Relationship between ClC-3, BK type of ion channel and the invasive growth of glioma

• DOI: 10.3877/cma.j.issn.2095-123x.2018.01.009
• Publication Date: 2018-12-15
• Authors: Peigang Lu; Yuan Dong; Bo Li; Kuizhong Wang; Zhenqiang Hao; Guanzhong Qiu; Jingzheng Cao
• Keywords: Iberiotoxin; BK channel

Objective To observe the expression of ClC-3 and BK ion channels in rat glioma cells, speculate function invasion cells.

Methods Conventional establishment C6 brain model Wistar rats, rats were randomly divided into 5 groups (glioma group, model+Chlorotoxin model+Iberiotoxin sham operation group control group). The immunohistochemical detection was performed. Furthermore, changes tumor volume after using CIC-3 specific inhibitor Chlorotoxin Iberiotoxin observed.

Results ClC-3 channel highly expressed cell line, while relatively low; volum decreased significantly application (P<0.05), there no significant change Iberiotoxin.

Conclusion ClC-3 plays an important role invasive growth suggesting that might be a new target for treatment future.

Key words: Glioma; Invasion; ClC-3 channel; BK