A5043710220- Liver Disease Diagnosis and Treatment
- Animal Vocal Communication and Behavior
- Animal Behavior and Reproduction
- Amphibian and Reptile Biology
- Hearing, Cochlea, Tinnitus, Genetics
- HIV/AIDS Research and Interventions
- Food Security and Health in Diverse Populations
- HIV, Drug Use, Sexual Risk
- Nutritional Studies and Diet
- Hearing Loss and Rehabilitation
- Diet, Metabolism, and Disease
- Bat Biology and Ecology Studies
- Innovations in Medical Education
- Neural dynamics and brain function
- Alcohol Consumption and Health Effects
- Nursing Roles and Practices
- Adolescent Sexual and Reproductive Health
- Global Health Workforce Issues
- LGBTQ Health, Identity, and Policy
- Obesity, Physical Activity, Diet
- Healthcare professionals’ stress and burnout
- Noise Effects and Management
- Liver Disease and Transplantation
- Homelessness and Social Issues
- Multisensory perception and integration
Charles R. Drew University of Medicine and Science
2019-2025
Johns Hopkins Medicine
2018-2023
Johns Hopkins University
2018-2023
Bethel University
2022-2023
Creative Commons
2023
University of Maryland, Baltimore
2022-2023
University of Idaho
2023
University of Minnesota
2010-2022
Twin Cities Orthopedics
2010-2021
UCLA Jonsson Comprehensive Cancer Center
2020-2021
Abstract Noise exposure is one of the most common causes hearing loss and peripheral damage to auditory system. A growing literature suggests that system can compensate for through increased central neural activity. The current study sought investigate link between noise exposure, increases in gain, synaptic reorganization, function. All axons nerve project cochlear nucleus, making it a requisite nucleus sound detection. As first synapse system, well positioned respond plastically input. To...
This study compares pre-exposure prophylaxis (PrEP) use among men who have sex with (MSM) a recent history of incarceration across various factors known to contribute HIV transmission risk, including sexual identity, race/ethnicity, activity, history, injection drug use, and internalized homophobia. We analyzed baseline lifetime PrEP (yes or no) 170 male-identifying participants enrolled in randomized-controlled trial Los Angeles County between 2019 2022. Using logistic regression, we...
Micro opioid receptor agonists are clinically valuable as analgesics; however, their use is limited by high abuse liability. Kappa also produce antinociception, but they do not micro agonist-like abuse-related effects, suggesting that may enhance the antinociceptive effects and/or attenuate of agonists. To evaluate this hypothesis, present study examined interactions between agonist fentanyl and kappa U69,593 in three behavioral assays rhesus monkeys. In an assay schedule-controlled...
Non-alcoholic fatty liver disease (NAFLD) is spreading worldwide, with a racial/ethnic disparity. We examined the gender role in difference NAFLD US population. analyzed data for 3,292 individuals ≥18 years old from NHANES 2017-2018, representative sample of non-institutionalized adult population US. Exclusions were subjects elevated transferrin level, chronic hepatitis B or C, excessive alcohol use, prescription medications that might cause hepatic steatosis. was diagnosed by FibroScan®...
Abstract An important and necessary step in the analysis of any communication system involves quantitative descriptions how signals vary at multiple levels organization (e.g., species, populations, individuals). Such provide a basis for generating testable predictions about functions their specific physical properties different behavioral contexts. Here, we report results from acoustical statistical analyses advertisement calls boreal chorus frog, Pseudacris maculata . In addition to...
Plasticity of thalamocortical (TC) synapses is robust during early development and becomes limited in the adult brain. We previously reported that a short duration deafening strengthens TC primary visual cortex (V1) mice. Here, we demonstrate restores NMDA receptor (NMDAR)-dependent long-term potentiation (LTP) onto principal neurons V1 layer 4 (L4), which accompanied by an increase NMDAR function. In contrast, did not recover depression (LTD) at synapses. Potentiation absent...
Hepatic steatosis (HS) is a growing problem in adults worldwide, with racial/ethnic disparity the prevalence of disease. The purpose this study was to characterize stages (normal/mild [S0/S1], moderate [S2], and severe [S3]) HS Mexican Americans other Hispanics compared groups. We analyzed data for 5,492 individuals 12 years older from newly released National Health Nutrition Examination Survey 2017‐2018, which representative sample US adult population. diagnosed by FibroScan using...
We developed and tested Passport to Wellness (PtW), a client-centered intervention improve engagement in HIV/STI prevention services social determinants of health among Black men who have sex with (BMSM) using incentives peer support. assessed PtW's impact on screening pre/post-exposure prophylaxis (PrEP/PEP) knowledge/uptake randomized trial that compared the full one lacking changes within groups surveyed at baseline 6 months. enrolled 80 eligible BMSM, 399 screened. Among retained...
Environmental noise is a major source of selection on animal sensory and communication systems. The acoustic signals other animals represent particularly potent sources for chorusing insects, frogs, birds, which contend with multi-species analog the human "cocktail party problem" (i.e., our difficulty following speech in crowds). However, current knowledge diverse adaptations that function to solve problems nonhuman remains limited. Here, we show lung-to-ear sound transmission pathway frogs...
Aging leads to degeneration of the peripheral and central auditory systems, hearing loss, difficulty understanding sounds in noise. is also associated with changes susceptibility or recovery from damaging noise exposures, although effects interaction between acute exposure age on perception are not well studied. We tested these CBA/CaJ mouse model age-related loss using operant conditioning procedures before after longitudinally measured their sensitivity for detecting tones quiet...
Aim: Non-alcoholic fatty liver disease (NAFLD) exhibits a racial disparity. We examined the prevalence and association between race, gender, NAFLD among prediabetes diabetes populations adults in United States. Methods: analyzed data for 3,190 individuals ≥18 years old from National Health Nutrition Examination Survey (NHANES) 2017–2018. was diagnosed by FibroScan ® using controlled attenuation parameter (CAP) values: S0 (none) < 238, S1 (mild) = 238–259, S2 (moderate) 260–290, S3...
The abnormal PI3K/AKT/mTOR pathway is one of the most common genomic abnormalities in breast cancers including triple-negative cancer (TNBC), and pharmacologic inhibition these aberrations has shown activity TNBC patients. Here, we designed identified a small-molecule Comp34 that suppresses both AKT mTOR protein expression exhibits robust cytotoxicity towards cells but not nontumorigenic normal epithelial cells. Mechanically, long noncoding RNA (lncRNA) AL354740.1-204 (also named as...
Numerous and non-acoustic experimental factors can potentially influence outcomes in animal models when measuring the effects of noise exposures. Subject-related factors, including species, strain, age, sex, body weight, post-exposure measurement timepoints, observed hearing deficits. Experimenter effects, such as experience with techniques handling, may also factor into reported thresholds. In this study, subject mass, age at exposure, timepoint recording are from a large sample CBA/CaJ...
Confusing health messages and environmental changes intended to prevent the spread of COVID-19 virus have affected dietary behavior older African Americans. We investigated impact COVID-19-related factors on diet quality relationship between food access quality. surveyed 150 Americans aged 55 years above during pandemic. The data obtained included socio-demographic information, knowledge perceptions. Dietary intake was using Diet History Questionnaire III. Analyses bivariate multivariable...
Abstract Sensory systems function most efficiently when processing natural stimuli, such as vocalizations, and it is thought that this reflects evolutionary adaptation. Among the best-described examples of adaptation in auditory system are frequent matches between spectral tuning both peripheral central anurans (frogs toads) frequency spectra conspecific calls. Tuning to temporal properties calls less well established, has so far been documented only system. Using evoked potentials, we asked...