A5101757453- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Pancreatitis Pathology and Treatment
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Lipid metabolism and disorders
- Cancer Immunotherapy and Biomarkers
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastric Cancer Management and Outcomes
- Inflammatory Biomarkers in Disease Prognosis
- Radiomics and Machine Learning in Medical Imaging
- Ocular Diseases and Behçet’s Syndrome
- Sexual Differentiation and Disorders
- Shoulder Injury and Treatment
- Technology and Human Factors in Education and Health
- Nutrition, Genetics, and Disease
- Cancer Genomics and Diagnostics
- Abdominal Surgery and Complications
- Nutrition and Health in Aging
- Neonatal Health and Biochemistry
- Retinal and Optic Conditions
- Biomarkers in Disease Mechanisms
Shanghai Chest Hospital
2011-2025
Shanghai Jiao Tong University
2006-2025
Qingdao University
2019-2024
Qingdao Municipal Hospital
2019-2024
Children's Hospital of Philadelphia
2024
University of Pennsylvania
2024
Hangzhou Cancer Hospital
2011
Zhejiang Chinese Medical University
2009-2010
Zhejiang University
2009-2010
117th Hospital of People's Liberation Army
2009
Abstract Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy. Due to their HLA-independent mode of action, allogeneic can be considered clinical application. To apply in adoptive immunotherapy, the methodology used obtain adequate cell numbers with optimal effector function vitro needs optimized, and safety efficacy also need proven. Therefore, we developed a novel formula improve expansion peripheral γδ from healthy donors. Then, humanized mouse model validate...
Unlike lung adenocarcinoma, patients with advanced squamous carcinoma exhibit a low proportion of driver gene positivity, fewer effective treatment strategies available. Chemoimmunotherapy has now become the standard first-line for individuals diagnosed carcinoma. Serum metabolomics holds significant potential application in predicting responses to chemoimmunotherapy and is capable identifying validating biomarkers. The aim our study was establish model that can predict prognosis cell...
Aim: To study the relation of NOTCH3 and its gene polymorphisms with chemotherapy response prognosis patients Non-small cell lung cancer (NSCLC). Methods: A total 594 advanced stage NSCLC (IIIA, IIIB IV) were enrolled. All received Platinum-based chemotherapy. The expression in tumors determined. In vitro, several lines over-expression vector small interfering RNA (siRNA) to role regulation cellular biological behaviors. Results: genotype allele frequencies at 605C>T 1735T>C not...
Lung cancer, specifically non-small cell lung cancer (NSCLC), is the leading cause of cancer-associated mortality in world. In previous years, almost no significant advancements have been made towards molecular characterization NSCLC, which highlights requirement for novel target genes. Hypoxia inducible factor-1α (HIF-1α) known to be essential tumorigenesis, as it regulates expression numerous factors that are involved angiogenesis, cellular proliferation and apoptosis. However, direct...
At present non-small cell lung cancer (NSCLC) is still the leading cause of death induced by cancer. The aim this study to investigate prognostic factors advanced NSCLC.
Stem-like cells in solid tumors are purported to contribute cancer development and poor treatment outcome. The abilities self-renew, differentiate, resist anticancer therapies hallmarks of these rare cells, steering them into lineage commitment may be one strategy curb or progression. Vitamin D is a prohormone that can alter cell growth differentiation induce the stem-like cells. In this study, octamer-binding transcription factor 4 (OCT4)-positive/Nanog homeobox (Nanog)- positive lung...
Objective: The objective of the study was to observe effects Salvia miltiorrhiza on intercellular adhesion molecule 1 (ICAM-1) protein expression in lungs rats with severe acute pancreatitis (SAP) or obstructive jaundice (OJ). Methods: A total 288 were used for SAP- and OJ-associated experiments. randomly divided into sham-operated, model control, treated group. According difference time points after operation, SAP each group subdivided 3-, 6-, 12-hour groups, whereas OJ 7-, 14-, 21-, 28-day...
Abstract Aim: To investigate the effect of baicalin and octreotide on expression levels P‐selectin protein in multiple organs rats with severe acute pancreatitis explore underlying mechanism. Methods: Rats were randomly divided into sham‐operated, model control, baicalin‐treated octreotide‐treated groups. At 3, 6 12 h after operation, mortality rates rats, contents plasma endotoxin as well serum NO ET‐1, pathological changes organs, each group observed. Results: treated groups significantly...
Objective . To investigate the therapeutic effects and mechanism of Salvia miltiorrhizae in treatment SAP OJ. Methods A total 288 rats were used for SAP- OJ-associated experiments. The randomly divided into sham-operated group, model control group treated group. mortality rates rats, contents endotoxin and<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msub><mml:mrow><mml:mtext>PLA</mml:mtext></mml:mrow><mml:mn>2</mml:mn></mml:msub></mml:mrow></mml:math>in blood,...
<sec> <title>BACKGROUND</title> Immunotherapy has significantly advanced lung cancer treatment, particularly in nonsquamous non–small cell (NSCLC), with overall response rates between 50% and 60%. However, about 30% of patients only achieve a stable disease state. Cryoablation shown potential to enhance immunotherapy by modifying the tumor’s immune microenvironment through release antigens factors. Addressing how boost these is critical. </sec> <title>OBJECTIVE</title> This study aims...
Background Immunotherapy has significantly advanced lung cancer treatment, particularly in nonsquamous non–small cell (NSCLC), with overall response rates between 50% and 60%. However, about 30% of patients only achieve a stable disease state. Cryoablation shown potential to enhance immunotherapy by modifying the tumor’s immune microenvironment through release antigens factors. Addressing how boost these is critical. Objective This study aims investigate efficacy safety immunochemotherapy...
There are some changes in the new 9th edition Tumor-Node-Metastases (TNM) staging system for lung cancer, including subdividing M1c into M1c1 and M1c2 stage. The aim of this study was to assess prognostic performance updated classification try provide real-world application data among advanced adenocarcinoma patients with bone metastases. Advanced stage metastases who receiving first-line first-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) T790M-guided...