A5022681647- Immune Cell Function and Interaction
- Microbial Inactivation Methods
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Hydrogen's biological and therapeutic effects
- Extracellular vesicles in disease
- Lung Cancer Research Studies
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- CAR-T cell therapy research
- Renal cell carcinoma treatment
- Lung Cancer Diagnosis and Treatment
- Liver physiology and pathology
- Plasma Applications and Diagnostics
- Neuroblastoma Research and Treatments
- Medical Imaging and Pathology Studies
- Toxin Mechanisms and Immunotoxins
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
Fuda Cancer Hospital
2014-2025
Ruikang Affiliated Hospital of Guangxi Medical University
2023-2025
Guangxi Center for Disease Prevention and Control
2023-2025
Guangxi University of Chinese Medicine
2022-2025
Guangxi University
2023-2024
Jinan University
2013-2023
Huazhong University of Science and Technology
2018
Union Hospital
2018
First Affiliated Hospital of Jinan University
2017
Xiamen University
2008-2013
Abstract Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy. Due to their HLA-independent mode of action, allogeneic can be considered clinical application. To apply in adoptive immunotherapy, the methodology used obtain adequate cell numbers with optimal effector function vitro needs optimized, and safety efficacy also need proven. Therefore, we developed a novel formula improve expansion peripheral γδ from healthy donors. Then, humanized mouse model validate...
<h3>Background</h3> Cholangiocarcinoma (CCA) is a highly aggressive and fatal tumor. CCA occurs in the epithelial cells of bile ducts. Due to increasing incidences, accounts for 3% all gastrointestinal malignancies. In addition comprehensive treatments cancer, such as surgery, chemotherapy, radiotherapy, during past few years, cellular immunotherapy has played an increasingly important role. As result our research, we have discovered γδ T cell-based CCA. <h3>Case presentation</h3> A...
BACKGROUND. The anti–programmed cell death 1 (anti–PD-1) antibody pembrolizumab is clinically active against non–small lung cancer (NSCLC). In addition to T cells, human natural killer (NK) reported have the potential prolong survival of patients with advanced NSCLC, also express PD-1. This study aimed investigate safety and efficacy plus allogeneic NK cells in previously treated NSCLC.
Abstract Immunotherapy has limited efficacy against locally advanced pancreatic cancer (LAPC) due to the presence of an immunosuppressive microenvironment (ISM). Irreversible electroporation (IRE) can not only induce immunogenic cell death, but also alleviate immunosuppression. This study aimed investigate antitumor IRE plus allogeneic γδ T cells in LAPC patients. A total 62 patients who met eligibility criteria were enrolled this trial, then randomized into two groups (A: n = 30 and B: 32)....
The aim of this study was to retrospectively assess the effect comprehensive cryosurgery (ablation intrapancreatic and extrapancreatic tumors) plus immunotherapy in metastatic pancreatic cancer.We divided 106 patients (57 men, 49 women; median age, 65 years) into cryoimmunotherapy (31 patients), cryotherapy (36 (17 chemotherapy groups (22 patients). Pretreatment immune function tested who underwent immunotherapy. Overall survival (OS) after diagnosis cancer assessed a 4-year follow-up.Median...
Background/Aims: We evaluated the clinical effectiveness of irreversible electroporation (IRE) in combination with immunotherapy using allogenic natural killer cells (NK) for stage IV hepatocellular carcinoma (HCC). Methods: The study involved 40 patients HCC who were divided equally into two groups: 1) simple IRE; and 2) IRE plus NK (IRE-NK); we mainly assessed overall survival (OS). Results: effect IRE-NK treatment was synergistic, i.e., not only did it enhance immune function, also...
In this study, the clinical efficacy of cryosurgery combined with allogenic natural killer cell immunotherapy for advanced hepatocellular cancer was evaluated. From October 2015 to March 2017, we enrolled 61 patients who met enrollment criteria and divided them into two groups: 1) simple cryoablation group (Cryo group, n = 26); 2) cells (Cryo-NK 35), safety short-term effects were evaluated firstly, then median progression-free survival, response rate disease control assessed. All adverse...
