A5100737302- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Peptidase Inhibition and Analysis
- RNA Interference and Gene Delivery
- Bone Tissue Engineering Materials
- Radiopharmaceutical Chemistry and Applications
- Chemical Synthesis and Analysis
- Drug Transport and Resistance Mechanisms
- Reproductive Biology and Fertility
- Epigenetics and DNA Methylation
- Natural product bioactivities and synthesis
- Cancer, Hypoxia, and Metabolism
- Neuropeptides and Animal Physiology
- Microwave-Assisted Synthesis and Applications
- Phytochemical Studies and Bioactivities
- Carbohydrate Chemistry and Synthesis
- Asymmetric Hydrogenation and Catalysis
- Synthesis and Biological Evaluation
- Angiogenesis and VEGF in Cancer
- Histone Deacetylase Inhibitors Research
- Electrospun Nanofibers in Biomedical Applications
- Ovarian function and disorders
- Curcumin's Biomedical Applications
- Synthesis and biological activity
- Neuroendocrine Tumor Research Advances
Nebraska Medical Center
2015-2025
University of Nebraska Medical Center
2015-2025
Nankai University
2025
Shanghai Institute of Materia Medica
2016-2024
Chinese Academy of Sciences
2016-2024
North University of China
2024
BD Biosciences (United States)
2023-2024
Northwestern Polytechnical University
2024
Zhongnan Hospital of Wuhan University
2022
Wuhan University
2014-2022
Ovarian tissue cryopreservation may be a potential method of preserving fertility in women who have experienced gonadotoxic treatments. To improve the efficiency existing cryopreservation, we developed practical and convenient vitrification named needle immersed (NIV), which required less concentrated minimum volume solution. Mouse ovaries human ovarian cortex fragments were vitrified using NIV method, slow-freezing or dropping method. Their morphology, ultrastructure viability analyzed...
Background: An intimidating challenge to transporting drugs into the brain parenchyma is presence of blood–brain barrier (BBB). Glucose an essential nutritional substance for function sustenance, which cannot be synthesized by brain. Its transport primarily depends on glucose transporters capillary endothelial cells. In this paper, brain-targeted properties glucose-modified liposomes using polyethylene glycols with different chain lengths as linkers were compared and evaluated establish...
New glycosyl derivative of cholesterol was synthesized as a material for preparing novel liposome to overcome the ineffective delivery normal drug formulations brain by targeting (glucose transporters) GLUTs on BBB. Coumarin-6 used fluorescent probe. The results have shown that cytotoxicity capillary endothelial cells (BCECs) glucose-mediated containing coumarin-6 less than conventional liposome. BBB model in vitro established coculturing BCECs and astrocytes (ACs) rat test transendothelial...
Abstract The gastrin-releasing peptide receptor (BB2r) is overexpressed in a variety of cancers including prostate cancer. As consequence, the development BB2r-targeted diagnostic/therapeutic radiopharmaceuticals has been widely explored. Both subcutaneous and orthotopic mouse models have extensively used agent development, but side-by-side studies examining how biological parameters (tumor perfusion efficacy, hypoxic burden microvasculature density) impact delivery not reported. Herein, we...
Gemcitabine is a potent anticancer drug approved for the treatment of pancreatic, non-small-cell lung, breast, and ovarian cancers. The major deficiencies current gemcitabine therapy, however, are its rapid metabolic inactivation narrow therapeutic window. Herein, we employed polyethylene glycol-b-distearoylphosphatidylethanolamine (PEG-DSPE)/tocopheryl glycol 1000 succinate (TPGS) mixed micelles as delivery system, to improve pharmacokinetic characteristics enhance antitumor efficacy. By...
As versatile drug delivery systems, polymeric micelles have demonstrated particular strength in solubilizing hydrophobic anticancer drugs while eliminating the use of toxic organic solvents and surfactants. However, true promise as carriers for cancer therapy resides their potential ability to preferentially elevate exposure tumor achieve enhanced efficacy, which still remains be fully exploited. Here, we review various micellar constructs that exhibit permeation retention effect tumor,...
