A5101440896- Land Use and Ecosystem Services
- Remote Sensing and Land Use
- Epilepsy research and treatment
- Burkholderia infections and melioidosis
- Environmental and Agricultural Sciences
- Sexual function and dysfunction studies
- Environmental Changes in China
- Geomechanics and Mining Engineering
- Pharmacological Effects and Toxicity Studies
- Geoscience and Mining Technology
- Conservation, Biodiversity, and Resource Management
- Myasthenia Gravis and Thymoma
- EEG and Brain-Computer Interfaces
- Fungal Biology and Applications
- Cancer-related molecular mechanisms research
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- MicroRNA in disease regulation
- Thermochemical Biomass Conversion Processes
- Neuroscience and Neuropharmacology Research
- Mycorrhizal Fungi and Plant Interactions
- Asthma and respiratory diseases
- Higher Education and Teaching Methods
- Genetic and phenotypic traits in livestock
- Peripheral Neuropathies and Disorders
Sichuan University
2020-2025
Capital Medical University
2010-2025
Sun Yat-sen University
2010-2025
West China Hospital of Sichuan University
2020-2025
Sanya Central Hospital
2014-2024
Northwest University
2018-2024
Lanzhou Jiaotong University
2024
National Center for Chronic and Noncommunicable Disease Control and Prevention
2024
Science and Technology on Surface Physics and Chemistry Laboratory
2019-2024
Jiangsu University
2023-2024
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) is well known as a major source for superoxide radical generation in leukocytes. Superoxide radicals play significant role brain ischemia–reperfusion (I/R) injury. Recent data have also shown expression of NOX the brain. However, manner by which involved pathologic processes after cerebral ischemia remains unknown. Therefore, we subjected mice deficient subunit, gp91 phox (gp91 -/-), those treated with inhibitor, apocynin, and...
Effectively identifying and managing the priority regulation areas (PRAs) of ecosystem services (ESs) are very important for improving supply–demand relationship (SDR) ESs promoting regional sustainable development. Based on InVEST model, geographic information system (GIS) spatial analysis statistical methods, this study assessed supply demand five types in Loess Plateau from 2000 to 2020, namely, water yield, food supply, carbon storage, soil conservation recreation. The quantitative...
It remains uncertain if the contralesional primary sensorimotor cortex (CL_PSMC) contributes to motor recovery after stroke. Here we investigated longitudinal changes in resting-state functional connectivity (rsFC) of CL_PSMC and their association with recovery. Thirteen patients who had experienced subcortical stroke underwent a series fMRI clinical assessments over period 1 year at 5 time points, i.e., within first week, 2 weeks, month, 3 months, onset. age- gender-matched healthy subjects...
// Hua Wei 1, * , Shi-Xing Gu 2, Yi-Dan Liang 3, Zhi-Jie 4 Hai Chen Mao-Guang Zhu Fang-Tian Xu 5 Ning He 6 Xiao-Juan 7 and Hong-Mian Li 1 Department of Endocrinology, The Affiliated Hospital Youjiang Medical University for Nationalities, Baise 533000, China 2 Burns & Plastic Surgery, 3 Central Laboratory Science, Fifth Guangxi First People's Nanning, Nanning 530022, Gland Orthopedics, Gannan University, Ganzhou 341000, Aesthetic Urinary These authors have contributed equally to this work...
Land surface elements, such as land use, are in constant change and dynamically balanced, driving changes global ecological processes forming the regional differentiation of landscapes, which causes many risks under multiple sources stress. The landscape pattern index can quickly identify disturbance caused by vulnerability ecosystem itself, thus providing an effective method to support spatial heterogeneity risk. A risk model based on degree interference fragility was constructed...
To overcome the compensatory effect between Topo I and II, one of reasons accounting for resistance SCLC patients, we are pioneering use 3-arylisoquinolines to develop dual inhibitors I/II management SCLC. A total 46 new compounds were synthesized. Compounds 3g (IC50 = 1.30 μM NCI-H446 cells 1.42 NCI-H1048 cells) 3x 1.32 2.45 selected detailed pharmacological investigation, due their outstanding cytotoxicity II inhibitory activity. effectively prevent cell proliferation, invasion, migration...
The transformation of tunica albuginea-derived fibroblasts (TAFs) into myofibroblasts plays an important role in the pathological progress Peyronie's disease (PD). However, no treatment which addresses this is currently available. Estrogen has been shown to inhibit progression fibrosis a number fibrotic diseases. aim study was determine whether estrogen [17β‑estradiol (E2)] suppresses diffentiation primary rat TAFs vitro. obtained from male Sprague‑Dawley rats were stimulated with either...
Erectile dysfunction (ED) is a major complication of diabetes, and many diabetic men with ED are refractory to common therapies. Adipose tissue-derived stem cells (ADSCs) have been shown improve erectile function in animal models. However, inadequate cell homing damaged sites has limited their efficacy. Therefore, we explored the effect ADSCs labeled superparamagnetic iron oxide nanoparticles (SPIONs) on improving streptozotocin-induced rats an external magnetic field. We found that SPIONs...
Abstract We aimed to investigate the exact effect of IL-17 on regulating neural stem cells (NSCs) stemness and adult neurogenesis in ischemic cortex after stroke, how Astragaloside IV(As-IV) regulated expression underlying mechanism. Photochemical brain ischemia model was established protein observed at different time stroke WT mice. At 3 days when peaked, knock out (KO) mice were used observe cell proliferation cortex. Then, As-IV administered intravenously assess apoptosis, proliferation,...
Abstract Therapeutic responses of non-small cell lung cancer (NSCLC) to epidermal growth factor receptor (EGFR) - tyrosine kinase inhibitors (TKIs) are known be associated with EGFR mutations. However, a proportion NSCLCs carrying mutations still progress on EGFR-TKI underlining the imperfect correlation. Structure-function-based approaches have recently been reported perform better in retrospectively predicting patient outcomes following treatment than exon-based method. Here, we develop...
Selection criteria for clinical trials medication-resistant epilepsy are used to limit variability and ensure safety. However, it has become more challenging recruit subjects trials. This study investigated the impact of each inclusion exclusion criterion on trial recruitment at a large academic center. We retrospectively identified all patients with focal or generalized onset who attended an outpatient clinic over consecutive 3-month period. assessed patient's eligibility commonly required...
To investigate the quantitative relationship between volume capture of rainfall and carbon emissions from bioretention facilities, this study introduces concept intensity rainfall. The influence four key factors—climatic conditions, aquifer height, permeability coefficient, facility area—was investigated using a residential neighborhood in Tianshui, China, as an example. results reveal that value is influenced not only by external environmental changes but also inherent attributes such area....