the Department Neurology, Affiliated Nanjing Brain Hospital, Medical University, China. Metagenomic next-generation sequencing (mNGS) cerebrospinal fluid (CSF) revealed...
Background With the popularity of smart phones and development information technology, more patients are adopting diabetes APPs for self-management. However, at present, there few research reports on effect those coming from China. Objective The purpose this study was to evaluate effectiveness applicability an APP blood glucose control that is widely popular among Chinese with type 2 mellitus (T2DM). Methods This a 2-center, factorial design, equal proportional distribution, superiority...
Vascular endothelial growth factor receptor-2 (VEGFR-2) kinase inhibition is a well-established strategy to promptly tackle tumor by suppression of angiogenesis. We report herein series 5-anilinoquinazoline derivatives substituted 1,3-disubstituted urea. All the newly synthesized compounds described were evaluated for VEGFR-2 and antiproliferative activity against various cancer cells. The novel 1-aryl, 3-aryl-disubstituted urea quinazolines effective inhibitors with in vitro IC50 values...
Abstract Background Sirtuin 3 (Sirt3) is a key regulator of energy metabolism and oxidative stress. To investigate the role Sirt3 in contrast-induced acute kidney injury (CIAKI), we established model both vivo vitro to explore potential mechanisms. Methods In vivo, CIAKI models wild-type (WT) Sirt3-knockout (Sirt3-KO) mice. Blood urea nitrogen (BUN) serum creatinine (Scr) were detected by enzyme-linked immunosorbent assay, Glomerular Filtration Rate (GFR) clearance also investigated. We...
Encephalitis in hand, foot, and mouth disease (HFMD) is a serious threat to children's health life. Toll-like receptor 3 (TLR3) an innate immune-recognition that can recognize virus initiate immune responses. Emodin has the effects of anti-inflammatory regulating function, but mechanism not very clear.Cells mice were pretreated with coxsackievirus B3m (CVB3) treated emodin. The messenger ribonucleic acid (mRNA) protein levels TLR3 downstream molecules detected by quantitative real-time...
To investigate the health-related quality of life (HRQL) long-term survivors inoperable esophageal squamous cell carcinoma (ESCC) treated with definitive radiation therapy, real-world trends in use advanced techniques, and their impact on survival outcomes ESCC patients.
Arsenic is a naturally occurring metalloid element that found in soil, air and water. Environmental arsenic exists in both organic inorganic states. Organic arsenicals are generally considered non toxic, whereas inorganic forms toxic. The mostacutely toxic form arsine gas. Inorganic arsenic exists predominantly trivalent (As3+) pentavalent (As5+) forms, where compounds more than pentavalent ones. Human activities have also intensified accumulation theenvironment. Organs most susceptible to...
Sleep is crucial for proper functioning of the brain, whereas lack sleep very common in modern society and can cause memory impairment. Hence, it great significance to find effective methods intervene pathogenesis impairment.We designed this study explore mechanism underlying therapeutic effects electroacupuncture (EA) on deficits caused by deprivation (SD).In study, we first utilized modified multiple platform method (MMPM) establish a rat model SD, which was followed use Y-maze Morris...
Lipopolysaccharide (LPS) is an endotoxin that causes inflammation, and the content of LPS increases gradually during process aging. Whether response colon to stimulation will increase with age yet unknown.The study investigated effects on adult aging rats.43 healthy male SD rats were divided into 4 different groups: group LPS-stimulated at months, 22 months. Rats stimulated by intraperitoneal injection (1mg/kg) for 24 h. The morphological changes observed, intestinal inflammatory response,...
Abstract Purpose To investigate the interobserver variability (IOV) in target volume delineation of definitive radiotherapy for thoracic esophageal cancer (TEC) among centers China, and ultimately improve contouring consistency as much possible to lay foundation multi-center prospective studies. Methods Sixteen throughout China participated this study. In Phase 1, three suitable cases with upper, middle, lower TEC were chosen, participants asked contour a group gross tumor (GTV-T), nodal...
Advancement of novel anticancer drugs into clinical use is frequently halted by their lack solubility, reduced stability under physiological conditions, and non-specific uptake normal tissues, causing systemic toxicity. Their progress to in the clinic could be accelerated development new formulations employing suitable complementary drug delivery vehicles.A robust method for apoferritin (AFt)-encapsulation antitumour benzothiazoles has been developed enhanced activity against...
Stomach cancer is the fourth most common worldwide. Identification of novel molecular therapeutic targets and development treatments are critical. Against a panel gastric carcinoma cell lines, activity 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203) was investigated. Adopting RT-PCR, Western blot immunohistochemical techniques, we sought to determine pharmacodynamic (PD) markers sensitivity investigate arylhydrocarbon (AhR) receptor-mediated signal transduction activation by 5F...
Background Osteoarthritis (OA) is the most common form of human polyarthritis. Many genetic factors have been implicated in OA. It was reported that a polymorphism gene interleukin-6 (IL-6) associated with OA knee. The aim this study to determine whether functional IL-6 promoter -174G/C (rs1800795) polymorphisms confer susceptibility knee Methods A meta-analysis conducted on association between and Electronic search at PubMed, EMBASE, Weipu database, Wanfang database select studies....
A single nucleotide polymorphism (SNP) in the second intron of human TERT (hTERT), rs2736100, acts as a critical factor hTERT synthesis and activation. The rs2736100 SNP was found to be associated with susceptibility many cancers. Recently, inhibition telomerase marked telomere shortening were determined closely increasing severity atherosclerosis. association between presence atherosclerosis evaluated 84 patients 257 healthy controls using multivariate logistic regression analyses....
Near-tetraploidy is a rare cytogenetic abnormality in myelocytic malignancies children and its significance unknown. To investigate the pathologic characteristics of near-tetraploidy child with acute myelogenous leukemia (AML-M4), bone marrow smears were prepared for morphologic analysis. Bone samples collected at presentation flow cytometry, by short-term (24 h) unstimulated culture R-banding conventional assay. We have performed multifactorial analysis laboratory test results. In this...