A5036572434- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Microtubule and mitosis dynamics
- Histone Deacetylase Inhibitors Research
- Glioma Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Caveolin-1 and cellular processes
- Cancer Research and Treatments
- Cancer Mechanisms and Therapy
- 3D Printing in Biomedical Research
- Plant tissue culture and regeneration
- Mitochondrial Function and Pathology
- Polysaccharides and Plant Cell Walls
- Neuroscience and Neuropharmacology Research
- Mathematical Biology Tumor Growth
- Transgenic Plants and Applications
- Neuroscience and Neural Engineering
- Cancer, Lipids, and Metabolism
- Signaling Pathways in Disease
- Plant-based Medicinal Research
- Endoplasmic Reticulum Stress and Disease
- Cell Image Analysis Techniques
Shanghai Jiao Tong University
2018-2024
Shanghai First People's Hospital
2020-2021
Second Military Medical University
2014-2020
Chinese People's Liberation Army
2020
People's Liberation Army 401 Hospital
2020
General Hospital of Jinan Military Command
2016-2018
Shanghai Changzheng Hospital
2014-2015
Prolyl-4-hydroxylase subunit 2 (P4HA2) is a member of collagen modification enzymes involved in the remodeling extracellular matrix (ECM). Mounting evidence has suggested that deregulation P4HA2 common cancer. However, role glioma remains unknown. The present study aimed to elucidate expression pattern, oncogenic functions, and molecular mechanisms glioblastoma cells. TCGA datasets paraffin samples were used for examining expressions P4HA2. P4HA2-specific lentivirus was generated assess its...
Gliomas are the most common form of primary brain tumor in adult central nervous system. Altered expression and prognostic value transmembrane protein 97 (TMEM97) has been recently reported different types human tumors. However, association TMEM97and glioma is poorly defined. Here, we that TMEM97 was significantly increased tissues compared to non-tumorous tissues. Furthermore, levels were progressively with increasing histologic grade glioma. Higher level correlated shorter survival time...
Ubiquitin‐specific protease 22 ( USP 22) is a member of the “death‐from‐cancer” signature, which plays key role in cancer progression. Previous evidence has shown that overexpressed and correlates with poor prognosis glioma. The effect mechanism glioma malignancy, especially stemness, remain elusive. Herein, we find more enriched stem‐like tumorspheres than differentiated cells. knockdown inhibits stemness cell lines. With cell‐penetrating TAT ‐tag protein, B cell‐specific Moloney murine...
F‐box and WD repeat domain‐containing 7 ( FBW 7) is a SCF ‐type E3 ubiquitin ligase targeting multitude of oncoproteins for degradation. Acting as one the most important tumor suppressors, it frequently inactivated in various tumors. In this study we aimed to evaluate relationship with glioma pathology prognosis, examine its effect malignancies temozolomide TMZ )‐based therapy. Clinical tissues TCGA database analysis revealed that expression was correlated inversely histology positively...
Ubiquitin specific peptidase 44 (USP44) has been identified as an important component of spindle assemble checkpoint (SAC) to prevent the formation aneuploidy. However, recent study raised a controversy about effect USP44 in tumor. Here, we first confirmed intranuclear localization by testing several antibodies recognize endogenous USP44. Then, data from IHC and qRT-PCR assay indicated that high expression existed high-grade glioma tissues signified poor prognosis. Knockdown inhibited...
aims: None background: TMEM189 is a recently discovered transmembrane protein involved in ether glycerophospholipid synthesis and ferroptosis regulation. However, its role tumors are not well understood. objective: To elucidate the oncogenic effects prognostic values of tumors. method: We performed pan-cancer analysis using various databases, bioinformatics statistical tools, tissue microarray analysis. result: generally upregulated compared to normal tissues. High expression linked reduced...
Abstract Prolyl-4-hydroxylase subunit 2 (P4HA2), as a member of collagen modification enzymes, is induced under hypoxic conditions with essential roles in the maturation, deposition well remodeling extracellular matrix(ECM). Mounting evidence has suggested that deregulation P4HA2 common cancer. However, expression pattern and molecular mechanisms glioma remain unknown. Here, we demonstrate overexpressed inversely correlates patient survival. Knockdown inhibits proliferation, migration,...
Objective To investigate the expressions ofcyclin kinase subunit 1 (Cks1),S-phase associated protein 2 (Skp2) and Cyclin-dependent inhibitor p27 in human gliomas their correlations,and study possible role of Cks1 to glioma malignant progression.Methods Immunohistochemical staining (EnVision method) was used measure Cks 1,Skp2 34 samples 10 normal brain tissue slices,collected our hospital from June 2009 2011.Relationships between these levels proteins were analyzed.Results The...
Objective To observe the expression of ClC-3 and BK ion channels in rat glioma cells, speculate function invasion cells. Methods Conventional establishment C6 brain model Wistar rats, rats were randomly divided into 5 groups (glioma group, model+Chlorotoxin model+Iberiotoxin sham operation group control group). The immunohistochemical detection was performed. Furthermore, changes tumor volume after using CIC-3 specific inhibitor Chlorotoxin Iberiotoxin observed. Results ClC-3...