A5100427779- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Anesthesia and Neurotoxicity Research
- MicroRNA in disease regulation
- Neuroscience and Neuropharmacology Research
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Transcranial Magnetic Stimulation Studies
- Neural and Behavioral Psychology Studies
- Heart Rate Variability and Autonomic Control
- Intensive Care Unit Cognitive Disorders
- RNA Interference and Gene Delivery
- Neurological Disease Mechanisms and Treatments
- Stress Responses and Cortisol
- Hypothalamic control of reproductive hormones
- Nerve injury and regeneration
- Vagus Nerve Stimulation Research
- Neuroendocrine regulation and behavior
- RNA Research and Splicing
- Natural Compounds in Disease Treatment
- Tracheal and airway disorders
- 14-3-3 protein interactions
- Nicotinic Acetylcholine Receptors Study
- Cancer-related cognitive impairment studies
- Barrier Structure and Function Studies
Tianjin University of Traditional Chinese Medicine
2024-2025
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2024-2025
Nanjing University of Chinese Medicine
2024
Xi'an Medical University
2014-2023
Shanghai Sixth People's Hospital
2023
Shanghai Jiao Tong University
2023
Shanxi University of Traditional Chinese Medicine
2023
Fujian University of Traditional Chinese Medicine
2022-2023
Beijing Normal University
2022
Inner Mongolia Medical University
2022
The question of whether the human brain is an anatomical site persistent HIV-1 infection during suppressive antiretroviral therapy (ART) critical, but remains unanswered. presence virus in brains HIV patients whose viral load effectively suppressed would demonstrate not only potential for CNS to act as reservoir, also urgent need understand factors contributing behind blood-brain barrier. Here, we investigated first time cells harboring DNA and RNA from subjects with undetectable plasma...
Transcutaneous vagus nerve stimulation (tVNS) is an emerging non-invasive technique designed to stimulate branches of the distributed over body surface. Studies suggest a correlation between brain-gut-microbiota (BGM) axis and pathogenesis Alzheimer’s disease (AD). The BGM represents complex bidirectional communication system, with being crucial component. Therefore, electrical might have potential modify—most time probably in non-physiological way—the signal transmission within axis,...
Acute lung injury (ALI) is generally caused by severe respiratory infection and characterized overexuberant inflammatory responses inefficient pathogens-containing, the two major processes wherein alveolar macrophages (AMs) play a central role. Dysfunctional mitochondria have been linked with distorted hence disorders, but few treatments are currently available to correct these defects. Plant-derive nanovesicles gained significant attention because of their therapeutic potential, targeting...
Edaravone is clinically used for treatment of patients with acute cerebral infarction. However, the effect double application edaravone on neurogenesis in hippocampus following ischemia remains unknown. In present study, we explored whether pre- and posttreatment had any neural stem/progenitor cells (NSPCs) subgranular zone a rat model transient global elucidated potential mechanism its effects. Male Sprague-Dawley rats were divided into three groups: sham-operated ( n = 15), control...
Background:The transplantation of neural stem cells (NSCs) has been accepted as a promising therapeutic strategy for central nervous system disorders. However, the beneficial effect NSC upon functional recovery is limited due to unfavorable microenvironment (niche) at site trauma or degenerative disease in brain. Combination NSCs with neurotrophins may overcome hurdles impaired cell survival and neuronal differentiation.Material/Methods:In current study, neurotrophin-3 (NT-3) gene was...
MicroRNAs play crucial roles in tumorigenesis and tumor progression. miR-770 has been reported to be downregulated several cancers affects cancer cell proliferation, apoptosis, metastasis drug resistance. However, the role underlying molecular mechanism of human glioma remain unknown need further elucidated.The expression tissues lines was measured by quantitative real-time PCR (qRT-PCR) explore association with clinicopathological characteristics. The CDK8 detected qRT-PCR Western blotting...
Increasing studies have suggested that microRNAs (miRNAs) are involved in the development of gliomas. MicroRNA-216a has been reported to be a tumor-associated miRNA many types cancer, either as an oncogene or tumor suppressor. However, little is known about function miR-216a The present study was designed explore potential role We found significantly decreased glioma tissues and cell lines. Overexpression suppressed proliferation, migration, invasion cells. Leucine-rich repeat-containing G...
Major depression is a prevalent and long-lasting psychiatric illness with severe functional impairment high suicide rate. We have previously shown that the ventrolateral orbital cortex (VLO) plays key role in stress responses mice, but underlying mechanisms remains unclear. Here, we used proteomic method to identify differentially expressed proteins VLO of chronic unpredictable mild (CUMS) mice. Of 4,953 quantified proteins, 45 were following CUMS. The integrated pathway analyses identified...
Abstract Hippocampus has attracted the attention of neuroscientists for its involvement in a wide spectrum higher‐order brain functions and pathological conditions, especially persistent neurogenesis subgranular zone (SGZ). The development hippocampus was intensively investigated on animals such as rodents. However, prenatal human hippocampus, little information distribution neural stem/progenitor cells, newly generated neurons mature is available timetable series event even more obscure. So...
Background Anhedonia is a key symptom of major depressive disorder (MDD) and other psychiatric diseases. The neural basis anhedonia has been widely examined, yet the interindividual variability in neuroimaging biomarkers underlying individual-specific severity not well understood. Methods To establish an individualized prediction model anhedonia, we applied connectome-based predictive modeling (CPM) to whole-brain resting-state functional connectivity profiles MDD patients. Results CPM can...