A5010625479- Metabolomics and Mass Spectrometry Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced MRI Techniques and Applications
- Cardiac Arrest and Resuscitation
- Advanced NMR Techniques and Applications
- Sepsis Diagnosis and Treatment
- Lanthanide and Transition Metal Complexes
- Metabolism and Genetic Disorders
- Mitochondrial Function and Pathology
- NMR spectroscopy and applications
- Traumatic Brain Injury Research
- Diet and metabolism studies
- Functional Brain Connectivity Studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- High Altitude and Hypoxia
- Magnetism in coordination complexes
- Cell Image Analysis Techniques
University of California, Los Angeles
2006-2024
Abstract Carbohydrate fuel augmentation following traumatic brain injury may be a viable treatment to improve recovery when cerebral oxidative metabolism of glucose is depressed. We performed primed constant sodium L‐lactate infusion in 11 moderate severely injured adults. Blood was collected before and periodically during the study. quantified global uptake lactate other systemic metabolites associated with energy metabolism. Our hypothesis that uptake, as measured by arteriovenous...
Abstract A new method for enhancing MRI contrast between gray matter (GM) and white (WM) in epilepsy surgery patients with symptomatic lesions is presented. This uses the radiation damping feedback interaction high‐field to amplify due small differences resonance frequency GM WM corresponding variations tissue susceptibility. High‐resolution damping‐enhanced (RD) images of vitro brain from five were acquired at 14 T compared conventional 1 ‐, proton density (PD)‐weighted images. The RD...
Treatment of severe traumatic brain injury (TBI) in the intensive care unit focuses on controlling intracranial pressure, ensuring sufficient cerebral perfusion, and monitoring for secondary injuries. However, there are limited prognostic tools no biomarkers or tests evolving neuropathology. Metabolomics has potential to be a powerful tool indirectly monitor dysfunctional metabolism. We compared metabolite levels simultaneously collected arterial jugular venous samples acute TBI patients...
Accurate pre-clinical study reporting requires validated processing tools to increase data reproducibility within and between laboratories. Segmentation of rodent brain from non-brain tissue is an important first step in preclinical imaging pipelines for which well are still under development. The current aims clarify the best approach automatic extraction studies immature rat. Skull stripping modules AFNI, PCNN-3D, RATS software packages were assessed their ability accurately segment by...
<title>Abstract</title> Objective Traumatic brain injury (TBI) is a life-threatening critical neurological in need of novel medical therapies. Metabolic dysfunction occurs after TBI and may be target for therapy. The objective was to explore the safety short term an infusion exogenous sodium lactate (ELI) as potential therapy enhance metabolism. Methods This non-randomized single arm, center observational study three-hour 16 patients with coma from severe TBI. Patients were consented...