A5084018016- Breast Cancer Treatment Studies
- Cancer Treatment and Pharmacology
- Advanced Breast Cancer Therapies
- Breast Lesions and Carcinomas
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer Risks and Factors
- HER2/EGFR in Cancer Research
- Cancer and Skin Lesions
- DNA Repair Mechanisms
- PARP inhibition in cancer therapy
- Molecular Biology Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Radiopharmaceutical Chemistry and Applications
- Fungal Biology and Applications
- Ubiquitin and proteasome pathways
- Estrogen and related hormone effects
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Effects of Radiation Exposure
- MRI in cancer diagnosis
- Metabolism, Diabetes, and Cancer
- Medical Imaging Techniques and Applications
Guangdong Provincial People's Hospital
2019-2024
Guangdong Academy of Medical Sciences
2019-2024
Southern Medical University
2023-2024
Shandong First Medical University
2009-2024
First Hospital of China Medical University
2024
China Medical University
2024
Shandong Provincial Hospital
2024
Harbin Electric Corporation (China)
2023
China North Industries Group Corporation (China)
2022-2023
UCLA Jonsson Comprehensive Cancer Center
2019-2022
Idiopathic granulomatous lobular matitis (IGLM) is a rare non-specific inflammatory disease of the breast. Although IGLM completely benign, it easily confused with cancer due to progressive breast lump firmly unilateral and discrete mass, nipple retraction sinus formation. Patients are usually associated inflammation overlying skin. This study aimed investigate clinical characteristics IGLM, treatment options prognosis. From January 2010 February 2015, 75 patients in our hospital were...
Abstract Previous studies have shown that the addition of carboplatin to neoadjuvant chemotherapy improved pathologic complete response (pCR) rate in patients suffering from triple‐negative breast cancer (TNBC) and who obtained a pCR could achieve prolonged event‐free survival (EFS) overall (OS). However, no assessed effects combination docetaxel without anthracycline with taxane‐based anthracycline‐based regimens. The NeoCART study was designed as multicenter, randomized controlled,...
Invasive lobular carcinoma (ILC) and invasive ductal (IDC) account for most breast cancers. However, the overall survival (OS) differences between ILC IDC remain controversial. This study aimed to compare nonmetastatic in terms of prognostic factors ILC.This retrospective cohort used data from Surveillance, Epidemiology End Results (SEER) Cancer Database (www.seer.cancer.gov). Women diagnosed with 2006 2016 were included. A propensity score matching (PSM) method was our analysis reduce...
Diabetes is directly related to the risk of breast cancer (BC) occurrence and worsened BC prognosis. Currently, there are no specific treatments for diabetes-associated BC. This paper aims understand fundamental mechanisms diabetes-induced progression develop personalized treatments. It reports a metabolic reprogramming strategy (MRS) that pharmaceutical induction glucose import glycolysis with metformin NF-κB inhibitor (NF-κBi) while blocking export excessive lactate via inhibiting...
Abstract Background Appropriate tracing methods for sentinel lymph node biopsy (SLNB) play a key role in accurate axillary staging. This prospective, non-inferiority, phase III RCT compared the feasibility and diagnostic performance of ultrasound-assisted carbon nanoparticle suspension (CNS) mapping with dual tracer-guided SLNB patients early breast cancer. Methods Eligible had primary cancer without nodal involvement (cN0), or clinically positive nodes (cN1) that were downstaged to cN0...
Previous studies revealed that patients with early-stage metaplastic breast cancer (MBC) underwent mastectomy more often than breast-conserving therapy (BCT) mainly due to the larger tumor size. This study was performed compare survival outcomes following BCT versus for MBC.Surveillance, Epidemiology, and End Results (SEER) database used identify women diagnosed MBC (T1-3N0-3M0) between 2001 2016, who were treated either or mastectomy. We assessed overall (OS) cancer-specific (BCSS) using...
The overall risk of developing a second primary cancer is increasing.The purpose this study was to analyze the survival patients with breast diagnosed after prior and identify factors death in population.Using SEER database, we identified 1,310 woman between 2010 2015 as cohort.Clinicopathological characteristics were compared using Student t-test chi-square test.Fine Gray's regression used evaluate effect treatments on death.After propensity score matching (PSM), 9,845 pairs or 2011...
Although dual blockade HER2-based neoadjuvant chemotherapy is associated with excellent outcomes for human epidermal growth factor receptor 2 (HER2)-positive breast cancer, pertuzumab not available to all patients due cost. The optimal HER2-positive cancer in the presence of a single HER2 unknown. This study aimed compare efficacy and safety epirubicin/cyclophosphamide followed by docetaxel/trastuzumab (EC-TH) docetaxel/carboplatin/trastuzumab (TCH) setting under blockade.Patients stage...
Antiangiogenic therapy combined with chemotherapy could improve pathological complete response (pCR) for breast cancer. Apatinib is an oral tyrosine kinase inhibitor that selectively inhibits vascular endothelial growth factor receptor 2. We assessed the efficacy and safety of apatinib standard neoadjuvant in patients triple-negative cancer (TNBC).This single-arm, phase II study enrolled aged 18-70 years previously untreated stage IIA-IIIB TNBC. Patients received at a dose 250 mg once daily...
The abnormal PI3K/AKT/mTOR pathway is one of the most common genomic abnormalities in breast cancers including triple-negative cancer (TNBC), and pharmacologic inhibition these aberrations has shown activity TNBC patients. Here, we designed identified a small-molecule Comp34 that suppresses both AKT mTOR protein expression exhibits robust cytotoxicity towards cells but not nontumorigenic normal epithelial cells. Mechanically, long noncoding RNA (lncRNA) AL354740.1-204 (also named as...
Aberrant PP2Cδ inhibits p300-mediated p53 acetylation and activation via the ATM/BRCA1 pathway, leading to cancer progression.
Background and aims: Male breast cancer is an uncommon disease. The benefit of adjuvant chemotherapy in the treatment male patients has not been determined. aim this study was to explore value men with stage I–III cancer, we hypothesized that some may safely skip chemotherapy. Methods: between 2010 2015 from Surveillance Epidemiology End Results database were included. Univariate multivariate Cox analyses used analyse factors associated survival. propensity score matching method adopted...
Breast cancer (BC) is a prevalent disease that harms women's health, and in-depth investigations of the pathogenesis, treatment, prevention BC are focus many research programs. Chidamide (CHI) histone deacetylase suppressor depresses functions, thereby influencing cell growth through an epigenetic mechanism. However, CHI effects upon largely unknown. Present aimed to confirm possibility using combined with chemotherapy drug doxorubicin (DOX) prevent chemotherapeutic resistance in vivo...
586 Background: Taxane- and anthracycline-based neoadjuvant regimens have become a standard treatment for triple-negative breast cancer (TNBC). Previous studies shown that adding carboplatin to chemotherapy significantly improved pCR rate in TNBC patients. The NeoCART study was designed compare the efficacy safety of docetaxel plus with TNBC. Methods: as multicenter, randomized controlled, open-label, phase 2 trial. patients enrolled were at least 18 years old previously untreated stage...
Immune response which involves distinct immune cells is associated with prognosis of breast cancer. Nonetheless, less study have determined the associations different types patient survival and treatment response. In this study, A total 1,502 estrogen receptor(ER)-negative cancers from public databases were used to infer proportions 22 subsets cells. Another 320 ER-negative cancer patients Guangdong Provincial People's Hospital also included divided into testing validation cohorts. CD8+ T...