A5102952470- Carbon and Quantum Dots Applications
- Electrochemical Analysis and Applications
- Advanced biosensing and bioanalysis techniques
- Nanocluster Synthesis and Applications
- Quantum Dots Synthesis And Properties
- Graphene and Nanomaterials Applications
- Perovskite Materials and Applications
- Luminescence and Fluorescent Materials
- Electrochemical sensors and biosensors
- Electrocatalysts for Energy Conversion
- Corrosion Behavior and Inhibition
- Analytical Chemistry and Sensors
- Advanced Nanomaterials in Catalysis
- Protein Degradation and Inhibitors
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Graphene research and applications
- 2D Materials and Applications
- Ubiquitin and proteasome pathways
- Concrete Corrosion and Durability
- Organic Light-Emitting Diodes Research
- Nanoparticle-Based Drug Delivery
- Epigenetics and DNA Methylation
- Catalytic Processes in Materials Science
- Advanced battery technologies research
Beijing Normal University
2012-2025
National Center for Nanoscience and Technology
2021-2024
Guangdong University of Technology
2012-2023
Shanxi Medical University
2022
Association for Women in Science
2018
Lanzhou University
2014
The synthesis, optical properties, and biomedical applications of CDs are summarized.
Large doses of anticancer drugs entering cancer cell nuclei are found to be effective at killing cells and increasing chemotherapeutic effectiveness. Here we report red-emissive carbon quantum dots, which can enter into the not only but also stem cells. After doxorubicin was loaded concentration 30 μg/mL on surfaces average viability HeLa decreased 21%, while it 50% for free doxorubicin. The doxorubicin-loaded dots exhibited a good therapeutic effect by eliminating This work provides...
Abstract Proteolysis targeting chimeras (PROTACs) technology is an emerging approach to degrade disease‐associated proteins. Here, we report carbon‐dot (CD)‐based PROTACs (CDTACs) that membrane proteins via the ubiquitin‐proteasome system. CDTACs can bind programmed cell death ligand 1 (PD‐L1), recruit cereblon (CRBN) induce PD‐L1 ubiquitination, and them with proteasomes. Fasting‐mimicking diet (FMD) also used enhance cellular uptake proteasome activity. More than 99 % or 90 of in CT26...
Abstract The development of bright and long‐lived aqueous room‐temperature phosphorescent (RTP) materials holds paramount importance in broadening the application scope RTP material system. However, conventional usually exhibit low efficiency short lifetime solution. Herein, an situ host–guest strategy is proposed to achieve cyanuric acid (CA)‐derived carbon nitrogen dots (CNDs) composite (CNDs@CA) that demonstrates a significant enhancement both quantum yield (QY) mediated by water....
The successful control of coronavirus disease 2019 (COVID-19) pandemic is not only relying on the development vaccines, but also depending storage, transportation, and administration vaccines. Ideally, nucleic acid vaccine should be directly delivered to proper immune cells or tissue (such as lymph nodes). However, current developed vaccines are normally treated through intramuscular injection, where do reside. Meanwhile, must stored in a frozen state that may hinder their application...
Abstract The transmembrane P-glycoprotein (P-gp) pumps that efflux drugs are a major mechanism of cancer drug resistance. They also important in protecting normal tissue cells from poisonous xenobiotics and endogenous metabolites. Here, we report fucoidan-decorated silica-carbon nano-onion (FSCNO) hybrid nanoparticle targets tumor vasculature to specifically release P-gp inhibitor anticancer into cells. targeting capability the is demonstrated using multiple models. Moreover, reveal superior...
Proteolysis-targeting chimera (PROTAC) has emerged as a promising strategy for degrading proteins of interest. Peptide-based PROTACs offer several advantages over small-molecule-based PROTACs, such high specificity, low toxicity, and large protein–protein interaction surfaces. However, peptide-based have intrinsic shortcomings that strongly limit their application including poor cell permeability stability potency. Herein, we designed nanosized hybrid PROTAC (GNCTACs) to target degrade human...
Abstract Carbon dots (CDs) have been extensively investigated as prime candidates for developing tumour theranostic platform due to their tunable fluorescence emission and excitation, good photostability, high water solubility biocompatibility. Herein, we will update the recent research latest development on preparation, hydrophilicity, biotoxicity optical property of CDs, well applications in multimodal bioimaging anticancer drug delivery. We mainly highlight vivo imaging tumour‐targeted...
Uncontrolled growth of tumor cells is highly dependent on the energy metabolism. Fasting-mimicking diet (FMD) a low-calorie, low-protein, low-sugar representing promising strategy for cancer treatment. However, triglyceride stored in adipose tissue hydrolyzed into free fatty acids and glycerol supply during FMD Herein, we design nutrient-sensing nanodrug, VFETX, which self-assembled with vitamin B1 (VB1), ferrous ions, etomoxir (ETX). treatment upregulate expression VB1 transporters cells,...
Effective antitumor nanomedicines maximize therapeutic efficacy by prolonging drug circulation time and transporting drugs to target sites. Although numerous nanocarriers have been developed for accurate tumor targeting, their limited water solubility makes stable storage challenging, poses biosafety risks in clinical translation. Herein, we choose reduced glutathione (GSH) quick synthesize gram-scale water-soluble large amino acids mimicking carbon quantum dots (LAAM GSH-CQDs) enriched...
A graphene oxide–Fe<sub>3</sub>O<sub>4</sub> nanocomposite against drug-resistant tumors by the combination of dual-drug chemotherapy and photothermal therapy with NIR.
The continual growth of tumor cells requires considerable nutrient consumption. Methotrexate (MTX) is used to treat certain types cancer by blocking the DNA and RNA productions through interfering one-carbon metabolism de novo purine pyrimidine synthesis. However, treatment MTX may cause many serious adverse effects, which hamper its clinical application. Herein, authors synthesize ferrous ions, histidine, assembled nanoparticles (FHM) deliver at site enhance sensitivity with histidine...
Abstract Proteolysis targeting chimeras (PROTACs) technology is an emerging approach to degrade disease‐associated proteins. Here, we report carbon‐dot (CD)‐based PROTACs (CDTACs) that membrane proteins via the ubiquitin‐proteasome system. CDTACs can bind programmed cell death ligand 1 (PD‐L1), recruit cereblon (CRBN) induce PD‐L1 ubiquitination, and them with proteasomes. Fasting‐mimicking diet (FMD) also used enhance cellular uptake proteasome activity. More than 99 % or 90 of in CT26...
Autophagy is one of the key pathways for tumor cell survival and proliferation. Therefore, inhibition autophagy has been extensively studied cancer therapy. However, current inhibitors lack specificity are ineffective in limiting progression. Herein, we report a nanoplatform tumor-site-targeted delivery hydroxychloroquine (HCQ) using insulin-like growth factors 2 receptor (IGF2R)-targeted liposomes (iLipo-H). A fasting-mimicking diet (FMD) used to increase levels cells, thereby increasing...