Introduction and Aims: For a scaffold material to be considered effective efficient for tissue engineering, it should biocompatible bioinductive. Silk fiber is natural suitable fabrication; however, silk conductive lacks tissue-inductive properties. One proposed method make the inductive introduce plasmids or viruses encoding specific growth factor into scaffold. In this study, we constructed adenoviruses bone morphogenetic protein-7 (BMP-7) incorporated these scaffolds. The osteoinductive...
Proteins involved in iron homeostasis have been identified as biomarkers for lupus nephritis, a serious complication of systemic erythematosus (SLE). We tested the hypothesis that renal accumulation occurs and contributes to injury SLE. Renal non-heme levels were increased (New Zealand Black x New White) F1 (NZB/W) mouse model nephritis compared with healthy White (NZW) mice an age- strain-dependent manner. Biodistribution studies revealed transferrin-bound kidneys albuminuric NZB/W mice,...
Combination of the prodrug technique with an albumin nano drug-loaded system is a novel promising approach for cancer treatment. However, long-lasting and far-reaching challenge treatment cancers lies in how to construct nanometer drug delivery lead compounds their derivatives.In this study, we reported preparation injectable nanoparticles (NPs) high quantitative loading based on NabTM technology paclitaxel palmitate (PTX-PA).Our experimental study tissue distribution vivo demonstrated that...
Neurotensin receptor subtype 1 (NTSR1) is overexpressed in numerous cancers. Our laboratory exploring the utilization of covalent cysteine protease inhibitors (e.g., E-64) to increase tumor retention targeted radionuclide therapeutics (TRTs) through protein adduct formation. Using this approach, we reported [177Lu]Lu-NA-ET1, an NTSR1-targeted construct. In work, continue exploration [177Lu]Lu-NA-ET1 three different NTSR1-positive cancer models. [177Lu]Lu-3BP-227, a clinically investigated...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTN-(1-benzotriazol-1-ylalkyl)amides, versatile .alpha.-amidoalkylation reagents. 1. .alpha.-Amidoalkylation of CH acidsAlan R. Katritzky, Juliusz Pernak, Wei Qiang Fan, and Franciszek SaczewskiCite this: J. Org. Chem. 1991, 56, 14, 4439–4443Publication Date (Print):July 1, 1991Publication History Published online1 May 2002Published inissue 1 July 1991https://pubs.acs.org/doi/10.1021/jo00014a020https://doi.org/10.1021/jo00014a020research-articleACS...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTN-[1-(Benzotriazol-1-yl)alkyl]amides, versatile amidoalkylation reagents. 5. A general and convenient route to N-(.alpha.-alkoxyalkyl)amidesAlan R. Katritzky, Wei Qiang Fan, Michael Black, Juliusz PernakCite this: J. Org. Chem. 1992, 57, 2, 547–549Publication Date (Print):January 1, 1992Publication History Published online1 May 2002Published inissue 1 January...
Background Despite the promising anticancer efficacy observed in preclinical studies, paclitaxel and tanespimycin (17-AAG) combination therapy has yielded meager responses a phase I clinical trial. One serious problem associated with paclitaxel/17-AAG is employment of large quantities toxic organic surfactants solvents for drug solubilization. The goal this study was to evaluate micellar formulation concurrent delivery 17-AAG vivo. Methodology/Principal Findings Paclitaxel/17-AAG-loaded...
Sodium aescinate (SA) is often used for intravenous (IV) injection owing to its anti-inflammatory, anti-exudative, increasing venous tension, improving blood circulation and reducing swelling activities. However, the clinical application of SA limited by strong irritation, short half-life low bioavailability. To overcome these defects, we intended modify encapsualing it with liposomes . was mixed a proper amount phospholipid lyophilized prepare liposome sodium (SA-Lip-I). Its physical...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNovel Dimroth rearrangements of the benzotriazole system: 4-amino-1-(arylsulfonyl)benzotriazoles to 4-[(arylsulfonyl)amino]benzotriazolesAlan R. Katritzky, Fu Bao Ji, Wei Qiang Fan, John K. Gallos, V. Greenhill, Roy W. King, and Peter J. SteelCite this: Org. Chem. 1992, 57, 1, 190–195Publication Date (Print):January 1992Publication History Published online1 May 2002Published inissue 1 January...