This study aimed to investigate the safety and short-term efficacy of irreversible electroporation (IRE) combined with allogenic natural killer (NK) cell immunotherapy in treatment patients unresectable primary liver cancer. Between October 2015 December 2016, 40 were enrolled randomly allocated either IRE group (n = 22) or IRE–NK 18). All adverse events experienced by recorded; changes tumor biomarkers [AFP, CA 19-9, circulating cells (CTCs)], lymphocyte number function, quality life,...
In the present study, we aimed to compare clinical outcome of autogeneic and allogeneic natural killer (NK) cells immunotherapy for treatment recurrent breast cancer. Between July 2016 February 2017, 36 patients who met enrollment criteria were randomly assigned two groups: NK group (group I, n=18) II, n=18). The efficacy, quality life, immune function, circulating tumor cell (CTC) level, other related indicators evaluated. We found that has better efficacy than therapy. Moreover, therapy...
Advanced cancer treatment is a huge challenge and new ideas strategies are required. Hydrogen exerts antioxidant anti-inflammatory effects that may be exploited to control cancer, the occurrence progression of which closely related peroxidation inflammation. We conducted prospective follow-up study 82 patients with stage III IV treated hydrogen inhalation using "real world evidence" method. After 3-46 months follow-up, 12 died in IV. 4 weeks inhalation, reported significant improvements...
Chemotherapy, targeted therapy, and immunotherapy are used against advanced non-small cell lung cancer. A clinically efficacious method for relieving the adverse events associated of such therapies is lacking. Fifty-eight adult patients were enrolled in our trial to relieve pulmonary symptoms or drugs. Twenty who refused drug treatment assigned equally randomly a hydrogen (H2)-only group control group. According results tumor-gene mutations drug-sensitivity tests, 10, 18, 10 into...
In recent years, the increase of post-transplantation diabetes mellitus (PTDM) after renal transplantation encourages people to do a lot research on disease. This paper conducted bibliometric study PTDM related literature explore risk factors kidney transplantation, as well current status, hotspots and development trends research, so provide reference for researchers in fields. We searched Web Science Core Collection (WoSCC) database from January 1, 1990, August 20, 2023, used VOSviewer,...
Neuroinflammation and abnormal energy metabolism have been shown to significantly contribute the progression of Alzheimer's disease (AD). Adenylate kinase 5 (AK5), an enzyme predominantly expressed in brain regulates ATP metabolism, has unclear role neuroinflammation AD. The AD datasets were derived from GEO public database analyze expression levels AK5 normal samples assess relationship between clinical characteristics patients. Functional enrichment analysis was employed investigate...
BACKGROUND Irreversible electroporation (IRE) is a novel local tumor ablation approach with the potential to activate host’s immune system. However, this insufficient prevent cancer progression, and complementary approaches are required for effective immunotherapy. AIM To assess immunomodulatory effects mechanism of IRE combined anti-programmed cell death protein 1 (PD-1) treatment in subcutaneous pancreatic models. METHODS C57BL-6 tumor-bearing mice were randomly divided into four groups:...
This study investigates baicalin, a flavonoid from Scutellaria baicalensis, as multi-target therapeutic for type 2 diabetes mellitus (T2DM) through cellular experiments, network pharmacology, and molecular docking. Baicalin improves pancreatic β-cell viability, reduces reactive oxygen species (ROS), attenuates apoptosis/senescence in methylglyoxal (MGO)-induced models. Network pharmacology identifies key targets including HIF-1α, Bax, Bcl-2, Caspase-3, while docking confirms strong...
As a novel genetic biomarker, the potential role of SH3D21 in hepatocellular carcinoma remains unclear. Here, we decipher expression and function human carcinoma. The level clinical significance patients, relationship between features tumor microenvironment (TME) promoting progression were analyzed based on bulk samples obtained from Cancer Genome Atlas (TCGA) International Consortium (ICGC) databases. Single-cell sequencing Gene Expression Omnibus (GEO) database employed to verify...